{"id":738,"date":"2014-11-29T19:27:08","date_gmt":"2014-11-30T00:27:08","guid":{"rendered":"http:\/\/www.mynutriguide.com\/?p=738"},"modified":"2020-07-11T10:41:37","modified_gmt":"2020-07-11T14:41:37","slug":"increased-pulmonary-permeability-2","status":"publish","type":"post","link":"https:\/\/glutenfreeworks.com\/health\/increased-pulmonary-permeability-2\/","title":{"rendered":"Pulmonary Permeability, Increased\u00a0"},"content":{"rendered":"<div id=\"attachment_8340\" style=\"width: 310px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/4IkjGdScTNvJLOc-7n1Tnw.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-8340\" class=\"size-medium wp-image-8340\" src=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/4IkjGdScTNvJLOc-7n1Tnw-300x215.png\" alt=\"Image shows \" width=\"300\" height=\"215\" srcset=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/4IkjGdScTNvJLOc-7n1Tnw-300x215.png 300w, https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/4IkjGdScTNvJLOc-7n1Tnw.png 500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-8340\" class=\"wp-caption-text\">Image Showing \u00a0Blood-Air Barrier in the Lung. <em>Courtesy quizlet.com<\/em><\/p><\/div>\n<h2>What Is Increased Pulmonary Permeability?<\/h2>\n<p style=\"text-align: justify\"><span class=\"dropcap\">I<\/span>ncreased pulmonary permeability is a mucosal defect in the lung characterized by alteration of the normally tight epithelial \u00a0blood-air barrier in the lung apparently caused by inflammation.<\/p>\n<p style=\"text-align: justify\"><strong>Q:<\/strong> What is the blood-air barrier in the lung?<\/p>\n<p style=\"text-align: justify\"><strong>A:<\/strong>\u00a0This\u00a0blood-air barrier in the lung\u00a0consists of the alveolar epithelium\u00a0(surface cells of the alveoli), the underlying capillary endothelium (surface cells of the capillaries), their basement membranes and the interstitial space between the cell layers.<\/p>\n<p style=\"text-align: justify\">Alveoli are also called &#8220;air sacs.&#8221; The exchange of oxygen breathed into air sacs from air on inspiration and carbon dioxide breathed out from capillary blood on expiration occurs between \u00a0air sacs and capillaries.<\/p>\n<p style=\"text-align: justify\">The capillary endothelium prevents proteins in blood from leaking (permeating) into the air sacs while allowing water and small molecules to pass. This is why breath has moisture in it.<\/p>\n<p style=\"text-align: justify\">Little is known about the interactions between the alveolar and the blood compartment.<a href=\"#footnote_1_738\" id=\"identifier_1_738\" class=\"footnote-link footnote-identifier-link\" title=\"Neuhaus W, Samwer F, Kunzmann S, Muellenbach RM, Wirth M, Speer CP, Roewer N, F&ouml;rster CY. Lung endothelial cells strengthen, but brain endothelial cells weaken barrier properties of a human alveolar epithelium cell culture model. Differentiation. 2012 Nov;84(4):294-304. doi: 10.1016\/j.diff.2012.08.006. Epub 2012 Sep 27.\">1<\/a><\/p>\n<h2>What Is Increased Pulmonary Permeability In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p><!--more--><\/p>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between pulmonary permeability and celiac disease.<\/strong> Increased pulmonary permeability is a pulmonary complication in celiac disease.\u00a0Increased pulmonary permeability is a recognized subclinical pulmonary abnormality of celiac disease characterized by abnormal clearance of gases.\u00a0There is a common mucosal defect in lung and small intestine in celiac disease, allowing increased permeability or leakage.<a href=\"#footnote_2_738\" id=\"identifier_2_738\" class=\"footnote-link footnote-identifier-link\" title=\"Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in coeliac disease and inflammatory bowel disease. Digestion. 1989;42(2):98-103.\">2<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Relationship between pulmonary permeability and mucosal changes in the air sacs.\u00a0<\/strong>Increased pulmonary permeability is marked by mucosal changes in the air sacs without loss of airflow because there is no narrowing of passageways.<a href=\"#footnote_3_738\" id=\"identifier_3_738\" class=\"footnote-link footnote-identifier-link\" title=\"Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in coeliac disease and inflammatory bowel disease.&nbsp;Digestion. 1989;42(2):98-103.\">3<\/a><\/li>\n<\/ul>\n<h2>How Prevalent is Increased Pulmonary Permeability In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p style=\"text-align: justify\">Increased pulmonary permeability has increased frequency in patients with celiac disease.