What Is Magnesium?

M agnesium is an essential mineral predominantly found in the body within cells, where it is vital for their functions.

Here is a summary of what magnesium does in our body:

1. Co-factor for over 300 enzymes involved in the metabolism of food components and synthesis of many compounds.
2. Required for nerve transmission.
3. Required for muscle activity (acts to relax muscles in opposition to calcium which acts to contract).
4. Acts to maintain heart rhythm.
5. Required for membrane transport and interactions.
6. Required for glucose metabolism and energy production within cells.
7. Component of bone mineralization and tooth formation.
8. Plays a key role in calcium and phosphorus metabolism and management by parathyroid hormone.
9. Maintains the structural and functional integrity of vital eye tissues such as lens.¹

Only 1% of magnesium is found in blood, but the body must keep blood levels of magnesium constant.

What Is Magnesium Deficiency In Celiac Disease and/or Gluten Sensitivity?

Sources:

1. Agarwal R, Iezhitsa I, Agarwal P, Spasov A. Magnesium deficiency: does it have a role to play in cataractogenesis? Exp Eye Res. 2012 Aug; 101:82-9. doi: 10.1016/j.exer.2012.05.008. [↩]

What Is Iron?

I ron is an essential mineral that is required for normal body function.

Almost two-thirds of iron in the body is found in hemoglobin, the protein in red blood cells that carries oxygen to tissues. Smaller amounts of iron are found in myoglobin, a protein that helps supply oxygen to muscle, and in enzymes that assist biochemical reactions.

Iron is also found in proteins that store iron for future needs and that transport iron in blood.

Q: How are iron stores regulated?

A:Iron stores are regulated by intestinal iron absorption.¹That is, whenever iron is needed, more iron is absorbed than when iron is sufficient. This mechanism prevents excess iron in the body which is harmful.

In the brain, iron is necessary to ensure oxygenation and to produce energy in the cerebral parenchyma (via cytochrome oxid. ase), and for the synthesis of neurotransmitters and myelin.

Iron concentrations in the umbilical artery are critical during the development of the fetus, and in relation with the IQ in the child.²

What Is Iron Deficiency In Celiac Disease and/or Gluten Sensitivity?

Sources:

1. http://ods.od.nih.gov/factsheets/Iron-HealthProfessional accessed 12/11/12 [↩]
2. Bourre JM. Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. J Nutr Health Aging. 2006 Sep-Oct; 10(5):377-85. [↩]

What Is Chromium?

C hromium is a mineral that the body absolutely requires in trace amounts for normal metabolism, meaning the physical and chemical processes by which energy is produced and used.

Chromium is especially involved in the use of glucose sugar and lipids such as cholesterol and the effectiveness of insulin hormone.

Q: How is chromium involved in the use of glucose?

A: Very small amounts of chromium are required to enable insulin to move glucose from the bloodstream into cells for use as energy.

Insulin is a hormone that controls the use and storage of glucose in two ways: 1) lowers a rise of glucose in blood after meals by moving it out of the bloodstream into body cells, especially muscle cells and 2) limits the release of glucose from the liver between meals. Insulin is produced by beta cells on the surface of the pancreas.

To date, the molecular mechanism by which chromium affects glucose and lipid metabolism is still unclear.¹

What Is Chromium Deficiency In Celiac Disease and/or Gluten Sensitivity?

Sources:

1. Lewicki S, Zdanowski R, Krzyżowska M, Lewicka A, Dębski B, Niemcewicz M, Goniewicz M. The role of Chromium III in the organism and its possible use in diabetes and obesity treatment. Ann Agric Environ Med. 2014 Jun 10;21(2):331-335. [↩]

What Is Copper Deficiency?

C opper is an essential trace element that is required for a number of enzymes which are necessary for normal metabolic function.

In the body almost all the copper is present as a component of copper proteins which are produced and controlled by the liver.

Q: How does the liver control copper?

A: The liver maintains proper copper balance by binding free copper to proteins and by excreting excess copper as part of bile that is then emptied into the intestinal tract and excreted in stool.

Metabolic balance studies have demonstrated that daily copper losses are approximately 1.3 mg/day.¹

Among its specific functions listed below, copper is essential for energy production, blood and nerve functions, blood components, immunity, and collagen tissue. The copper enzyme, lysyl oxidase, is involved in the cross-linking of collagen in forming the framework for depositing calcium and other minerals to build and repair bone.

