Research

Study Finds Gluten Causes Digestive Symptoms and Fatigue in People Without Celiac Disease

irritable bowel glutenIn the first double blind randomized placebo-controlled study of gluten and symptoms in people without celiac disease, researchers from Australia have confirmed that gluten is a trigger of digestive symptoms and fatigue. They concede that “non-celiac gluten intolerance” may exist.

 

The researchers challenged and re-challenged people with IBS in whom celiac disease had been excluded whose symptoms were controlled on a gluten-free diet. These individuals were randomized to gluten-free diet with daily supplements of muffins and bread with a standard amount of gluten added or not added. Both the patients and the Read More »

Researchers Seeking Adults with Celiac Disease

Adults that have been diagnosed with Celiac Disease are being sought to participate in a study to identify factors associated with the development of Celiac Disease.  The goal of the study is to find the genes that may predispose individuals to develop this autoimmune disease.  Adults eligible to participate in this study must have been diagnosed with Celiac Disease through a small intestinal biopsy. Spouses may also be eligible to participate.

Participants will be asked to provide a blood sample, complete a questionnaire, and provide medical records regarding their diagnosis. There is no cost to Read More »

MEDICAL RESEARCH: Vitamin D Deficiency is Associated with Insulin Resistance and ß cell Dysfunction

 

Editor’s note:

In the following medical research study, healthy participants were enrolled to examine the effects of vitamin D on insulin production and use in the body. This research shows that:

1) Vitamin D plays an important role in insulin sensitivity in the body, and deficiency of vitamin D hampers production of insulin hormone by beta cells in the pancreas.

2) People with vitamin D deficiency are at risk for developing type 2 diabetes mellitus. Type 2 diabetes mellitus is characterized by lack of insulin sensitivity in body tissues and inadequate production of insulin hormone in the pancreas. Read More »

Copper Malabsorption in Untreated Celiac Disease Common

 

Editor’s note:  

In this study, researchers investigating the absorption of copper in untreated patients who had damage to their duodenum found anemia in 3 out of 10 of these patients that was due to copper deficiency.  They gave all the study subjects a solution of copper to drink that was equal to a daily dose then tested their blood level.  Read More »

Gut Microflora Associated Characteristics in Children with Celiac Disease

Editor’s note: This important study demonstrated that short chain fatty acid (SCFA) levels in stool samples were abnormal in participating children with celiac disease, with and without treatment with gluten-free diet. SCFAs are healthy energy byproducts produced by microflora (beneficial organisms) in the colon during fermentation of undigested carbohydrates arriving from the small intestine. SCFAs nourish the colonocytes, cells that line the colon, to maintain normal function. They also help absorb salts and water from stool.  

“Gut Microflora Associated Characteristics in Children with Celiac Disease”

Tjellström B, et. al.

Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden.

Am J Gastroenterol. 2005 Dec;100(12):2784-8.

 

Background and aim: The aim of the study was to investigate the Read More »

MEDICAL RESEARCH: Vitamin D Necessary for Preserving Cognitive Function

 

Editor’s note: Promising research published January 8, 2007 shows that adequate levels of vitamin D in the elderly are important to maintain cognitive function or thinking skills that include use of language, awareness, social skills, math ability, memory, reasoning, judgment, intellect, learning, and imagination. This study is called a retrospective review because the researchers did not actually examine anyone. Instead they reviewed data from records of 32 older adults who had been examined for memory Read More »

MEDICAL RESEARCH: “Pediatric case series evaluating a standardized Candida albicans skin test prod

 

 Editors’ note: This study investigating the value and safety of Candin for clinical use in children demonstrated effectiveness and safety.  Candin is a reagent or skin test for sensitivity to Candida albicans, a yeast microorganism that can cause infection.  The study recommends using Candin in combination with other reagents in infants with anergy to see if they react to antigens other than Candida albicans.  Anergy is described in Taber’s Cyclopedic Medical Dictionary as the impaired or absent ability to react to common antigens administered through skin testing. Antigens are markers on the surface of cells that stimulate production of antibodies.  In this study, Candin was tested at the same time as a skin test for tuberculosis (purified protein derivative tuberculosis) for comparison of results. Read More »