<a href=\"#footnote_2_738\" id=\"identifier_4_738\" class=\"footnote-link footnote-identifier-link\" title=\"Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in coeliac disease and inflammatory bowel disease. Digestion. 1989;42(2):98-103.\">2<\/a><\/p>\n<h2>What Are The Symptoms Of Increased Pulmonary Permeability?<\/h2>\n<ul class=\"cp_bullet red\">\n<li>Chronic cough.<\/li>\n<\/ul>\n<h2>How Does Increased Pulmonary Permeability Develop In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\">Increased pulmonary permeability results from a mucosal defect in the lung in celiac disease.<a href=\"#footnote_4_738\" id=\"identifier_5_738\" class=\"footnote-link footnote-identifier-link\" title=\"Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in celiac disease and inflammatory bowel disease. Digestion. 1989;42(2):98-103.\">4<\/a> apparently due to proinflammatory cytokines causing inflammation.<a href=\"#footnote_5_738\" id=\"identifier_6_738\" class=\"footnote-link footnote-identifier-link\" title=\"Hermanns MI, Unger RE, Kehe K, Peters K, Kirkpatrick CJ. Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro. Lab Invest. 2004 Jun;84(6):736-52.\">5<\/a><\/li>\n<\/ul>\n<h2 style=\"text-align: justify\">Does Increased Pulmonary Permeability Respond To Gluten-Free Diet?<\/h2>\n<p style=\"text-align: justify\">In a case report described by\u00a0Hayat et al. of an 8-year-old girl presenting with chronic cough as the only presenting feature of underlying celiac disease, the cough rapidly resolved after the commencement of a strict gluten exclusion diet.<\/p>\n<h2 style=\"text-align: justify\">6 Steps To Improve Increased Pulmonary Permeability\u00a0In Celiac Disease and\/or Gluten Sensitivity:<\/h2>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>1<\/strong><\/span><\/span><strong><span style=\"color: #800000\">Remove the Trigger. Maintain a Strict, Nutritious Gluten Free Diet:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<b>Treatment<\/b>. This condition responds to the complete elimination of gluten, which is the required treatment that improves both \u00a0and gut health.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Gut health is the foundation to restore ALL health. Restored health will enable you to maintain a strict gluten free diet, just as other life tasks will be easier.<\/li>\n<li>A strict gluten free diet means removing 100% of wheat, barley, rye and oats from the diet.<\/li>\n<li>Cutting out bread and other obvious sources of gluten is not good enough for recovery. Even 1\/8th teaspoon of flour or bread crumb is enough to sustain the inflammation that is damaging your small intestine, causing increased permeability (leaky gut) and allowing undigested gluten to enter your body where it can damage structures and function, and instigate immune inflammatory responses.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Correct Your Individual Nutritional Needs.<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eat foods that can replenish missing nutrients. Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<li>Take nutritional supplements as needed.\u00a0Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Recovery<\/strong>. You should begin to feel better within a week and notice more energy as inflammation subsides and the \u00a0absorbing cells that make up the surface lining of your small intestine are better able to function.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Intestinal lining cells are replaced every 5 days. The healing process is like sunburn where the damaged surface layer of skin sloughs off and is replaced with new normal cells.<\/li>\n<li>Leaky gut normally resolves in two month after starting a gluten free diet and brings about a big improvement in health. Improvement in intestinal permeability precedes morphometric recovery (cell appearance and structure) of the small intestine in celiac disease.<a href=\"#footnote_6_738\" id=\"identifier_7_738\" class=\"footnote-link footnote-identifier-link\" title=\"Cummins AG, Thompson FM, Butler RN, et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease.&nbsp;Clinical Science. Apr 2001;100(4):379-86.\">6<\/a><\/li>\n<li>The intestinal lining may take up to a year to heal.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>2<\/strong><\/span><\/span><strong><span style=\"color: #800000\">\u00a0Reduce Inflammation. Foods to Eat and Foods Not to Eat:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\">Because gluten is inflammatory, eliminate OTHER inflammatory foods from your diet to reduce an additive effect to gluten. At the same time, try to eat foods that reduce inflammation (anti-inflammatory).