{"id":812,"date":"2013-04-29T19:48:06","date_gmt":"2013-04-29T19:48:06","guid":{"rendered":"http:\/\/www.mynutriguide.com\/?p=812"},"modified":"2019-12-26T12:43:46","modified_gmt":"2019-12-26T17:43:46","slug":"unexplained-hypogonadism-in-adults-2","status":"publish","type":"post","link":"https:\/\/glutenfreeworks.com\/health\/unexplained-hypogonadism-in-adults-2\/","title":{"rendered":"Hypogonadism In Adult Males That Is Unexplained \u00a0"},"content":{"rendered":"<div id=\"attachment_8283\" style=\"width: 176px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/hypothalamus.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-8283\" class=\"size-medium wp-image-8283\" src=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/hypothalamus-166x300.png\" alt=\"Courtesy quizlet.com\" width=\"166\" height=\"300\" srcset=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/hypothalamus-166x300.png 166w, https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/hypothalamus.png 259w\" sizes=\"auto, (max-width: 166px) 100vw, 166px\" \/><\/a><p id=\"caption-attachment-8283\" class=\"wp-caption-text\"><em>Courtesy quizlet.com<\/em><\/p><\/div>\n<h2>What Is Unexplained Adult Male Hypogonadism?<\/h2>\n<p style=\"text-align: justify\"><span class=\"dropcap\">H<\/span>ypogonadism in males is a distressing reproductive disorder characterized by inadequate production of male andogen hormones and\/or spermatozoa by the testes.<\/p>\n<p style=\"text-align: justify\"><strong>Q<\/strong>: How do andogens affect reproductive health?<\/p>\n<p style=\"text-align: justify\"><strong>A<\/strong>: Male androgen hormones control the development and maintenance of male sex organs and masculine secondary sex characteristics and are\u00a0<span style=\"font-size: 14px;line-height: 1.5em\">required for health, especially bone health.<\/span><span style=\"font-size: 14px;line-height: 1.5em\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: 14px;line-height: 1.5em\">Testosterone is the major andogen hormone. While most of this steroid is produced by the testes, some is also produced by the adrenal glands. In hypogonadism, the testoste<\/span><span style=\"font-size: 14px;line-height: 1.5em\">rone level in blood is 300 ng\/dl or below.\u00a0<\/span><\/p>\n<p style=\"text-align: justify\">Hypogonadism in men 45 years or older is significantly higher in men with hypertension, hyperlipidaemia, diabetes, obesity, prostate disease, and asthma or chronic obstructive pulmonary disease.<a href=\"#footnote_1_812\" id=\"identifier_1_812\" class=\"footnote-link footnote-identifier-link\" title=\"Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006 Jul;60(7):762-9.\">1<\/a><\/p>\n<p style=\"text-align: justify\">Interestingly, a 2014 study by Shortridge et al. on experiences and treatment of men with hypogonadism seeking care found that some symptoms continued despite treatment, and therapy was discontinued at a high rate, which men generally attributed to cost and perceptions of efficacy.<a href=\"#footnote_2_812\" id=\"identifier_2_812\" class=\"footnote-link footnote-identifier-link\" title=\"Shortridge EF, Polzer P, Donga P, Blanchette CM, Fang Y, Burudpakdee C, Carswell B. Experiences and treatment patterns of hypogonadal men in a U.S. health system. Int J Clin Pract. 2014 Mar 28. doi: 10.1111\/ijcp.12418.\">2<\/a> Compare this to the reversal seen in celiac men on gluten free diet.<\/p>\n<p style=\"text-align: justify\">Who is Affected in the General Population? P<span style=\"font-size: 14px;line-height: 1.5em\">revalence rate of hypogonadism was 38.7% in<\/span><span style=\"font-size: 14px;line-height: 1.5em\">\u00a0a study of 2162 primary care patients; 836 were hypogonadal, with 80 receiving testosterone.<a href=\"#footnote_1_812\" id=\"identifier_3_812\" class=\"footnote-link footnote-identifier-link\" title=\"Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006 Jul;60(7):762-9.\">1<\/a><\/span><\/p>\n<h2>What Is Unexplained Adult Male Hypogonadism In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p><!--more--><\/p>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\">Hypogonadism in males is associated with celiac disease and may be a presenting feature of untreated celiac disease.<\/li>\n<li style=\"text-align: justify\">Affected males show a picture of tissue resistance to androgens which responds to a gluten free diet.