Tag Archives: Research

Celiac Expert Answers – Could a Gluten-Free Diet Lead to Other Diseases? Video!

John Libonati Gluten Free Works

Weight loss, fad, miracle cure…there is an enormous amount of misinformation concerning the gluten-free diet in the news, on the internet and even in the medical community.

One of the worst ideas being perpetuated is that following a gluten-free diet can somehow be bad for you.

Dr. Stefano Guandalini, Founder and Medical Director of Columbia University’s Celiac Disease Center, answers the important question – Could following a gluten-free diet lead to other diseases?

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Olmesartan Blood Pressure Medicine Linked to Celiac Disease Type Villous Atrophy

Olmesartan Benicar Villous Atrophy Celiac DiseaseI just received an email from the Celiac Disease Research Center at Columbia University regarding a study showing a possible association between a blood pressure medication and villous atrophy. The blood pressure medication is called olmesartan and it is also known as Benicar, Benicar HCT, Azor, and Olmetec.

According to this article, the three-year study was conducted by the Mayo Clinic in Rochester, Minnesota and it included 22 patients who had symptoms of celiac disease, but antibody blood tests did not support that diagnosis. During this study patients improved with discontinuation of the drug, while a gluten-free diet had had no impact on their Read More »

Medical Research Study to Test a Potential Celiac Disease Therapy Is Underway and Signing up Participants

There is no cure for celiac disease. But, there may soon be a new therapy to go along with a gluten-free diet.

A Phase II medical research study to test a potential therapy for people with celiac disease is underway and signing up participants at CeliacTrial.com.

celiac disease fasano

Alessio Fasano, MD. Co-founder of Alba Therapeutics

The investigational drug, Larazotide Acetate, was developed by Alba Therapeutics. It passed Phase I trials and is now being studied to determine how effective it is in different doses and whether side effects develop. Alba Therapeutics was co-founded by celiac disease researcher, Dr. Alessio Fasano, director of the Celiac Disease Center at the University of Maryland.1

The therapy is based on Dr. Fasano’s discovery that tight junctions between cells in the intestine can be opened or closed and that gluten relaxes these junctions. It is this process that leads to gluten improperly crossing into the body, thereby eliciting an immune reaction that leads to inflammation and damage characteristic of celiac disease.

“The reality is that the paracellular space is a gate, not a wall or fence. And if material gets through that space – even if it is only 1 to 5% of what normally travels through the cell – it could be associated with disease.”
-Alessio Fasano, MD1

Dr. Fasano discovered the potentially therapeutic utility of down-regulating intestinal permeability of celiac disease.1 In other words, he discovered that Read More »

Family Members of Persons with Celiac Disease Wanted for Research Study (STUDY IS CLOSED)

Gluten Free Works Jennifer Harris

(Editor’s Note: This study is closed.)

I just learned of a new study being conducted by The National Foundation for Celiac Awareness (NFCA) and Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts to better understand the attitudes and beliefs of family members of persons with celiac disease.

More information on the study and how you can get involved follows: 

Celiac disease occurs in 10% of first-degree family members, such as a parent or sibling, and up to 20% of second-degree family members, such as an aunt, uncle or

Gluten Free Works Facebook Commenters Share What They Want to Tell Every Doctor

Kelly Clayton Gluten Free Works

Imagine having the power to speak your mind. While you may be thinking to yourself that you already do speak your mind, I am talking about the power to tell every doctor in the world one thing.  We asked our Facebook followers the following:

“If you could tell every doctor on the planet one thing, what would it be?”

After 19 comments, the top three things that would be said to every doctor in the world were: listen to their patients, trust what patients are saying and know more about food allergies.

Listening to your patients

Such a simple idea: listening. It is amazing that many doctors do not listen to their patients, or pretend to listen.  Patients spend much time listening and mulling over what their doctors say, so why can’t doctors return the favor? Facebook follower Jenn Rheaume said, Read More »

BioLineRx Announces Publication of Pre-clinical Results Demonstrating Efficacy of BL-7010, an Oral Treatment for Celiac Disease and Gluten Sensitivity

Kelly Clayton Gluten Free Works

Just last week BioLineRx, a biopharmaceutical development company announced successful pre-clinical testing of a potentially revolutionary treatment for celiac disease.  This new treatment may help celiac disease patients reduce their gluten toxins to create an overall healthy body for all celiac disease patients.

