Esophagus: definition Posted by: Cleo Libonati, RN, BSN in DICTIONARY 0 2,009 Views A hollow muscular tube located in the middle of the chest that connects the mouth with the stomach and performs swallowing through highly coordinated muscle actions called peristslsis that quickly move food into the stomach at 2-3 cm per second. Glossary. 2013-09-09 Cleo Libonati, RN, BSN