\u00a0Androgens are the male hormones \u00a0produced by the gonads (testicles) that are responsible for masculine features.<\/li>\n<li style=\"text-align: justify\">Androgen resistance and hypothalmic-pituitary dysfunction appear to be relatively specific to celiac disease and cannot be explained merely in terms of malnutrition or chronic ill-health.<a href=\"#footnote_3_812\" id=\"identifier_4_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: 2. Sex hormones. Gut. Feb 1983;24(2):127-35.\">3<\/a><\/li>\n<\/ul>\n<p style=\"text-align: justify;padding-left: 60px\"><strong>Q:<\/strong> What is the relationship between androgen resistance and hypothalmic-pituitary dysfunction?<\/p>\n<p style=\"text-align: justify;padding-left: 60px\"><strong>A:<\/strong> The hypothalmus, located in the brain,\u00a0is constantly monitoring male hormone levels in\u00a0<span style=\"font-size: 14px;line-height: 1.5em\">the bloodstream that are\u00a0<\/span><span style=\"font-size: 14px;line-height: 1.5em\">released by the testes. Normally, when levels are inadequate, the hypothalmus sends gonatotropin releasing hormone (LHRH) to\u00a0cause the\u00a0pituitary gland nearby to release FSH and LH stimulating hormones. These hormones travel by blood to the male gonads to regulate their function.\u00a0<\/span><\/p>\n<p style=\"padding-left: 60px;text-align: justify\"><span style=\"text-align: justify\">Follicle stimulating hormone (FSH) stimulates the development of sperm in the Sertoli cells.\u00a0<\/span>Luteinizing hormone (LH) stimulates the production of testosterone.\u00a0Testosterone secreted from the Leydig cells produces mature male characteristics and is responsible for proper sperm production.<\/p>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\">Exaggerated responses of FSH (89%) and LH (49%) to LHRH were found in celiacs with sub-total villous atrophy and were commonly found when basal gonadotropin concentrations were normal. LH response was closely linked to villous atrophy of the jejunum.<a href=\"#footnote_4_812\" id=\"identifier_5_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: III. Pituitary regulation. Clinical Endocrinology. Dec 1983;19(6):661-71.\">4<\/a><\/li>\n<li style=\"text-align: justify\">Hormone alterations are reversible upon the start of a gluten free diet, emphasizing the importance of early diagnosis.<\/li>\n<li style=\"text-align: justify\">As regards the nutritional aspects, the folic acid deficiency of celiac disease can affect rapidly proliferating tissues such as the seminiferous epithelium. Seminiferous epithelium refers to the cells (epithelia) that line the seminal vesicles, located in the testicles.<\/li>\n<li style=\"text-align: justify\">More attention should be paid to deficiencies of fat-soluble vitamins, such as A and D, observed in celiac disease because vitamin A is important for Sertoli cell function, as well as, for early spermatogenetic phases.<\/li>\n<li style=\"text-align: justify\">Vitamin E supports the correct differentiation and function of epidydimal epithelium, spermatid maturation and secretion of proteins by the prostate. The detection of early biomarkers of andrological or endocrinological dysfunctions should trigger timely strategies for prevention and treatment.<a href=\"#footnote_5_812\" id=\"identifier_6_812\" class=\"footnote-link footnote-identifier-link\" title=\"Stazi AV, Mantovani A. Celiac disease and its endocrine and nutritional implications on male reproduction. Minerva Medica. Jun 2004;95(3):243-54.\">5<\/a><\/li>\n<\/ul>\n<h2>How Prevalent Is Unexplained Adult\u00a0Male\u00a0Hypogonadism In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p style=\"text-align: justify\">Hypogonadism in males has increased frequency in males with untreated celiac disease.<a href=\"#footnote_5_812\" id=\"identifier_7_812\" class=\"footnote-link footnote-identifier-link\" title=\"Stazi AV, Mantovani A. Celiac disease and its endocrine and nutritional implications on male reproduction. Minerva Medica. Jun 2004;95(3):243-54.\">5<\/a><\/p>\n<h2>What Are The Symptoms Of Unexplained Adult Male Hypogonadism?<\/h2>\n<p style=\"text-align: justify\">Hypogonadism in males is marked by these symptoms:<\/p>\n<ul class=\"cp_bullet red\">\n<li style=\"text-align: justify\">Immature secondary sex characteristics, that is, deepening of the voice,\u00a0growth and development of genitals, arm pit and\u00a0pubic hair, and\u00a0development of male sweat glands.