Celiac disease

Medical Research Study to Test a Potential Celiac Disease Therapy Is Underway and Signing up Participants

There is no cure for celiac disease. But, there may soon be a new therapy to go along with a gluten-free diet.

A Phase II medical research study to test a potential therapy for people with celiac disease is underway and signing up participants at CeliacTrial.com.

celiac disease fasano

Alessio Fasano, MD. Co-founder of Alba Therapeutics

The investigational drug, Larazotide Acetate, was developed by Alba Therapeutics. It passed Phase I trials and is now being studied to determine how effective it is in different doses and whether side effects develop. Alba Therapeutics was co-founded by celiac disease researcher, Dr. Alessio Fasano, director of the Celiac Disease Center at the University of Maryland.1

The therapy is based on Dr. Fasano’s discovery that tight junctions between cells in the intestine can be opened or closed and that gluten relaxes these junctions. It is this process that leads to gluten improperly crossing into the body, thereby eliciting an immune reaction that leads to inflammation and damage characteristic of celiac disease.

“The reality is that the paracellular space is a gate, not a wall or fence. And if material gets through that space – even if it is only 1 to 5% of what normally travels through the cell – it could be associated with disease.”
-Alessio Fasano, MD1

Dr. Fasano discovered the potentially therapeutic utility of down-regulating intestinal permeability of celiac disease.1 In other words, he discovered that Read More »

MEDICAL RESEARCH: Vitamin D Deficiency is Associated with Insulin Resistance and ß cell Dysfunction

 

Editor’s note:

In the following medical research study, healthy participants were enrolled to examine the effects of vitamin D on insulin production and use in the body. This research shows that:

1) Vitamin D plays an important role in insulin sensitivity in the body, and deficiency of vitamin D hampers production of insulin hormone by beta cells in the pancreas.

2) People with vitamin D deficiency are at risk for developing type 2 diabetes mellitus. Type 2 diabetes mellitus is characterized by lack of insulin sensitivity in body tissues and inadequate production of insulin hormone in the pancreas. Read More »

MEDICAL RESEARCH: Vitamin D Necessary for Preserving Cognitive Function

 

Editor’s note: Promising research published January 8, 2007 shows that adequate levels of vitamin D in the elderly are important to maintain cognitive function or thinking skills that include use of language, awareness, social skills, math ability, memory, reasoning, judgment, intellect, learning, and imagination. This study is called a retrospective review because the researchers did not actually examine anyone. Instead they reviewed data from records of 32 older adults who had been examined for memory Read More »

MEDICAL RESEARCH: “Copper Deficiency in Infants with Active Celiac Disease.”

Editor’s note: In this case report of infants with severe malabsorption from celiac disease, the treating physicians found copper deficiencies based on blood studies that showed severe low copper levels and white blood cell count.  Treatment required copper supplementation in addition to the gluten-free diet.  Normally, in the last few months of gestation, an infant  stores a large amount of copper in their liver.  This storage must last about 6 months because infants must derive their nourishment from copper-poor milk.  This case report shows dramatically the terrible effect of malabsorption coupled with a naturally occurring huge demand for copper that could not be satisfied through digestion. Read More »

MEDICAL RESEARCH: “Pediatric case series evaluating a standardized Candida albicans skin test prod

 

 Editors’ note: This study investigating the value and safety of Candin for clinical use in children demonstrated effectiveness and safety.  Candin is a reagent or skin test for sensitivity to Candida albicans, a yeast microorganism that can cause infection.  The study recommends using Candin in combination with other reagents in infants with anergy to see if they react to antigens other than Candida albicans.  Anergy is described in Taber’s Cyclopedic Medical Dictionary as the impaired or absent ability to react to common antigens administered through skin testing. Antigens are markers on the surface of cells that stimulate production of antibodies.  In this study, Candin was tested at the same time as a skin test for tuberculosis (purified protein derivative tuberculosis) for comparison of results. Read More »

MEDICAL RESEARCH: “Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats.”

