Hyposplenism: definition Posted by: Cleo Libonati, RN, BSN in DICTIONARY 0 2,513 Views The condition of having lost spleen tissue, called atrophy of the spleen. Antibody Disorders Blood Cells Encapsulated Bacterial Infection Glossary. Hyposplenism Spleen Disorders 2013-04-10 Cleo Libonati, RN, BSN