<\/li>\n<li style=\"text-align: justify\">Low or no sex drive.<\/li>\n<li style=\"text-align: justify\">Decreased muscle mass.<\/li>\n<li style=\"text-align: justify\">Reduced semen quality.<\/li>\n<li style=\"text-align: justify\">Possible loss of height due to osteoporosis because low testosterone cause bones to thin, increasing the risk of fractures.<\/li>\n<\/ul>\n<h2>How Does Unexplained Adult Male Hypogonadism In Celiac Disease and\/or Gluten Sensitivity Develop?<\/h2>\n<p style=\"text-align: justify\">Hypogonadism in males results from unclear etiology involving gluten exposure and deficiencies including zinc and vitamin A, vitamin E, and vitamin D.<a href=\"#footnote_5_812\" id=\"identifier_8_812\" class=\"footnote-link footnote-identifier-link\" title=\"Stazi AV, Mantovani A. Celiac disease and its endocrine and nutritional implications on male reproduction. Minerva Medica. Jun 2004;95(3):243-54.\">5<\/a>,<a href=\"#footnote_3_812\" id=\"identifier_9_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: 2. Sex hormones. Gut. Feb 1983;24(2):127-35.\">3<\/a><\/p>\n<h2>Does Unexplained Adult Male Hypogonadism Respond To Gluten-Free Diet?<\/h2>\n<p>Yes. Celiac disease-related hypogonadism responds to gluten free diet.<a href=\"#footnote_5_812\" id=\"identifier_10_812\" class=\"footnote-link footnote-identifier-link\" title=\"Stazi AV, Mantovani A. Celiac disease and its endocrine and nutritional implications on male reproduction. Minerva Medica. Jun 2004;95(3):243-54.\">5<\/a><\/p>\n<h2>6 Steps To Improve Adult Male Hypogonadism In Celiac Disease and\/or Gluten Sensitivity:<\/h2>\n<ul class=\"cp_check green\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>1<\/strong><\/span><\/span><strong><span style=\"color: #800000\">Remove the Trigger. Maintain a Strict, Nutritious Gluten Free Diet:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<b>Treatment<\/b>. This condition responds to the complete elimination of gluten, which is the required treatment that improves both male \u00a0hypogonadism\u00a0and gut health.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Gut health is the foundation to restore ALL health. Restored health will enable you to maintain a strict gluten free diet, just as other life tasks will be easier.<\/li>\n<li>A strict gluten free diet means removing 100% of wheat, barley, rye and oats from the diet.<\/li>\n<li>Cutting out bread and other obvious sources of gluten is not good enough for recovery. Even 1\/8th teaspoon of flour or bread crumb is enough to sustain the inflammation that is damaging your small intestine, causing increased permeability (leaky gut) and allowing undigested gluten to enter your body where it can damage structures and function, and instigate immune inflammatory responses.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Correct Your Individual Nutritional Needs.<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eat foods that can replenish missing nutrients. Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<li>Take nutritional supplements as needed.\u00a0Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Recovery<\/strong>. You should begin to feel better within a week and notice more energy as inflammation subsides and the \u00a0absorbing cells that make up the surface lining of your small intestine are better able to function.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Intestinal lining cells are replaced every 5 days. The healing process is like sunburn where the damaged surface layer of skin sloughs off and is replaced with new normal cells.<\/li>\n<li>Leaky gut normally resolves in two month after starting a gluten free diet and brings about a big improvement in health. Improvement in intestinal permeability precedes morphometric recovery (cell appearance and structure) of the small intestine in celiac disease.<a href=\"#footnote_6_812\" id=\"identifier_11_812\" class=\"footnote-link footnote-identifier-link\" title=\"Cummins AG, Thompson FM, Butler RN, et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease.&nbsp;Clinical Science. Apr 2001;100(4):379-86.\">6<\/a><\/li>\n<li>The intestinal lining may take up to a year to heal.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>2<\/strong><\/span><\/span><strong><span style=\"color: #800000\">\u00a0Reduce Inflammation. Foods to Eat and Foods Not to Eat:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\">Because gluten is inflammatory, eliminate OTHER inflammatory foods from your diet to reduce an additive effect to gluten. At the same time, try to eat foods that reduce inflammation (anti-inflammatory).