Autoimmune Disorders

What Is Systemic Lupus Erythematosus? Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that is characterized by involvement of multiple organs due to the production of antibodies to components of the cell nucleus.1 SLE has an unpredictable course of acute ...

What Is Sjögren’s Syndrome? Sjögren’s syndrome is a systemic inflammatory autoimmune disease with a chronic, progressive course that primarily attacks the lacrimal glands of the eye and the salivary glands of the mouth, which are exocrine glands. Exocrine glands secrete the substances they ...

What Is Primary Addison’s Disease? Addison’s disease is an autoimmune destruction of the adrenal glands by autoantibodies that target the adrenal cortex, or outer part of these glands, and is characterized by a slow progressive failure of the adrenal glands ...

What Is Dermatitis Herpetiformis? Dermatitis herpetiformis (DH) is an autoimmune extremely itchy, painful bullous skin rash (blistering eruptions) arising from the underlying dermis layer of skin as a consequence of gluten sensitivity. Dermatitis herpetiformis is characterized by multiple intensely itchy, ...

What Is Dermatomyositis? Dermatomyositis is a rare autoimmune systemic disease of the connective tissue that is characterized by inflammatory and debilitating degenerative changes in the muscles and in the skin.  Dermatomyositis results in symmetric, proximal muscle weakness of limbs (upper arms and ...

What Is Autism and Learning Disabilities? Autism and learning disabilities constititute a non-progressive psychiatric syndrome appearing in childhood characterized by withdrawal from communication with others often accompanied by repetitive or primitive behaviors. Primary gastrointestinal pathology may play an important role ...

What Are Autoimmune Disorders? Autoimmune disorders refer to those conditions that involve an abnormal immune attack on the body’s own tissues perpetuated by the production of autoantibodies directed against the body, or “self.” Auto means self. Q: Why does the ...

What Is Autoimmune Thyroiditis (Hypothyroidism)? Autoimmune thyroiditis, also called Hashimoto’s thyroiditis or Hashimoto’s Disease, is an autoimmune destruction of thyroid tissue characterized by insufficient thyroid hormone circulating in the body that causes formation of a goiter (enlarged thyroid gland) and ...

What Is Alopecia Areata? Alopecia areata is an autoimmune attack on hair follicles characterized by sudden hair loss involving scalp or beard, although any hairy area may be affected. Areas of hair loss have a patchy pattern with sharply defined ...

What Is Polymyositis? Polymyositis is a body-wide connective tissue disease resulting from autoimmune attack of skeletal muscles that is characterized by inflammatory and degeneratory changes. The course is unpredictable being marked by spontaneous flare-ups and remissions. Polymyositis can begin slowly or abruptly according ...

What Is Juvenile Idiopathic Arthritis? Juvenile idiopathic arthritis (JIA) is a rheumatic disorder characterized by chronic, inflammatory disease of large and small synovial joints and other organs in children under age 16 years. Growth and development may be impaired in ...

What Is Vitiligo? Vitiligo is a pigmentation disorder of the skin characterized by permanent loss of melanocytes in defined areas and, in some patients, antibodies to melanin. Vitiligo has significant psychological impact if occurring before adulthood.1 Q: What are melanocytes? A: ...

 What Is Psoriasis? Psoriasis is a chronic, autommune relapsing skin disorder characterized by scaling, erythema (redness), and less commonly, pustulation.1  The body surface area affected and the degree to which psoriasis is a problem varies considerably among patients and over time.2 Often ...

What Is Scleroderma? Scleroderma is a chronic skin manifestation of progressive systemic sclerosis characterized by generalized thickened, edematous skin firmly bound to subcutaneous tissue which causes limited movement. Systemic sclerosis a connective tissue disease that involves destructive changes in the ...

What Are Anti-Endomysium Antibodies? Anti-endomysium antibodies (EmA) are connective tissue autoantibodies produced in persons who have inherited the genes for celiac disease, an autoimmune disease, and are reacting to gluten in their diet. Autoantibodies are abnormal in that they attack ...