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RLS from low iron in celiac disease responds to a gluten-free diet

Low iron levels have been associated with increased severity of restless leg syndrome. The following medical case report discusses four patients with low iron and restless leg syndrome who were tested positive for celiac disease and placed on a gluten free diet. All four had improvement on the gluten free diet.

“Celiac disease as a Possible Cause for Low Serum Ferritin in Patients with Restless Legs Syndrome.”

Manchanda S, Davies CR, Picchietti D.

University of Illinois at Urbana-Champaign, College of Medicine, 506 S. Mathews Avenue, Suite 190, Urbana, IL 61801, USA.

OBJECTIVE: To describe celiac disease as a possible cause for low serum ferritin in patients with restless legs syndrome (RLS). BACKGROUND: Low iron stores have been found to be a risk factor for RLS with serum ferritin levels less than 45-50ng/mL associated with increased severity of RLS. It has become routine clinical practice to test serum ferritin in the initial assessment of RLS. Celiac disease is a common genetic disorder that can cause iron deficiency.

METHODS: Consecutive case series of four patients with RLS and serum ferritin below 25ng/mL, who had positive screening tests for celiac disease. RESULTS: We report four patients who had serum ferritin <12ng/mL and positive screening tests for celiac disease. All had celiac disease confirmed by duodenal biopsy and response to a gluten-free diet. RLS symptoms improved in all four, with two able to discontinue RLS medication and two responding without medication.

CONCLUSIONS: In patients with RLS and low serum ferritin who do not have an obvious cause for iron deficiency, we suggest looking for celiac disease by simple, inexpensive serologic testing. Diagnosis and treatment of celiac disease is likely to improve the outcome for RLS, as well as identify individuals who are at risk for the significant long-term complications of celiac disease.

Source: Sleep Med. 2009 Jan 10. [Epub ahead of print]
url: http://www.ncbi.nlm.nih.gov/pubmed/19138881

Many medicated health disorders stem from nutrient deficiencies.

This video looks at three of the most common: insomnia, migraine, and hypertension.

Watch as we use the Gluten Free Works Treatment Guide to find out which deficiencies are behind each!

Click here to find out more about the Gluten Free Works Treatment Guide!

Zinc may not be one of the more glamorous nutrients, but it should be.

Zinc is absolutely crucial to life. That said, most people are zinc deficient.

They may be highly functioning, but they are not truly healthy.

If the body does not have what it needs, things break down.

One of the most important functions of zinc is its role in supporting the immune system. It helps the body kill viruses and bacteria.

Read these articles to learn about zinc and how to make sure you are getting enough.

Understanding and Treating Zinc Deficiency in Celiac Disease

The mineral zinc is classified as an essential nutrient due to the vital functions it performs in our bodies.  It is found in almost every cell of the body with highest concentrations in the liver, pancreas, kidney, bone, and muscle. High concentrations occur in the brain, middle ear, eye, prostate gland, sperm, skin, hair, and nails. This micronutrient is essential for the activity of approximately 100 enzymes. Enzymes promote biochemical reactions in the body. Read More »