<\/p>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Major Inflammatory Food Types That Reduce Healing<\/strong>:<\/p>\n<ul class=\"cp_bullet red\" style=\"text-align: justify\">\n<li><strong>Damaging Foods<\/strong>. In susceptible persons, includes corn, dairy (cow), and soy. Lactose, the sugar in any animal milk disrupts intestinal permeability causing leaky gut.<a href=\"#footnote_7_812\" id=\"identifier_12_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Allergenic Foods<\/strong>. Includes foods that trigger the immune sytem to produce IgE antibodies. Allergy testing is the usual way to discover these offending foods.<\/li>\n<li><strong>Shelf Stable Processed Foods.\u00a0<\/strong>Includes any that contain additives and preservatives. Look for them on the nutrition label of the box or package. Additives and preservatives also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_7_812\" id=\"identifier_13_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Fats.<\/strong>\u00a0Limit deep fried foods, trans-fats, saturated fats (animal fat\/butter), and EXCESSIVE omega-6 fatty acid oils like corn oil. Rancid fats, sodium caprate (a medium chain fat), and sucrose monester fatty acid (a food grade surfactant) induce significant disruption of the intestinal barrier that causes leaky gut.<a href=\"#footnote_7_812\" id=\"identifier_14_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a>.<\/li>\n<li><strong>Excessive Refined White Flours\u00a0<\/strong>(bran layer removed)<strong>.\u00a0<\/strong>Includes\u00a0products made from them such as cookies, bread, cakes, pies.\u00a0Bran contains the vitamins and minerals that metabolize grains and slows the otherwise rapid entry of sugar from their digestion into the bloodstream.\u00a0Also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_7_812\" id=\"identifier_15_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Refined Sugars.\u00a0<\/strong>\u00a0Includes white sugar, corn fructose and high fructose corn syrup.<\/li>\n<li><strong>Certain Spices<\/strong>. Includes paprika and cayenne pepper which disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_7_812\" id=\"identifier_16_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Alcohol and Caffeine<\/strong>. Disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_7_812\" id=\"identifier_17_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a>\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Important Anti-Inflammatory Food Types to Promote Health<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li><strong>Fruits<\/strong>.\u00a0Contain ample amounts of vitamins, minerals and phytochemicals which are\u00a0naturally occuring components in plants that detoxify toxins, carcinogens (reducing the risk by 50%) and mutagens.<\/li>\n<li><strong>Non-Starchy Vegetables.<\/strong>\u00a0Support intestinal integrity and provide ample amounts of vitamins, minerals and phytochemicals. Includes green leafy vegetables such as lettuce and kale, also onion, broccoli, garlic, and others.<\/li>\n<li><strong>High Quality Complex Carbohydrates<\/strong>. Provide vitamins, minerals, and fiber while boosting serotonin levels to help you relax and feel calm. Includes whole grains, legumes, and root vegetables such as carrots, parsnips, sweet potatoes, turnips, red beets, and others.<\/li>\n<li><strong>Antioxidants<\/strong>. Protect the body from inflammatory oxidant molecules that continually occur and\u00a0help us handle stress and reduce irritability. Includes vitamin C-containing foods such as lemon, grapefruit, apricot, Brussels sprouts and strawberries, and others. Also, includes vitamin E-containing foods such as\u00a0nuts, seeds, avocado, olive oil, and others. Cocoa is good, too.<\/li>\n<li><strong>Omega-3 Fatty Acids<\/strong>. Balance opposing omega-6 fatty acids and bad fats. Fish sources includes tuna, salmon, cod, and others. Plants sources include flax, chia seeds, canola oil, and others.<\/li>\n<li><strong>Probiotics.\u00a0<\/strong>Supply normal microbes needed for colon health and health of the body such as these fermented foods: yogurt, kefir, and unpasteurized apple cider vinegar.<\/li>\n<li><strong>Prebiotics\/ High Fiber Foods<\/strong>. \u00a0Food with fiber keeps our population of colonic microbes healthy.