<\/p>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Major Inflammatory Food Types That Reduce Healing<\/strong>:<\/p>\n<ul class=\"cp_bullet red\" style=\"text-align: justify\">\n<li><strong>Damaging Foods<\/strong>. In susceptible persons, includes corn, dairy (cow), and soy. Lactose, the sugar in any animal milk disrupts intestinal permeability causing leaky gut.<a href=\"#footnote_7_738\" id=\"identifier_8_738\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Allergenic Foods<\/strong>. Includes foods that trigger the immune sytem to produce IgE antibodies. Allergy testing is the usual way to discover these offending foods.<\/li>\n<li><strong>Shelf Stable Processed Foods.\u00a0<\/strong>Includes any that contain additives and preservatives. Look for them on the nutrition label of the box or package. Additives and preservatives also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_7_738\" id=\"identifier_9_738\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Fats.<\/strong>\u00a0Limit deep fried foods, trans-fats, saturated fats (animal fat\/butter), and EXCESSIVE omega-6 fatty acid oils like corn oil. Rancid fats, sodium caprate (a medium chain fat), and sucrose monester fatty acid (a food grade surfactant) induce significant disruption of the intestinal barrier that causes leaky gut.<a href=\"#footnote_7_738\" id=\"identifier_10_738\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a>.<\/li>\n<li><strong>Excessive Refined White Flours\u00a0<\/strong>(bran layer removed)<strong>.\u00a0<\/strong>Includes\u00a0products made from them such as cookies, bread, cakes, pies.\u00a0Bran contains the vitamins and minerals that metabolize grains and slows the otherwise rapid entry of sugar from their digestion into the bloodstream.\u00a0Also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_7_738\" id=\"identifier_11_738\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Refined Sugars.\u00a0<\/strong>\u00a0Includes white sugar, corn fructose and high fructose corn syrup.<\/li>\n<li><strong>Certain Spices<\/strong>. Includes paprika and cayenne pepper which disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_7_738\" id=\"identifier_12_738\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Alcohol and Caffeine<\/strong>. Disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_7_738\" id=\"identifier_13_738\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">7<\/a><\/li>\n<li><strong>Cocoa and Black\u00a0Tea<\/strong>\u00a0increase blood sugar.<\/li>\n<li><strong>Rosemary.<\/strong>\u00a0Increases blood sugar levels and should not be used by persons with insulin resistance or diabetes. \n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Important Anti-Inflammatory Food Types to Promote Health<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li><strong>Fruits<\/strong>.\u00a0Contain ample amounts of vitamins, minerals and phytochemicals which are\u00a0naturally occuring components in plants that detoxify toxins, carcinogens (reducing the risk by 50%) and mutagens.<\/li>\n<li><strong>Non-Starchy Vegetables.<\/strong>\u00a0Support intestinal integrity and provide ample amounts of vitamins, minerals and phytochemicals. Includes green leafy vegetables such as lettuce and kale, also onion, broccoli, garlic, and others.<\/li>\n<li><strong>High Quality Complex Carbohydrates<\/strong>. Provide vitamins, minerals, and fiber while boosting serotonin levels to help you relax and feel calm. Includes whole grains, legumes, and root vegetables such as carrots, parsnips, sweet potatoes, turnips, red beets, and others.<\/li>\n<li><strong>Antioxidants<\/strong>. Protect the body from inflammatory oxidant molecules that continually occur and\u00a0help us handle stress and reduce irritability. Includes vitamin C-containing foods such as lemon, grapefruit, apricot, Brussels sprouts and strawberries, and others. Also, includes vitamin E-containing foods such as\u00a0nuts, seeds, avocado, olive oil, and others. Cocoa is good, too.<\/li>\n<li><strong>Omega-3 Fatty Acids<\/strong>. Balance opposing omega-6 fatty acids and bad fats. Fish sources includes tuna, salmon, cod, and others. Plants sources include flax, chia seeds, canola oil, and others.<\/li>\n<li><strong>Probiotics.\u00a0<\/strong>Supply normal microbes needed for colon health and health of the body such as these fermented foods: yogurt, kefir, and unpasteurized apple cider vinegar.<\/li>\n<li><strong>Prebiotics\/ High Fiber Foods<\/strong>. \u00a0Food with fiber keeps our population of colonic microbes healthy.<\/li>\n<li><strong>Protective Herbs and Spices<\/strong>. \u00a0See below #6 below for examples.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">3<\/span>\u00a0Information Sheet You Can Take to Your Doctor or Other Health Professional:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\">Click here.