An inherited disease in which much of the genetic susceptibility maps to the HLA region on chromosome 6, as approximately 95% of celiac disease patients carry an almost identical HLA DQ2 heterodimer (DQA1*0501 DQB1*0201).
In most individuals who are negative for HLA DQ2, this disease is associated with the class II alleles DQA1*0301 and DQB1*0302, which encode a DQ8 molecule linked to DR4 haplotypes.1
Sources:- Mazzarella G. Effector and suppressor T cells in celiac disease. World J Gastroenterol. 2015 Jun 28;21(24):7349-56. doi: 10.3748/wjg.v21.i24.7349. [↩]