<\/li>\n<li><strong>Protective Herbs and Spices<\/strong>. \u00a0See below #6 below for examples.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">3<\/span>\u00a0Information Sheet You Can Take to Your Doctor or Other Health Professional:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\">Click here.<\/p>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><span style=\"color: #800000\"><strong><em><span class=\"dropcap\">4<\/span>\u00a0Manage Your Medications\u00a0Safely<\/em>:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">Certain medications deplete zinc, vitamin A, vitamin E, and vitamin D which promotes adult male hypogonadism. Ask your doctor or pharmacist about this possible adverse effect if you are taking any of the drugs listed below.\u00a0<strong>Do not stop prescribed medications without supervision.<\/strong><\/p>\n<p style=\"text-align: justify\">This is not a complete listing.<\/p>\n<p style=\"text-align: justify\"><strong>ANTACIDS \/ ULCER MEDICATIONS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Pepcid\u00ae, Tagamet\u00ae, Zantac\u00ae deplete Vitamin A, Vitamin D, Zinc.<\/li>\n<li>Magnesium and Aluminum Antacid preparations (Gaviscon\u00ae, Maalox\u00ae, Mylanta\u00ae) deplete\u00a0Vitamin A, Vitamin D, Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTIBIOTICS\u00a0<\/strong>disrupt intestinal permeability which complicates celiac disease.<\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>\u00a0Tetracyclines deplete Zinc.<\/li>\n<li>Cipro depletes Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTI-INFLAMMATORIES<\/strong>\u00a0disrupt intestinal permeability which complicates celiac disease.<\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Corticosteroids (Prednisone, Medrol\u00ae, Aristocort\u00ae, Decadron) deplete Vitamin D, Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTICONVULSANTS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Phenobarbital and Barbituates; and Dilantin\u00ae, Tegretol\u00ae, Mysoline\u00ae, Depakane\/Depacon\u00ae deplete Vitamin D, Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTIVIRAL AGENTS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Zidovudine (Retrovir\u00ae, AZT and other related drugs) deplete Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>CARDIOVASCULAR DRUGS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Antihypertensives (Catapres\u00ae, Aldomet) deplete Zinc.<\/li>\n<li>ACE Inhibitors (Capoten\u00ae, Vasotec\u00ae, Monopril\u00ae and others) deplete Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>CHOLESTEROL DRUGS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Colestid\u00ae and Questran\u00ae deplete Vitamin A, Vitamin D, Vitamin E, Beta-carotene.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>DIURETICS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Thiazide Diuretics (Hydrochlorothiazide, Enduron\u00ae, Diuril\u00ae, Lozol\u00ae, Zaroxolyn\u00ae, Hygroton\u00ae and others) deplete Zinc.<\/li>\n<li>Loop Diuretics (Lasix\u00ae, Bumex\u00ae, Edecrin\u00ae) deplete Zinc.<\/li>\n<li>Potassium Sparing Diuretics (Midamor\u00ae, Aldactone\u00ae, Dyrenium\u00ae and others) deplete Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>FEMALE HORMONES<\/strong>\u00a0disrupt intestinal permeability which complicate celiac disease.<\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Oral Contraceptives (Norinyl\u00ae, Ortho-Novum\u00ae, Triphasil\u00ae, and others) deplete Zinc.<\/li>\n<li>Oral Estrogen\/Hormone Replacement (Evista\u00ae, Prempro\u00ae, Premarin\u00ae, Estratab\u00ae and others) deplete Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>WEIGHT LOSS DRUGS THAT BIND FAT\u00a0<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Zenicol (Orlistat\u00ae) depletes Vitamin A, Vitamin D, Vitamin E, Beta-carotene.<\/li>\n<\/ul>\n<p style=\"text-align: justify\">\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">5<\/span>Nutritional Supplements To Help Correct Deficiencies:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">The type and quantity of nutritional supplements that may be needed depend on which nutrients are deficient.<\/p>\n<ul class=\"cp_bullet orange\" style=\"text-align: justify\">\n<li>Multivitamin\/mineral combination once a day is useful to improve overall nutrient levels. This is a safe dose, but always check with your doctor to avoid interactions with medications.