Editors’ note: This animal study investigating the effects of Lactobacillus rhamnosus, a strain of probiotic bacteria, on ulcers of the stomach lining of rats demonstrated that bacteria placed directly into the stomach significantly and according to dose reduced gastric ulcer size.  If the results of this animal research are reproduced in humans, it would demonstrate that probiotics may hasten recovery for people suffering from stomach ulcers.  The bacteria did not affect the function of normal gastric mucosa but normalized those with abnormal changes during ulceration. Read More »

Mental Health and Celiac Disease

If you’ve ever lived with undiagnosed Celiac Disease – chances are you’ve been to a psychologist at one time or another.  Perhaps your doctor told you that you had severe depression, bi-polar disorder, anxiety, or simply that it was “all in your head.” Believe me – I’ve been there, done that. I had even convinced myself as an undergrad in psychology, that with all the knowledge I was gaining, I would not only be able to fix my own problems, but that I’d some day be able to help everyone else fix their problems too. I would become so mentally tough that nothing could conquer me. The problem was -something was wrong … and it wasn’t really in my head. No amount of “positive thinking” could get me out of what I was going through. I didn’t want to be depressed – and yet I had depression. I didn’t want to feel anxiety, didn’t have any reason to be anxious – and yet, I had anxiety all the time. I knew who I was – but when I looked in the mirror, I wasn’t that person. Something else was going on- and it was beyond my control.

During my time as a psych student, I had begun to realize that what I was putting into my body had a direct effect on my mood, energy level, and overall happiness. I started paying close attention to what I was eating and how I would feel afterwards – which eventually led me to walk into my doctors office and ask for a blood test for Celiac Disease. When I finally got some answers – I thought, “Wow, no wonder I felt horrible at school all the time” because I would eat a Gordita or Mexican Pizza just about every day on the way to class at our campus Taco Bell. (Just for the record, Gluten + addicting Taco Bell cheese opiates = not a good combo ;) I began to truly understand that what I was putting into my body had a direct effect on my mind. (The GUT-BRAIN connection).  Read More »

Migraine Headaches and Celiac Disease

According to WebMD, approximately 45 million Americans suffer from chronic headaches, and of them, 28 million suffer from migraines.(1) A migraine headache is a neurologic disorder characterized by reduced cerebral blood flow. They are marked by periodic, usually one-sided pulsing headaches with or without aura and light and noise sensitivity or nausea.(1)

A 2003 medical study testing migraine sufferers for celiac disease showed that 4.4% had the disorder.(2) That would equate to more than 1.2 million migraine sufferers in the US having celiac disease.  Read More »

Miley Cyrus is Gluten-free, Casein-Free and The Latest Victim of Media Viciousness

John Libonati Gluten Free Works

Miley leaving her gym after a workout.

Miley Cyrus, the ultra popular nineteen year old singer and actress is the latest celebrity to fall victim to the media for being too healthy and too in-shape. And it’s all because she is gluten-free and casein-free.  Actually, the real reason is because many media “reporters” are vicious and misinformed. Their lack of concern for the truth and focus on sensationalism damages people like Cyrus, the gluten-free community and our society as a whole.

Here’s what went down…

Photos were taken of Miley leaving a pilates studio and looking SUPER fit and healthy. The media began by raving about Miley’s figure – how in-shape, fit and toned she looks. It was all “Yay Miley! We love Miley!” This was a win-win for everyone. Miley is famous, so the story sold. People got to see someone they recognize who was succeeding and looking Read More »

Most People Do Not Realize How Sick They Really Are 

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We are told the gluten-free diet is the only treatment for celiac disease and gluten sensitivity. We follow the diet, but do not recover fully. Many times, because we feel better than before, we do not grasp that we can be so much healthier than we are.
 
There are a host of health issues that can and should be treated through diet, supplements and medications, reducing inflammation and correcting deficiencies. Hundreds in fact.
 
Many times, we are told our symptoms are just who we are. And we accept that, because we don’t know any better.
 
Even our doctors have no idea that their patients who suffer from fatigue, thinning hair, flaking fingernails, poor vision, constant irritability, forgetfulness, mottled skin and hundreds of problems that they believe are “normal” day-to-day conditions actually result from Read More »
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