Study reports those diagnosed with celiac disease have reduced subsequent healthcare costs

According to the National Digestive Diseases Information Clearing House, a study published in the December 2008 issue of the Journal of Insurance Medicine reports that researchers from Columbia University and CIGNA HealthCare found that diagnosis of celiac disease substantially reduces subsequent health care costs. 

The research group, led by Peter Green, M.D., a renowned authority in celiac disease from Columbia University,  looked at medical records for 10.2 million CIGNA managed care members.   Read More »

Scientists Uncover Further Steps Leading to Celiac Disease

 

 3 06 08

Contact: Sally Webster
s.webster@qmul.ac.uk
44-207-882-5404
Queen Mary, University of London

Scientists who last year identified a new genetic risk factor for coeliac disease, have, following continued research, discovered an additional seven gene regions implicated in causing the condition. The team, lead by David van Heel, Professor of Gastrointestinal Genetics at Barts and The London School of Medicine and Dentistry, have further demonstrated that of the nine coeliac gene regions now know, four of these are also predisposing factors for type 1 diabetes. Their research sheds light not only on the nature of coeliac disease, but on the common origins of both diseases. It is published online today (2 March 2008) in Nature Genetics. Read More »

Toxic Trio Identified as the Basis of Celiac Disease

ScienceDaily (July 22, 2010) — Walter and Eliza Hall Institute scientists have identified the three protein fragments that make gluten — the main protein in wheat, rye and barley — toxic to people with coeliac disease.

Professor Bob Anderson from the Walter and Eliza Hall Institute in Melbourne, Australia, has identified the three protein fragments that make gluten -- the main protein in wheat, rye and barley -- toxic to people with celiac disease. (Credit: Czesia Markiewicz, Walter and Eliza Hall Institute)

Their discovery opens the way for a new generation of diagnostics, treatments, prevention strategies and food tests for the millions of people worldwide with coeliac disease.

When people with coeliac disease eat products containing gluten their body’s immune response is switched on and the lining of the small intestine is damaged, hampering their ability to absorb nutrients. The disease is currently treated by permanently removing gluten from the patient’s diet.

Dr Bob Anderson, head of the Walter and Eliza Hall Institute’s coeliac disease research laboratory, said it had been 60 years since gluten was discovered to be the environmental cause of coeliac disease.

“In the years since, the holy grail in coeliac disease research has been to identify the toxic peptide components of gluten; and that’s what we’ve done,” Dr Anderson said.

The research, done in collaboration with Dr Jason Tye-Din, Dr James Dromey, Dr Stuart Mannering, Dr Jessica Stewart and Dr Tim Beissbarth from the institute as well as Professor Jamie Rossjohn at Monash University and Professor Jim McCluskey at the University of Melbourne, is published in the journalScience Translational Medicine.

Dr. Bob Anderson & John Libonati at an NFCA-sponsored event April 30, 2009 in Philadelphia, USA where Dr. Anderson described his research and vaccine.

The study was started by Professor Anderson nine years ago and has involved researchers in Australia and the UK as well as more than 200 coeliac disease patients.

The patients, recruited through the Coeliac Society of Victoria and the Coeliac Clinic at John Radcliffe Hospital, UK, ate bread, rye muffins or boiled barley. Six days later, blood samples were taken to measure the strength of the patients’ immune responses to 2700 different gluten fragments. The responses identified 90 fragments as causing some level of immune reaction, but three gluten fragments (peptides) were revealed as being particularly toxic.

“These three components account for the majority of the immune response to gluten that is observed in people with coeliac disease,” Dr Anderson said. Read More »

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