<\/li>\n<li>Vitamin A as prescribed following blood test for status.<\/li>\n<li>Vitamin D3 as prescribed following blood test for status.<\/li>\n<li>Vitamin E as prescribed following blood test for status.<\/li>\n<li>Chelated zinc as prescribed.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Storage Note<\/strong>:\u00a0<em>Store container tightly sealed, away from heat, moisture and direct light to avoid loss of potency. That is, in a safe kitchen cabinet &#8211; not in the bathroom or on the kitchen table<\/em>.\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><span style=\"color: #800000\"><em><strong><span class=\"dropcap\">6<\/span>Manage Natural Remedies:\u00a0<\/strong><\/em><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Hydration<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eight glasses of water are recommended per day unless there is a contraindication such as kidney or heart disease. The Institute of Medicine recommends approximately 2.7 liters (91 ounces) of total water, from all beverages and foods, each day for women and 3.7 liters (125 ounces) daily of total water for men.<\/li>\n<li>If you are thirsty, drink water. Add fresh, squeezed lemon to water. Lemon is anti-inflammatory, alkalizing and provides vitamin C.<\/li>\n<li>Hydration Test: Urine should be pale yellow. Fingertips should be plump, without pruning but this may not be reliable when fingers are swollen with edema. Lips should be plump, without puckering. The feeling of thirst can be unreliable.<\/li>\n<li>What is wrong with soda, coffee, tea, and alcohol? These drinks are dehydrating, increase acid, and deplete nutrients.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Carminatives.\u00a0<\/strong>The following \u00a0anti-inflammatory\u00a0plant sources called carminitives help heal the digestive tract. They also tone the digestive muscles which improves peristalsis, thus aiding in the expulsion of gas from the stomach and intestine to relieve digestive colic and gastric discomfort.<\/p>\n<p style=\"text-align: justify\"><strong>Carminative Food Remedies<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Raspberry.<\/li>\n<li>Carrot is also a cleansing digestive tonic.<\/li>\n<li>Grape is also bile stimulating and a cleansing remedy for sluggish digestion and laxative.<\/li>\n<li>Redbeets also stimulate and improve digestion and are easily digested.<\/li>\n<li>Cabbage also stimulates and improves digestion and is also a liver decongestant.<\/li>\n<li>Lettuce also stimulates and improves digestion and is also an alterative, meaning it improves the function of organs involved with the digestion and excretion of waste products to bring about a gradual change.<\/li>\n<li>Potatoes are antispasmodic (due to atropine like properties) and a liver remedy.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Herb Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Sage is also a digestive, astringent, bile stimulant and energy tonic that heals the mucosa. \u00a0Drink as tea or use in cooking.<\/li>\n<li>Chamomile, lemon balm, and fennel, (as a tea) also help relieve nervous tension.<\/li>\n<li>Parsley also relieves indigestion.<\/li>\n<li>Rosemary as a tea and in cooking also is a nervous system tonic for stress and fatigue, bile stimulant, and can relieve headaches and indigestion.<\/li>\n<li>Thyme is also soothing remedy useful for stimulating digestion of rich, fatty foods.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Spice Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Cloves are also antispasmodic.<\/li>\n<li>Nutmeg is also useful for indigestion.<\/li>\n<li>Ginger.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Exercise Helps<\/strong>:<\/p>\n<p style=\"text-align: justify\">Exercise improves circulation and rids the body of toxins.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Walking is aerobic exercise that reconditions the whole body to improve stamina.\u00a0Read more about<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">\u00a0Exercise and Fitness<\/a>.<\/li>\n<li>Weight training builds muscle.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<li>Stretching improves flexibilty.