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Stroke in Childhood 

e4789565d1b49c3541a6a51b31ab8b30What Is Stroke In Childhood?

[dropcap]S[/dropcap]troke in childhood is a medical emergency during which blood flow to an area of the brain is stopped, causing infarction or death of the area of cells in the brain fed by the blocked artery. Stroke is characterized by loss of muscle and brain function according to the location of the lost cells.

The brain is a highly active metabolic and complex organ of our body that performs important functions, therefore, any disruption in its normal functioning can have devastating effects on whole body.

After stroke, an immune response is initiated that leads to production of proinflammatory cytokines (chemicals) and gathering of various inflammatory cells like neutrophils, T-cells, macrophage, and monocytes to the affected area that exacerbate or worsen the ischemic (oxygen starved) injury.1

Arterial ischemic stroke is an important cause of acquired brain injury in children.2 This stroke results from loss of adequate blood flow through an artery that supplies the affected area of the brain with oxygen and nutrients.

A recent study found the majority of  children (85%) had focal features (most commonly one sided weakness or paralysis) at presentation to their medical practitioner. Seizures were more common in younger children a year old or younger and headache was more common in children 5 years or older.3

Who is at Risk in the General Population?

  • A British study in 2014 found the crude incidence of childhood arterial ischemic stroke was 1.60 per 100,000 per year.
  • The incidence of arterial ischemic stroke was highest in children aged under 1 year (4.14 per 100,000 per year).
  • There was no difference in the risk of arterial ischemic stroke between sexes.
  • Asian and black children were at higher risk than were white children.3

What Is Stroke in Childhood In Celiac Disease and/or Gluten Sensitivity?

Sources:
  1. Andrabi SS, Parvez S, Tabassum H. Melatonin and Ischemic Stroke: Mechanistic Roles and Action. Adv Pharmacol Sci. 2015;2015:384750. doi: 10.1155/2015/384750. Epub 2015 Sep 7. [↩]
  2. Mallick AA, Ganesan V, Kirkham FJ, et al. Childhood arterial ischaemic stroke incidence, presenting features, and risk factors: a prospective population-based study. Lancet Neurol. 2014 Jan;13(1):35-43. doi: 10.1016/S1474-4422(13)70290-4. Epub 2013 Dec 2. [↩]
  3. Mallick AA, Ganesan V, Kirkham FJ, et al. Childhood arterial ischaemic stroke incidence, presenting features, and risk factors: a prospective population-based study. Lancet Neurol. 2014 Jan;13(1):35-43. doi: 10.1016/S1474-4422(13)70290-4. Epub 2013 Dec 2. [↩] [↩]

Insomnia

insomnia gluten celiac disease symptomWhat Is Insomnia?

[dropcap]I[/dropcap]nsomnia is a distressing sleep disorder that includes inability to fall asleep, inability to stay asleep, and inability to get deep sleep depending on the type of insomnia.

Q: What are the types of insomnia?

A: There are two types of insomnia: primary or secondary which have different causes.

1. Primary insomnia is characterized by sleeplessness due to reduction of synthesis of neurotransmitters (brain chemicals) in the central nervous system (brain) required for sleep, especially melatonin. Melatonin is produced during the night hours by the pineal gland from tryptophan, an essential amino acid derived from food.

Neurotransmitters are released when the axon terminal of a presynaptic neuron (nerve cell) is stimulated and acts by stimulating or inhibiting a target nerve cell.

2. Secondary insomnia has many causes. It can be a feature of malnutrition, lack of exercise, heartburn, mental disorders such as dementia and psychosis, emotional disorders such as depression and anxiety, guilt, worry, many conditions that involve itchiness, pain, disability, and a side effect of certain medications.

What Is Insomnia In Celiac Disease and/or Gluten Sensitivity?