Animal studies suggest that adequate copper levels during pregnancy are critical to development of higher brain function in the offspring.²

What Is Copper Deficiency In Celiac Disease and/or Gluten Sensitivity?

Sources:

1. Williams DM. Copper deficiency in humans. Semin Hematol. 1983 Apr; 20(2):118-28. [↩]
2. Fisgin T, Yarali N, Duru F, Usta B, Kara A. Hematologic manifestation of childhood celiac disease. Acta Haematol. 2004;111(4):211-4. [↩]

What Is Calcium?

C alcium is the most abundant mineral in the body, with 99% residing in teeth and bones where it constitutes 40% of skeletal bone weight along with 45% phosphorus.

As a component of hard tissues, calcium fulfills a structural role to maintain body size and acts as attachments for musculoskeletal tissues.

Q: What does the non-skeleton calcium do in the body?

A: The remaining 1% of calcium is present in blood and soft tissues. Calcium levels in the blood are maintained within very strict limits by dietary intake, hormonal regulation and a rapidly exchangeable pool in bone tissue. The many important functions are described below.

What Is Calcium Deficiency In Celiac Disease and/or Gluten Sensitivity?

What Is Linoleic Acid?

L inoleic acid is an essential omega-6 fatty acid that comes from plant sources. Essential means the body must have it to maintain health and life sustaining functions. Omega-6 fatty acids are polyunsaturated.

Among its many vital roles in the body, linoleic acid composition of intestinal membranes is important for epithelial cell function and disturbances may contribute to the pathophysiology of celiac disease.¹

Q: What are epithelial cells?

A: Epithelial cells make up the surface mucosa of the digestive tract and also the respiratory tract, urinary tract and genital tract.

Linoleic acid is an important building material for the eicosanoids, a large group of highly bioactive hormone-like substances including prostaglandins, leukotrienes, and thromboxanes that are involved in blood clotting, inflammation, and vasoconstriction.²

What Is Linoleic Acid Deficiency in Celiac Disease?

Sources:

1. Steel DM, Ryd W, Ascher H, Strandvik B. Abnormal fatty acid pattern in intestinal mucosa of children with celiac disease is not reflected in serum phospholipids. J Pediatr Gastroenterol Nutr. 2006 Sep; 43(3):318-23. [↩]
2. Richardson AJ. The importance of omega-3 fatty acids for behavior, cognition, and mood. Scandinavian Journal of Nutrition. 2003; 47(2):92-8 [↩]

What Is Arachidonic Acid?

A rachidonic acid is a major essential (must have/can’t make) omega-6 fatty acid.

Structurally, arachidonic acid is a key component of nerve membranes, together with docosahexaenoic acid (DHA), a major opposing omega-3 fatty acid, making up 15-20% of the brain’s dry mass and more than 30% of the retina.

In healthy human volunteers, positron emission tomography (PET) has shown that the normal human brain consumes 17.8 mg/day of arachidonic acid.¹

Arachidonic acid is particularly concentrated in highly active membranes such as nerve synapses (junctions) and in photoreceptors in the eye retina.²

Arachidonic acid is an important building substance for the eicosanoids.

Q: What function do the eicosanoids have that are derived from arachidonic acid?

A: Eicosanoids are a large group of highly bioactive hormone-like substances including prostaglandins, leukotrienes, and thromboxanes that are involved in blood clotting, inflammation, and vasoconstriction. Eicosanoids derived from arachidonic acid are pro-inflammatory, pro-blood clotting, and constrict blood vessels in opposition to those derived from the omega-3 fatty acids which do the opposite in order to keep a balance in the body.

What Is Arachidonic Acid Deficiency In Celiac Disease and/or Gluten Sensitivity?

Sources:

1. Rapoport SI. Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):153-6. Epub 2008 Oct 29. [↩]
2. Richardson AJ. The importance of omega-3 fatty acids for behavior, cognition, and mood. Scandinavian Journal of Nutrition. 2003;47(2):92-8. [↩]

What Is DHA?