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Note<\/strong>: Exercise is important, but the amount and type of exercise undertaken depends on your health. Your first priority is to heal. \n\t\t\t<\/div><\/div>\n<h2 style=\"text-align: justify\">What Do Medical Research Studies Tell About Unexplained Adult Male Hypogonadism In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<h4><strong>RESEARCH STUDY SUMMARIES<\/strong><\/h4>\n<p style=\"text-align: justify\"><b>\u201cVitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients.\u201d<\/b> This study aiming to assess the nutritional and vitamin\/mineral status of current &#8220;early diagnosed&#8221; untreated adult CD-patients in the Netherlands found that vitamin\/mineral deficiencies are still common in newly &#8220;early diagnosed&#8221; CD-patients.<\/p>\n<p style=\"text-align: justify\">Eighty (80) consecutively newly diagnosed adult CD-patients were included and a comparable sample of 24 healthy Dutch subjects was added to compare vitamin concentrations.\u00a0Some of the CD patients reported to have used vitamin and mineral supplements before diagnosis of CD was made: 18 (22.5%) a multivitamin, folic acid or vitamin B-complex, 7 (8.8%) iron supplements and 14 (17.5%) a calcium supplement.<\/p>\n<p style=\"text-align: justify\">Nutritional status and serum concentrations of select mineral and vitamins were made before prescribing gluten free diet. Almost all CD-patients (87%) had at least one value below the lower limit of reference. Specifically, for\u00a0vitamin A, 7.5% of patients showed deficient levels. Vitamin\/mineral deficiencies were counter-intuitively not associated with a (higher) grade of histological intestinal damage or (impaired) nutritional status. Extensive nutritional assessments seem warranted to guide nutritional advices and follow-up in celiac disease treatment.<a href=\"#footnote_8_812\" id=\"identifier_18_812\" class=\"footnote-link footnote-identifier-link\" title=\"Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, Mulder CJ, van Bodegraven AA. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients. 2013 Sep 30;5(10):3975-92. doi: 10.3390\/nu5103975.\">8<\/a><\/p>\n<p style=\"text-align: justify\">\u201c<strong>LH response was closely linked to jejunal morpholog<\/strong>y.\u201c This study investigating pituitary regulation of gonadal function in treated and untreated male patients with Celiac Disease demonstrated a derangement of pituitary regulation of gonadal function. Exaggerated responses of FSH (89%) and LH (49%) to LHRH were found in celiacs with sub-total villous atrophy and were commonly found when basal gonadotropin concentrations were normal. LH response was closely linked to jejunal morphology.<a href=\"#footnote_9_812\" id=\"identifier_19_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: III. Pituitary regulation. Clinical Endocrinology. Dec 1983;19(6):661-71.\">9<\/a><\/p>\n<p style=\"text-align: justify\">\u201c<strong>Male gonadal function in coeliac disease: 2. Sex hormones<\/strong>.\u201d This study investigating levels of plasma testosterone, dihydrotestosterone, sex-hormone binding globulin, estradiol, and luteinising hormone in men with Celiac Disease and relating these findings to jejunal morphology, fertility, semen quality, and sexual function demonstrated androgen resistance and hypothalmic-pituitary dysfunction that appear to be relatively specific to Celiac Disease and cannot be explained merely in terms of malnutrition or chronic ill-health. Endocrine disturbance may be related to sexual dysfunction in Celiac Disease, but its relationship to disordered spermatogenesis in Celiac Disease has not been clearly established.<a href=\"#footnote_3_812\" id=\"identifier_20_812\" class=\"footnote-link footnote-identifier-link\" title=\"Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: 2. Sex hormones. Gut. Feb 1983;24(2):127-35.\">3<\/a><\/p>\n<p style=\"text-align: justify\">\n<ol class=\"footnotes\"><li id=\"footnote_1_812\" class=\"footnote\">Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. <i>Int J Clin Pract<\/i>. 2006 Jul;60(7):762-9.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_3_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_2_812\" class=\"footnote\">Shortridge EF, Polzer P, Donga P, Blanchette CM, Fang Y, Burudpakdee C, Carswell B. Experiences and treatment patterns of hypogonadal men in a U.S. health system. <em>Int J Clin Pract<\/em>. 2014 Mar 28. doi: 10.1111\/ijcp.12418. <span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_2_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_3_812\" class=\"footnote\">Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: 2. Sex hormones. <em>Gut<\/em>. Feb 1983;24(2):127-35.