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Toxic Trio Identified as the Basis of Celiac Disease

ScienceDaily (July 22, 2010) — Walter and Eliza Hall Institute scientists have identified the three protein fragments that make gluten — the main protein in wheat, rye and barley — toxic to people with coeliac disease.

Professor Bob Anderson from the Walter and Eliza Hall Institute in Melbourne, Australia, has identified the three protein fragments that make gluten -- the main protein in wheat, rye and barley -- toxic to people with celiac disease. (Credit: Czesia Markiewicz, Walter and Eliza Hall Institute)

Their discovery opens the way for a new generation of diagnostics, treatments, prevention strategies and food tests for the millions of people worldwide with coeliac disease.

When people with coeliac disease eat products containing gluten their body’s immune response is switched on and the lining of the small intestine is damaged, hampering their ability to absorb nutrients. The disease is currently treated by permanently removing gluten from the patient’s diet.

Dr Bob Anderson, head of the Walter and Eliza Hall Institute’s coeliac disease research laboratory, said it had been 60 years since gluten was discovered to be the environmental cause of coeliac disease.

“In the years since, the holy grail in coeliac disease research has been to identify the toxic peptide components of gluten; and that’s what we’ve done,” Dr Anderson said.

The research, done in collaboration with Dr Jason Tye-Din, Dr James Dromey, Dr Stuart Mannering, Dr Jessica Stewart and Dr Tim Beissbarth from the institute as well as Professor Jamie Rossjohn at Monash University and Professor Jim McCluskey at the University of Melbourne, is published in the journalScience Translational Medicine.

Dr. Bob Anderson & John Libonati at an NFCA-sponsored event April 30, 2009 in Philadelphia, USA where Dr. Anderson described his research and vaccine.

The study was started by Professor Anderson nine years ago and has involved researchers in Australia and the UK as well as more than 200 coeliac disease patients.

The patients, recruited through the Coeliac Society of Victoria and the Coeliac Clinic at John Radcliffe Hospital, UK, ate bread, rye muffins or boiled barley. Six days later, blood samples were taken to measure the strength of the patients’ immune responses to 2700 different gluten fragments. The responses identified 90 fragments as causing some level of immune reaction, but three gluten fragments (peptides) were revealed as being particularly toxic.

“These three components account for the majority of the immune response to gluten that is observed in people with coeliac disease,” Dr Anderson said. Read More »

University of Maryland Gets Record $45M Donation for Celiac Research

Holy donations!  Congratulations to Dr. Alessio Fasano and the Center for Celiac Research at the University of Maryland Medical Center on receiving a $45 million private donation from the family of a grateful patient. 

The donation marks the largest single gift ever given to the university system and will be used to expand the University of Maryland Center for Celiac Research and study other autoimmune disorders such as multiple sclerosis and Type 1 diabetes. Read More »

Which Medications Do You No Longer Need Since Going Gluten-free?

John Libonati Gluten Free Works

On December 13, I posted a question on the Glutenfreeworks Facebook page to ask people who had adopted a gluten-free diet if they no longer needed medications they had been taking. The response was incredible. Dozens of people described how they no longer needed drugs, some of which they had been taking for years or decades.

Here is my post and their responses…

“I gave a presentation to a group and mentioned a friend who had been on Zantac for 20 years. I went on to say that once she went gluten-free the acid reflux disappeared. A woman in the audience stood up and said the same thing happened to her – she had been on it since she was 10 (I’m guessing she was in her mid to late 30s.).

My question for you is what medication (of any kind) were you on, before you went gluten-free, that you no longer need to take and how long did it take before you did not need it anymore?”

    •  

      Ashley Nikki Garcia Prilosec & zantec. ! 

      December 13 at 5:25pm · 
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      Lauren Smith I also took OTC for heartburn on a near daily basis. No more! 

      December 13 at 5:27pm · 
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      Surely Masquelier McMaster I’ve taken Neurontin for 10 years..GF since Sept. and realized in Nov. that I don’ t need it!  Read More »
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