Autoimmune Disorders

This category comprises autoimmune disorders caused by an abnormal immune system attack against the body’s own tissue(s).

Almost half of autoimmune disorders occur with other diseases. Some are organ specific like autoimmune thyroid disease which attacks the thyroid gland, whereas others affect multiple organs and/or are associated with systemic manifestations, such as systemic lupus erythematosus.

Anti-tissue Transglutaminase Antibodies (tTG) Present In Blood

What Are Anti-tissue Transglutaminase Antibodies? Anti-tissue transglutaminase antibodies (anti-tTG) are connective tissue autoantibodies and can be detected in blood samples from affected persons who are reacting to gluten in the diet. Autoantibodies are abnormal because they attack the body’s own ...

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Autoimmune Polyglandular Syndromes 

What Are Autoimmune Polyglandular Syndromes? Autoimmune polyglandular syndromes (APS) are rare clusterings of two or more endocrine and non-endocrine autoimmune disorders in the same affected person. Polyglandular is somewhat of a misnomer since many of the manifestations of the diseases ...

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Juvenile Autoimmune Thyroid Disease

What Is Juvenile Autoimmune Thyroid Disease? Juvenile autoimmune thyroid disease is an autoimmune disorder occurring in childhood that targets and damages the thyroid gland, often causing goiter. It is characterized by abnormal circulating thyroid hormone levels in the bloodstream. Recent evidence ...

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Dermatitis Herpetiformis In Childhood

What Is Dermatitis Herpetiformis In Childhood? Dermatitis herpetiformis in childhood is an inflammatory skin manifestation of celiac disease in which immunoglobulin A (IgA) autoantibodies target components of the skin, leading to blister formation caused by ingestion of gluten in the diet.   Dermatitis ...

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Chronic Bullous Dermatosis of Childhood or Linear IgA Dermatosis

What Is Chronic Bullous Dermatosis Of Childhood? Chronic bullous dermatosis of childhood, also termed linear IgA dermatosis, is the most common acquired autoimmune blistering disorder of childhood and is characterized by itchy, urticated papules and plaques as well as polycyclic lesions (merged ...

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Juvenile Diabetes (Type 1 Diabetes Mellitus)

What Is Juvenile Type 1 Diabetes Mellitus? Juvenile diabetes is type I diabetes mellitus that begins in childhood or before the age of 25 years. It is an inherited inflammatory autoimmune disease of the pancreas in which anti-islet autoantibodies destroy the ...

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IgA Nephropathy

What Is IgA Nephropathy? IgA nephropathy, also called Berger’s disease, is a primary renal disease that results when immunoglobulin A (IgA) forms deposits in the glomeruli, where it creates inflammation. IgA nephropathy is characterized by recurrent hematuria (blood in urine), mild proteinuria ...

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Psoriatic Arthritis

What Is Psoriatic Arthritis? Psoriatic arthritis is a joint manifestation of psoriasis, a systemic autoimmune disease, characterized by asymmetric involvement in one or more joints, especially affecting the distal phalangeal joints of fingers and toes (joints nearest nails). In some ...

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Hair, Fine With Rough Texture

What Is Fine Hair With Rough Texture? Fine hair (lower diameter across the width) with rough texture is an abnormal hair shaft feature altered from the normal diameter and smooth quality of hair. Q: What is the normal diameter and smooth quality of ...

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Autoimmune Disorders In Dermatitis Herpetiformis

What Are Autoimmune Disorders? Autoimmune disorders refer to those conditions that involve an abnormal attack on the body’s own tissues perpetuated by the production of autoantibodies directed against self. Q: What happens when autoantibodies attack the body’s own tissues? A: ...

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Gastrointestinal Complications Of Type I Diabetes Mellitus

gastrointestinal complications in diabetes symptom in gluten and celiac disease

What Are Gastro-Intestinal Complications Of Type 1 Diabetes? Gastrointestinal complications of type I diabetes mellitus are functional or organic changes that result from diabetes affecting every organ of the gastrointestinal tract. Q: How do gastrointestinal tract complications affect diabetes? A: Impaired ...

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Diabetes Mellitus, Type I

What Is Type I Diabetes Mellitus? Type 1 diabetes mellitus (T1DM), also termed type 1A, is an inherited autoimmune disorder in which anti-islet autoantibodies destroy the islet cells of the pancreas that secrete insulin hormone. Type 1 diabetes mellitus was formerly ...

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Autoimmune Hepatitis

  What Is Autoimmune Hepatitis? Autoimmune hepatitis is an autoimmune attack against liver cells that is characterized by inflammation and results in chronic liver disease which includes low blood albumin and cirrhosis. Autoimmune hepatitis is diagnosed by detection of autoantibodies ...

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Primary Sclerosing Cholangitis 

What Is Primary Sclerosing Cholangitis? Primary sclerosing cholangitis (PSC) is an uncommon, slowly progressive bile duct disease that results in stagnation or build-up of bile in the liver, called cholestasis. Primary sclerosing cholangitis is characterized by sclerosis, or scarring inflammation ...

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Autoimmune Cholangitis

What Is Autoimmune Cholangitis? Autoimmune cholangitis is a rare inflammatory self-targeted disease of the biliary tract produced by high levels of immunoglobulin G (IgG) antibodies and antinuclear antibodies (ANA). Autoimmune cholangitis is characterized by progressive inflammation and scarring that leads to ...

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