<\/p>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><span style=\"color: #800000\"><strong><em><span class=\"dropcap\">4<\/span>\u00a0Manage Your Medications\u00a0Safely<\/em>:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">Certain medications may cause increased pulmonary permeability which would aggravate the in celiac disease. Ask your doctor or pharmacist about this possible adverse effect if you are taking medications on a regular basis and have a chronic cough.\u00a0<strong>Do not stop prescribed medications without supervision.<\/strong><\/p>\n<p style=\"text-align: justify\">\u00a0\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">5<\/span>Nutritional Supplements To Help Correct Deficiencies:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">The type and quantity of nutritional supplements that may be needed depend on which nutrients are deficient.<\/p>\n<ul class=\"cp_bullet orange\" style=\"text-align: justify\">\n<li>Multivitamin\/mineral combination that provides 100% once a day is useful to improve overall nutrient levels. This is a safe dose, but always check with your doctor to avoid interactions with medications.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Storage Note<\/strong>:\u00a0<em>Store container tightly sealed, away from heat, moisture and direct light to avoid loss of potency. That is, in a safe kitchen cabinet &#8211; not in the bathroom or on the kitchen table<\/em>.\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><span style=\"color: #800000\"><em><strong><span class=\"dropcap\">6<\/span>Manage Natural Remedies:\u00a0<\/strong><\/em><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Hydration<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eight glasses of water are recommended per day unless there is a contraindication such as kidney or heart disease. The Institute of Medicine recommends approximately 2.7 liters (91 ounces) of total water, from all beverages and foods, each day for women and 3.7 liters (125 ounces) daily of total water for men.<\/li>\n<li>If you are thirsty, drink water. Add fresh, squeezed lemon to water. Lemon is anti-inflammatory, alkalizing and provides vitamin C.<\/li>\n<li>Hydration Test: Urine should be pale yellow. Fingertips should be plump, without pruning but this may not be reliable when fingers are swollen with edema. Lips should be plump, without puckering. The feeling of thirst can be unreliable.<\/li>\n<li>What is wrong with soda, coffee, tea, and alcohol? These drinks are dehydrating, increase acid, and deplete nutrients.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Carminatives.\u00a0<\/strong>The following \u00a0anti-inflammatory\u00a0plant sources called carminitives help heal the digestive tract. They also tone the digestive muscles which improves peristalsis, thus aiding in the expulsion of gas from the stomach and intestine to relieve digestive colic and gastric discomfort.<\/p>\n<p style=\"text-align: justify\"><strong>Carminative Food Remedies<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Raspberry.<\/li>\n<li>Carrot is also a cleansing digestive tonic.<\/li>\n<li>Grape is also bile stimulating and a cleansing remedy for sluggish digestion and laxative.<\/li>\n<li>Redbeets also stimulate and improve digestion and are easily digested.<\/li>\n<li>Cabbage also stimulates and improves digestion and is also a liver decongestant.<\/li>\n<li>Lettuce also stimulates and improves digestion and is also an alterative, meaning it improves the function of organs involved with the digestion and excretion of waste products to bring about a gradual change.<\/li>\n<li>Potatoes are antispasmodic (due to atropine like properties) and a liver remedy.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Herb Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Sage is also a digestive, astringent, bile stimulant and energy tonic that heals the mucosa. \u00a0Drink as tea or use in cooking.<\/li>\n<li>Chamomile, lemon balm, and fennel, (as a tea) also help relieve nervous tension.<\/li>\n<li>Parsley also relieves indigestion.<\/li>\n<li>Rosemary as a tea and in cooking also is a nervous system tonic for stress and fatigue, bile stimulant, and can relieve headaches and indigestion. However, because it increases blood sugar levels, it should not be used by persons with insulin resistance or diabete.<\/li>\n<li>Thyme is also soothing remedy useful for stimulating digestion of rich, fatty foods.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Spice Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Cloves are also antispasmodic.<\/li>\n<li>Nutmeg is also useful for indigestion.