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A therapy for celiac disease is one step closer. ImmunogenX purchased the license for Alvine Pharmaceuticals’ medicine, ALV003, which degrades gluten before it can be digested and absorbed by the intestines. The following press release was distributed by ImmunogenX.
“Glutenase for in-vivo gluten degradation is a leading candidate for celiac disease ImmunogenX™, a biopharmaceutical company focused on the diagnosis and treatment of autoimmune and gastrointestinal diseases, today announced that it has completed the acquisition of the non-cash assets of Alvine Pharmaceuticals.
This includes Latiglutenase (formerly known as ALV003 and renamed IMGX003), an orally administered mixture of two recombinant gluten-specific proteases that degrades gluten proteins into small physiologically irrelevant fragments. The technology is backed by over 50 issued or pending patents, has been extensively studied in Phase I and Phase 2 clinical trials, and is the only CD treatment that has demonstrated histologic success as well as symptomatic improvements in
Last month, Senator Ted Cruz, one of the Republican candidates for President of the United States made waves by clumsily associating gluten-free with political correctness.
“That’s why the last thing any commander should need to worry about is the grades he is getting from some plush-bottomed Pentagon bureaucrat for political correctness or social experiments — or providing gluten-free MREs,” Cruz said.
Actually, I would tell Senator Cruz that gluten-free MRE’s are possibly the first thing every commander should worry about.
In 2007, I attended the American Dietetic Association’s annual conference in Philadelphia to promote our book, Recognizing Celiac Disease.
Our booth was approached by a dietitian who also happened to be a uniformed Lt. Colonel in the US Army. He asked me about gluten sensitive enteropathy (celiac disease) and was specifically interested in gluten-free rations for troops.
Alba Therapeutics has been working on a therapy for celiac disease the past 8 years. Alba’s therapy, Larazotide Acetate, is the first to reach phase 3 clinical trials, where it will be given to large groups of people.
A real therapy for celiac disease is one step closer. Alba just sent us the following press release concerning their deal with Innovate Biopharmaceuticals to produce the therapy.
Gluten sensitivity and celiac disease causes over 300 signs, symptoms associated disorders and complications. Millions of people around the world are affected, but the rate of diagnosis is low. Most people and doctors do not realize how many symptoms and illnesses gluten causes.
The most concentrated stored energy in food. Each gram (g) supplies 9 calories of energy. Fats are digested to fatty acid and glycerol molecules and serve as a carrier to absorb the fat-soluble vitamins A,…
Vitamin E is not a single vitamin but naturally occurs as a fat-soluble vitamin family that consists of at least 8 distinct molecules.
These molecules include 4 tocopherols (alpha, beta, gamma, and delta) and 4 tocotrienols (alpha, beta, gamma, and delta).
Generally, tocotrienols are more active against chronic disease while tocopherols are more protective of the nervous system.
Vitamin E (for short) is a powerful antioxidant that protects cell membranes and other fat-soluble compounds from oxidative damage by free radicals (molecules that damage cells).
Q: How does vitamin E protect cells from oxidative damage by free radicals?
A: As an example, the oxidative damage to low density cholesterol (LDL – bad type) appears to lead to the deposition of cholesterol in the arterial wall (plaque formation) leading to atherosclerotic disease, commonly called hardening of the arteries.
Regarding inflammation, mast cells are activated by oxidized LDL which results in increased expression of inflammatory cytokines. This finding suggests that vitamin E antioxidant activity in reducing oxidation of LDL lipoprotein may also reduce mast cell activation. Mast cells reside near small blood vessels and, when activated, release potent mediators involved in allergy and inflammation.1
In neutralizing free radicals, vitamin E itself is oxidized (changed) to a free radical. Importantly, conversion of vitamin E back to the original form occurs by reaction with vitamin C. These two vital anti-oxidants go hand in hand.
Vitamin E is essential for normal cerebellar brain function (lower brain), peripheral nerve health and healthy skin.
What Is Vitamin E Deficiency In Celiac Disease and/or Gluten Sensitivity?
Sources:
Shaik-Dasthagirisaheb YB, Varvara G, Murmura G, Saggini A, Caraffa A, Antinolfi P, Tete’ S, Tripodi D, Conti F, Cianchetti E, Toniato E, Rosati M, Speranza L,Pantalone A, Saggini R, Tei M, Speziali A, Conti P, Theoharides TC, Pandolfi F. Role of vitamins D, E and C in immunity and inflammation. J Biol Regul Homeost Agents. 2013 Apr-Jun;27(2):291-5. [↩]
Gluten makes people sick, through celiac disease, gluten sensitivity or allergy. But, where do you find the medical research that proves it, especially to skeptics? This short video shows you where to go.
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