D ocosahexaenoic acid (DHA) is an essential omega-3 fatty acid that is abundant in the brain, being crucial in brain structure. As such DHA is a key component of neuronal membranes together with arachidonic acid (a major opposing omega-6 fatty acid), making up 15-20% of the brain’s dry mass.

This polyunsaturated fatty acid is obtained from fish sources of food.

In healthy human volunteers, positron emission tomography (PET) has shown that the normal human brain consumes 4.6 mg/day of DHA.¹

DHA is particularly concentrated in highly active membranes such as nerve synapses (junctions) and photoreceptors in the eye (retina).

Q: How much DHA is in the retina?

A: DHA makes up more than 30% of the retina.²

In other roles, DHA is an  important building material for the eicosanoids, a large group of highly bioactive hormone-like substances including prostaglandins, leukotrienes, and thromboxanes that are involved in blood clotting, inflammation, and vasoconstriction.

DHA has been shown to increase insulin sensitivity as opposed to the opposite problem of insulin resistance, to improve muscle mass, and protect against non-alcoholic fatty liver disease.³

Egert et al. in a study of people aged 19 to 43 years with normal cholesterol showed that DHA intake significantly increased serum HDL (good) cholesterol. Also, DHA significantly decreased fasting serum triglycerides.⁴

What Is DHA Deficiency In Celiac Disease and/or Gluten Sensitivity?

Sources:

1. Rapoport SI. Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):153-6. Epub 2008 Oct 29. [↩]
2. Richardson AJ. The importance of omega-3 fatty acids for behavior, cognition, and mood. Scandinavian Journal of Nutrition. 2003;47(2):92-8 [↩]
3. Espinosa A, Valenzuela R, González-Mañán D, D’Espessailles A, Guillermo Gormaz J, Barrera C, Tapia G. Prevention of liver steatosis through fish oil supplementation: correlation of oxidative stress with insulin resistance and liver fatty acid content. Arch Latinoam Nutr. 2013 Mar;63(1):29-36. [↩]
4. Egert S, Kannenberg F, Somoza V, et al. Dietary alpha-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. J Nutr. 2009;139:861–868. doi: 10.3945/jn.108.103861 [↩]

What Is Alpha-Linolenic Acid?

A lpha-linolenic acid is an essential (need/can’t make) polyunsaturated omega-3 fatty acid that must be obtained in the diet. Alpha-linolenic acid is found in plant sources only.

Alpha-linolenic acid is required for normal brain function and nervous system health. It is an important building material for the eicosanoids.

Q: What are eicosanoids?

A: Eicosanoids are a large group of highly bioactive hormone-like substances including prostaglandins, leukotrienes, and thromboxanes that are involved in blood clotting, inflammation, and vasoconstriction (constriction of blood vessels).

Alpha-linolenic acid is a “parent” fatty acid because if sufficient amounts are present in the body, it can be used to produce both eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), two other critical omega-3 fatty acids.¹ However, this conversion is limited. In healthy individuals, the conversion rate of ALA to EPA is less than 5 to 10% and ALA to DHA is only 2 to 5%.

Additionally, a deficient level of the mineral selenium can interfere with the conversion of alpha-linolenic acid into EPA and DHA. Also, folic acid supplement has been shown to increase omega-3 status and, conversely, to decrease omega-3 when folic acid is in deficient in animal models.

What Is Alpha-Linolenic Acid Deficiency?

Sources:

1. Richardson AJ. The importance of omega-3 fatty acids for behavior, cognition, and mood. Scandinavian Journal of Nutrition. 2003; 47(2):92-8 [↩]

What Is Glucose?

G lucose is the most important simple sugar in human metabolism because it is the primary source of energy for most cells of the body and is particularly required by the brain.

Q: Where does glucose get energy?

A: The energy in glucose originally comes from the sun. Plants capture and bind the sun’s energy by means of photosynthesis. We eat the plants directly or indirectly by eating food from animals  that have eaten plants.

Energy from glucose is obtained in the body from its reaction with oxygen (oxidation) that occurs in power producing mitochondria within cells.¹

Humans cannot live without an adequate supply of glucose to the body.

What Is Glucose Deficiency In Celiac Disease and/or Gluten Sensitivity?

Sources:

1. http://hyperphysics.phy-astr.gsu.edu/hbase/organic/sugar.html accessed 11 14 12 [↩]