What Is Acquired Ichthyosis?
Acquired ichthyosis is an uncommon, nonhereditary cutaneous disorder characterized by dry, rough skin with prominent symmetrical scaling that involves significant portions of the body.
Most microscopic studies of acquired ichthyosis exhibit hyperkeratosis (thickened skin) with a reduced or absent granular layer.1
Q: What is the granular layer of skin?
A: The granular layer is the third cell layer (of five) composing the epidermis, or outer surface of skin.
Acquired icthyosis has been associated with internal disease including malignancies, autoimmune/inflammatory, metabolic, endocrine, and infectious diseases, and medication use.
What Is Acquired Ichthyosis In Celiac Disease and/or Gluten Sensitivity?
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Patel N, Spencer LA, English JC 3rd, Zirwas MJ. Acquired ichthyosis. J Am Acad Dermatol. 2006 Oct;55(4):647-56. ↩