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_4_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_9_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_20_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_4_812\" class=\"footnote\">Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: III. Pituitary regulation. Clinical Endocrinology. Dec 1983;19(6):661-71.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_5_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_5_812\" class=\"footnote\">Stazi AV, Mantovani A. Celiac disease and its endocrine and nutritional implications on male reproduction. <em>Minerva Medica<\/em>. Jun 2004;95(3):243-54.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_6_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_7_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_8_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_10_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_6_812\" class=\"footnote\">Cummins AG, Thompson FM, Butler RN, et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease.\u00a0<em>Clinical Science<\/em>. Apr 2001;100(4):379-86.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_11_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_7_812\" class=\"footnote\">Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.\u00a0<em>Journal of Gastroenterology and Hepatology<\/em>. 2003;18:479-91.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_12_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_13_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_14_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_15_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_16_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_17_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_8_812\" class=\"footnote\">Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, Mulder CJ, van Bodegraven AA. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. <i>Nutrients<\/i>. 2013 Sep 30;5(10):3975-92. doi: 10.3390\/nu5103975.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_18_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_9_812\" class=\"footnote\">Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: III. Pituitary regulation. <em>Clinical Endocrinology<\/em>. Dec 1983;19(6):661-71.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_19_812\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>What Is Unexplained Adult Male Hypogonadism? Hypogonadism in males is a distressing reproductive disorder characterized by inadequate production of male andogen hormones and\/or spermatozoa by the testes. Q: How do andogens affect reproductive health? A: Male androgen hormones control the development and maintenance of male sex organs and masculine secondary sex characteristics and are\u00a0required for &#8230;<\/p>\n","protected":false},"author":29,"featured_media":8277,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4,779,167,225,226,151,111,123,109],"tags":[101,1012,776,595,1941,57,1977,1978,1368,915,1930,1908,1918,1907],"class_list":["post-812","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-conditions-2","category-associated-disorder","category-omega-6-fatty-acids","category-male","category-testes","category-vitamin-a","category-vitamin-d","category-vitamin-e","category-zinc","tag-associated-disorders","tag-hair-loss","tag-health-conditions","tag-low-sperm-count","tag-omega-6-fatty-acids","tag-reproductive-2","tag-male","tag-testes","tag-thin-muscles","tag-unexplained-hypogonadism-in-adults","tag-vitamin-a","tag-vitamin-d","tag-vitamin-e","tag-zinc"],"_links":{"self":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/812","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/comments?post=812"}],"version-history":[{"count":24,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/812\/revisions"}],"predecessor-version":[{"id":18835,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/812\/revisions\/18835"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media\/8277"}],"wp:attachment":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media?parent=812"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/categories?post=812"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/tags?post=812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}