<\/li>\n<li>Ginger.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Exercise Helps<\/strong>:<\/p>\n<p style=\"text-align: justify\">Exercise improves circulation and rids the body of toxins.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Walking is aerobic exercise that reconditions the whole body to improve stamina.\u00a0Read more about<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">\u00a0Exercise and Fitness<\/a>.<\/li>\n<li>Weight training builds muscle.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<li>Stretching improves flexibilty.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Note<\/strong>: Exercise is important, but the amount and type of exercise undertaken depends on your health. Your first priority is to heal. \n\t\t\t<\/div><\/div>\n<h2 style=\"text-align: justify\">What Do Medical Research Studies Tell About Increased Pulmonary Permeability In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<h4><strong>RESEARCH STUDY SUMMARIES<\/strong><\/h4>\n<p style=\"text-align: justify\"><strong>\u201cPulmonary permeability in coeliac disease and inflammatory bowel disease.\u201d<\/strong>\u00a0This study investigating lung function in 25 patients with inflammatory bowel disease (IBD) and 18 patients with celiac disease on a gluten free diet compared to 20 normal patients, all without respiratory symptoms, demonstrated that airflow in patients on a gluten free diet is not significantly different from controls, but there is an increase in pulmonary permeability.<\/p>\n<p style=\"text-align: justify\">By contrast patients with IBD had decreased airflow and no change in permeability. These findings suggest that the mechanisms of lung disease in celiac disease differs from that in IBD and supports the hypothesis of a common mucosal defect in lung and small intestine in celiac disease, allowing increased permeability.<a href=\"#footnote_2_738\" id=\"identifier_14_738\" class=\"footnote-link footnote-identifier-link\" title=\"Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in coeliac disease and inflammatory bowel disease. Digestion. 1989;42(2):98-103.\">2<\/a><\/p>\n<h4 style=\"text-align: justify\"><strong>CASE REPORT SUMMARIES<\/strong><\/h4>\n<p style=\"text-align: justify\">&#8220;<strong>Coeliac disease presenting as chronic cough in an 8-year-old child<\/strong>.&#8221; An 8-year-old girl presented to the outpatient department with an 18 month history of persistent non-productive cough. Her father reported that the cough began in the summer months and had progressively worsened. There was no association with wheeze, chest tightness, nor shortness of breath on exertion. Similarly, there was no association with posture and the cough was not heard by the parents at night.<\/p>\n<p style=\"text-align: justify\">She was born at term following a healthy pregnancy to non-smoking parents. She breast fed up to 4 months after which she was successfully weaned by 6 months. There were no concerns with her growth and development. Her height and weight continued to lie on the 9th centile. Over the years she had received steroid treatment for frequent bouts of viral croup, the last being 12 months previously. Mild asthma suffered by her father was the only significant family history.<\/p>\n<p style=\"text-align: justify\">Prior to her attendance at pediatric clinic she had a flexible bronchoscopy in the ear, nose and throat department which was reported as normal. Physical examination was unremarkable. Normal investigations included full blood count, renal and liver function tests, bone profile, erythrocyte sedimentation rate and thyroid function tests. Immunological testing of radioallergosorbent test against house dust mite, cat, grass and tree pollen was negative. A chest radiograph and sweat test were normal.<\/p>\n<p style=\"text-align: justify\">However, an antitissue transglutaminase (tTG) IgA antibody titre was positive at 21 U\/ml (0\u201310). On direct questioning she had no gastrointestinal symptoms, nor personal or family history of auto-immune conditions. However, in view of the elevated tTG level, endoscopic duodenal biopsies were obtained\u00a0showing subtotal villous atrophy with crypt regenerative hyperplasia and focal intraepithelial lymphocytosis consistent with celiac disease, Marsh stage 3b.<\/p>\n<p style=\"text-align: justify\">A diagnosis of celiac disease\u00a0was made. A gluten exclusion diet was commenced and on review 6 weeks later her symptoms had entirely resolved. Subsequent serological testing of the immediate family led to confirmation of asymptomatic celiac disease\u00a0in the mother of the patient.