FoxP3+ T cells represent a major subset of regulatory T cells. They can be produced as natural or induced cells.
FoxP3+ T cells are made in the thymus gland as natural FoxP3+ T cells and periphery as induced FoxP3+ T cells.
Both natural and induced FoxP3+ regulatory T cells are highly effective in suppression of intestinal inflammation.1
Sources:- Kang SG, Wang C, Matsumoto S, Kim CH. High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation. Gastroenterology. 2009 Oct;137(4):1391-402.e1-6. doi: 10.1053/j.gastro.2009.06.063. Epub 2009 Jul 24. [↩]