BODY ORGANS AFFECTED

What Are Extraintestinal Lymphomas? Extraintestinal lymphomas (non-Hodgkin’s) are malignancies that arise in peripheral lymphatic tissue outside the intestinal tract from B-cell and T-cell lymphocytes. Q: What is peripheral lymphatic tissue? A: Peripheral lymphatic tissue includes lymph vessels, lymph, lymph nodes, and ...

What Is Refractory Celiac Disease? Refractory celiac disease, formerly called refractory sprue, is a severe complication characterized by persistence of symptoms and intestinal inflammation despite gluten free diet after 12 months.1 Refractory celiac disease appears in two forms, ulcerative jejunitis (RCD ...

What Is B-Cell Non-Hodgkin’s Lymphoma? Bcell non-Hodgkin’s lymphoma is a malignant, monoclonal (arising from a single cell) proliferation of lymphocytes that is preceded by lymphadenopathy and characterized by varying, less predictable spread than Hodgkin’s disease. Lymphadenopathy is enlargement of lymph ...

What Is Pruritic Skin? Pruritic skin is a symptom of a primary disease that may involve only the skin or a systemic disorder with other features and is characterized by chronic itching. Q: What part of skin is affected by ...

What Is Pityriasis Rubra Pilaris? Pityriasis rubra pilaris (PRP) is a chronic generalized exfoliative dermatitis (sloughing skin) characterized by erythema (redness), scaling, dilated plugged hair follicles, and keratoderma (thickened skin) of the hands and feet that is often associated with ...

What Is Melanoma? Melanoma is a cutaneous malignancy with rapid invasion and metastasis to other parts of the body. Melanoma is characterized by growth from melanocytes appearing as a new mole or enlarging from an exisiting mole, changing shape, size ...

What Is Acquired Ichthyosis? Acquired ichthyosis is an uncommon, nonhereditary cutaneous disorder characterized by dry, rough skin with prominent symmetrical scaling that involves significant portions of the body. Most microscopic studies of acquired ichthyosis exhibit hyperkeratosis (thickened skin) with a ...

What Is Hangnail? Hangnail is a broken strip of epidermis (piece of skin) at root or lateral (side) edge of fingernail or toenail that causes sharp pain. A hangnail develops because the skin around the nail is unhealthy due to ...

What Is Follicular Hyperkeratosis? Follicular hyperkeratosis is an abnormal skin condition characterized by disordered overgrowth of the horny layer of the epidermis with horny plugs filling the openings of hair follicles. The plugs look like bumps in hair follicles. Follicular ...

What Is Erythema Nodosum? Erythema nodosum is an inflammatory disorder involving the deep dermis layer of skin and subcutaneous fat septa that underlies the skin. It is characterized by eruptions of recurrent or persistent multiple painful, red nodules under the skin that ...

What Is Erythema Elevatum Diutinum? Erythema elevatum diutinum is a rare leucocytoclastic vasculitis thought to be caused by an immune response that is characterized by inflammation, a rash, and scarring of small blood vessels of the skin. A characteristic poorly defined ...

What Is Edema? Edema is an abnormal swollen condition of the skin characterized by excess extracellular fluid volume, meaning there is an increase of the fluid that normally surrounds cells. Edema may be hardly noticeable or it can become extensive. ...

What Is Acquired Cutis Laxa? Acquired cutis laxa is an uncommon skin disorder characterized by abnormal reduction and degeneration of elastic fibers of the skin that can appear simply as thick, saggy skin with loose folds to severe involvement showing ...

What Is Cutaneous Vasculitis? Cutaneous vasculitis is a vascular disease of small blood vessels serving the skin that is characterized by segmental (spotty) inflammation of affected vessel walls resulting in their necrosis (destruction). Scarring is seen in the affected skin ...

What Are Rounded Nails With Curved Ends? Rounded, curved, dark and dry nails are a well known feature of vitamin B12 deficiency. Q: How does vitamin B12 deficiency cause the nails to grow this way? A: Vitamin B12 deficiency affects ...