Jerusalem, Israel – February 21, 2012 – BioLineRx (NASDAQ: BLRX; TASE: BLRX), a biopharmaceutical development company, announced the publication of pre-clinical results demonstrating that BL-7010, an orally available treatment for celiac disease, reduces gluten toxicity (the negative effect of gluten on the patient’s body). The research was published in the February edition of Gastroenterology.

The findings indicate that BL-7010 (previously called P(HEMA-co-SS)) reduces digestion of wheat gluten, thereby decreasing its Read More »

I’m deficient, You’re deficient, We’re all deficient? (Part 2)

In  Part 1 of this article about nutrient deficiencies in the gluten-free population, I posed four critiques and questions that I promised to answer in today’s part 2. Without further ado, here we go…

Critique #1 questioned the small sample size of the research. I can’t do anything about that, and there’s not much to be said about it, so let’s move on.

Next, I think it’s easiest to address critique #3: How did nutrient deficiencies in the gluten-free population compare to Americans as a whole? To answer that question, I pulled data regarding nationwide averages from the USDA’s Community Nutrition Mapping Project. If I amend yesterday’s table that showed the percent of the gluten-free population who are deficient in given nutrients, and add to it a column for the national averages, this is what you find:

 

Nutrient GF Deficiency Nationwide Deficiency
fiber 74% 92%
calcium 82% 69%
thiamin 59% 19%
riboflavin 25% 11%
B6 35% 26%
folate 85% 40%
B12 29% 20%
iron 41% 11%

 

These numbers change the perspective a bit, I think. It’s not simply that the gluten-free population is nutrient deficient. When you compare us to the national averages, it gets slightly more complex. In some cases, such as folate, riboflavin, thiamin, and iron, we’re two or more times as deficient (as a group) than the nation. However, in other cases, such as B12, B6, and calcium, we still have greater rates Read More »

I’m deficient, You’re deficient, We’re all deficient? (Part 1)

I was recently reading a press release from Nature’s Path Organic about two of their new cereals. The press release made a familiar argument: the cereals “provide gluten avoiders with whole grains… unlike many gluten-free cereals which forfeit nutritional benefits…” The implication is that many gluten-free cereals (and other gluten-free processed foods, by extension) are more highly processed in order to improve taste and texture. But they do so by sacrificing nutritional quality.

There is some truth to this logic. Foods made from whole grains are inherently healthier than heavily processed foods, and I’ll use our good old enemy – wheat – to demonstrate. I compared whole grain wheat flour (less processed) with white, unenriched wheat flour (more processed) across a range of nutrient measures. Not surprisingly, the wheat underwent a profound loss in Read More »

National Jewish Health Expert Discusses Psychological Aspect of Living with Life Threatening Food Allergies

Gluten Free Works Author Jennifer Leeson

Mary Klinnert National Jewish Health

Mary Klinnert, PhD at National Jewish Health

I recently had the pleasure of meeting Mary Klinnert, PhD at National Jewish Health. Mary is an expert in child psychology and has numerous previous research studies on the effects of asthma on mental health.  She started her career mostly focusing on asthma, but in recent years, has turned much of her attention to the psychological aspects of living with life threatening food allergies.

While meeting with Mary, she briefed me on a study she is conducting on the psychological aspects of food allergies and how this study differs from the majority of previous studies that mostly focus on quality of life issues related to living with food allergies.  The hope of Mary and the rest of the team is to get to the root of what is happening to families that sometimes contributes to deeper Read More »

Why Oats Should Be Excluded from the Gluten-Free Diet

oats glutenThe suitability of oats as part of the gluten-free diet has been a source of controversy, with some groups pointing to research suggesting oats are safe and others pointing to other research demonstrating oats are dangerous to those with celiac disease. Close inspection of available medical research clearly shows that oats, even “gluten-free” oats, should not be included in the gluten-free diet at this time.

Until the early 1990’s, oats were excluded from the gluten-free diet, along with wheat, barley and rye. Then, a few pilot studies suggested oats may not cause the harm previously thought. The idea was proposed that people with celiac disease would find their diet more palatable, and would benefit nutritionally, if they were allowed to eat oats.

Heavy contamination of many oat products with wheat, rye, and particularly barley, was a concern. Companies began to produce so-called “gluten-free oats.” These oats were tested for the presence of wheat, barley and rye. They are vigorously marketed as “safe” for celiacs. However, studies show that even “uncontaminated oats” (oats not containing wheat, barley or rye) are toxic to an unknown number of people with celiac disease.

Early studies proclaimed oats to be safe, but they have since been judged faulty with poor validity. Nevertheless, they opened the floodgates to Read More »

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