Chronic Fatigue Syndrome: definitionby Cleo Libonati, RN, BSNApril 8, 2013A debilitating illness characterized by persistent or relapsing overwhelming and incapacitating fatigue not relieved by rest, having a definite onset and often accompanied by numerous symptoms involving various body systems. Tags:Glossary. Leave a Reply Cancel replyYour email address will not be published. Required fields are marked *Name * Email * Website Comment * Δ