<a href=\"#footnote_8_738\" id=\"identifier_15_738\" class=\"footnote-link footnote-identifier-link\" title=\"Hayat S, Pitchaikani PK, Williams N, Cosgrove M. Coeliac disease presenting as chronic cough in an 8-year-old child. BMJ Case Rep. 2011 Dec 5;2011. pii: bcr1020115064. doi: 10.1136\/bcr.10.2011.5064.\">8<\/a><\/p>\n<ol class=\"footnotes\"><li id=\"footnote_1_738\" class=\"footnote\">Neuhaus W, Samwer F, Kunzmann S, Muellenbach RM, Wirth M, Speer CP, Roewer N, F\u00f6rster CY. Lung endothelial cells strengthen, but brain endothelial cells weaken barrier properties of a human alveolar epithelium cell culture model. <em style=\"line-height: 1.5em\">Differentiation<\/em>. 2012 Nov;84(4):294-304. doi: 10.1016\/j.diff.2012.08.006. Epub 2012 Sep 27.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_2_738\" class=\"footnote\">Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in coeliac disease and inflammatory bowel disease. <em>Digestion<\/em>. 1989;42(2):98-103.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_2_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_4_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_14_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_3_738\" class=\"footnote\">Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in coeliac disease and inflammatory bowel disease.\u00a0<em>Digestion<\/em>. 1989;42(2):98-103.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_3_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_4_738\" class=\"footnote\">Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in celiac disease and inflammatory bowel disease. Digestion. 1989;42(2):98-103.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_5_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_5_738\" class=\"footnote\">Hermanns MI, Unger RE, Kehe K, Peters K, Kirkpatrick CJ. Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro. <em>Lab Invest.<\/em> 2004 Jun;84(6):736-52.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_6_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_6_738\" class=\"footnote\">Cummins AG, Thompson FM, Butler RN, et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease.\u00a0<em>Clinical Science<\/em>. Apr 2001;100(4):379-86.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_7_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_7_738\" class=\"footnote\">Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.\u00a0<em>Journal of Gastroenterology and Hepatology<\/em>. 2003;18:479-91.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_8_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_9_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_10_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_11_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_12_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_13_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_8_738\" class=\"footnote\">Hayat S, Pitchaikani PK, Williams N, Cosgrove M. Coeliac disease presenting as chronic cough in an 8-year-old child. <em>BMJ Case Rep<\/em>. 2011 Dec 5;2011. pii: bcr1020115064. doi: 10.1136\/bcr.10.2011.5064.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_15_738\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>What Is Increased Pulmonary Permeability? Increased pulmonary permeability is a mucosal defect in the lung characterized by alteration of the normally tight epithelial \u00a0blood-air barrier in the lung apparently caused by inflammation. Q: What is the blood-air barrier in the lung? A:\u00a0This\u00a0blood-air barrier in the lung\u00a0consists of the alveolar epithelium\u00a0(surface cells of the alveoli), the &#8230;<\/p>\n","protected":false},"author":29,"featured_media":8340,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4,783,209,70],"tags":[116,776,584,619,1964,1897],"class_list":["post-738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-conditions-2","category-complications-health-conditions-2","category-lungs","category-pulmonary-2","tag-complications","tag-health-conditions","tag-increased-pulmonary-permeability","tag-inflammation","tag-lungs","tag-pulmonary-2"],"_links":{"self":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/comments?post=738"}],"version-history":[{"count":14,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/738\/revisions"}],"predecessor-version":[{"id":18815,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/738\/revisions\/18815"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media\/8340"}],"wp:attachment":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media?parent=738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/categories?post=738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/tags?post=738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}