{"id":724,"date":"2014-12-21T19:23:23","date_gmt":"2014-12-22T00:23:23","guid":{"rendered":"http:\/\/www.mynutriguide.com\/?p=724"},"modified":"2020-07-11T10:51:39","modified_gmt":"2020-07-11T14:51:39","slug":"schizophrenic-symptoms-2","status":"publish","type":"post","link":"https:\/\/glutenfreeworks.com\/health\/schizophrenic-symptoms-2\/","title":{"rendered":"Schizophrenia"},"content":{"rendered":"<div id=\"attachment_3373\" style=\"width: 234px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/Schizophrenia_PET_scan-wikimedia.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-3373\" class=\"size-full wp-image-3373\" src=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/Schizophrenia_PET_scan-wikimedia.jpg\" alt=\"schizophrenia gluten\" width=\"224\" height=\"248\" \/><\/a><p id=\"caption-attachment-3373\" class=\"wp-caption-text\">PET scan showing schizophrenia. <em>Courtesy Wikimedia.<\/em><\/p><\/div>\n<h2>What Is Schizophrenia?<\/h2>\n<p style=\"text-align: justify\"><span class=\"dropcap\">S<\/span>chizophrenia is a thought disorder characterized by psychotic symptoms and inappropriate and bizarre behavior.<\/p>\n<p style=\"text-align: justify\">Schizophrenia involves dysfunction in any of these areas:<\/p>\n<ul class=\"cp_bullet black\">\n<ul>\n<ul>\n<ul>\n<ul>\n<li style=\"text-align: justify\">Cognition which are thinking skills that include intellect, language, mathematical ability, memory, perception, reasoning, judgment, learning, and imagination.<\/li>\n<li style=\"text-align: justify\">Interpersonal relationships.<\/li>\n<li style=\"text-align: justify\">Ability to work or attend education.<\/li>\n<li style=\"text-align: justify\">Ability to take care of physical and financial needs.<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<\/ul>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Q<\/strong>: What are psychotic symptoms?<\/p>\n<p style=\"text-align: justify\"><strong>A<\/strong>: In psychosis the symptoms vary but include loss of contact with reality shown by hallucinations, delusions, disorganized speech, and disorientation. Some may be depressed or manic. Some may be withdrawn and mute while others may become violent if frustrated or thwarted.<\/p>\n<p style=\"text-align: justify\">In hallucinations, affected persons see what is not real such as a burgler in the process of robbing them but which is not really happening or hear voices that are not real.<\/p>\n<p style=\"text-align: justify\">In delusions, affected persons may express strange ideas, claim to read minds or that they are a famous person living or dead.<\/p>\n<p style=\"text-align: justify\">Early-onset schizophrenia with onset before age 18\u00a0is defined by the same diagnostic criteria as in adults because it is continuous with adult schizophrenia. The onset before age 12 years comprises less than 1% of adult cases, and onset from age 12\u201318 years constitutes about 12\u201333% of all adult cases of schizophrenia.<a href=\"#footnote_1_724\" id=\"identifier_1_724\" class=\"footnote-link footnote-identifier-link\" title=\"Pagsberg AK, Tarp S, Glintborg D, Stenstr&oslash;m AD, Fink-Jensen A, Correll CU, Christensen R. Antipsychotic treatment for children and adolescents with schizophrenia spectrum disorders: protocol for a network meta-analysis of randomised trials. BMJ Open. 2014 Oct 10;4(10):e005708. doi: 10.1136\/bmjopen-2014-005708.\">1<\/a><\/p>\n<h2>What Is Schizophrenia In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p><!--more--><\/p>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between schizophrenia and celiac disease.<\/strong> Schizophrenia is an associated psychiatric disorder of celiac disease\u00a0with a robust relationship.<a href=\"#footnote_2_724\" id=\"identifier_2_724\" class=\"footnote-link footnote-identifier-link\" title=\"Jessica R. Jackson, William W. Eaton, Nicola G. Cascella, Alessio Fasano, and Deanna L. Kelly Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity. Psychiatr Q. Mar 2012; 83(1): 91&ndash;102. doi: &nbsp;10.1007\/s11126-011-9186-y\">2<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Relationship between schizophrenia and genes.\u00a0<\/strong>Both schizophrenia and celiac disease involve a genetic component. A\u00a0study investigating increased immune sensitivity to gluten in schizophrenia found that individuals with recent-onset psychosis and with multi-episode schizophrenia who have increased antibodies to gliadin may share some immunologic features of celiac disease, but their immune response to gliadin differs from that of celiac disease.<\/li>\n<li style=\"text-align: justify\"><strong>Relationship between schizophrenia and antibodies.\u00a0<\/strong>Persons with schizophrenia have higher than expected titers of antibodies related to celiac disease and gluten sensitivity.<a href=\"#footnote_3_724\" id=\"identifier_3_724\" class=\"footnote-link footnote-identifier-link\" title=\"Cascella NG, Kryszak D, Bhatti B, Gregory P, Kelly DL, Mc Evoy JP, Fasano A, Eaton WW. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull. 2011 Jan;37(1):94-100. doi: 10.1093\/schbul\/sbp055.\">3<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Relationship between schizophrenia and gluten sensitivity.\u00a0<\/strong>A meta-analysis of 12 original articles show that not all serum biomarkers of gluten sensitivity are elevated in patients with schizophrenia. However, the specific immune response to gluten in this population differs from that found in patients with celiac disease. The following 5 biomarkers (antibodies) of gluten sensitivity were found to be significantly elevated in patients with non-affective psychoses compared to controls: Anti-Gliadin IgG, Anti-Gliadin IgA, Anti-TTG2 IgA, Anti-Gliadin (unspecified isotype), and Anti-Wheat.\n<p style=\"text-align: justify\">Four biomarkers for gluten sensitivity, Anti-EMA IgA, Anti-TTG2 IgG, Anti-DGP IgG, and Anti-Gluten, were not found to be associated with schizophrenia.<a href=\"#footnote_4_724\" id=\"identifier_4_724\" class=\"footnote-link footnote-identifier-link\" title=\"Lachance LR, McKenzie K. Biomarkers of gluten sensitivity in patients with non-affective psychosis: a meta-analysis. Schizophr Res. 2014 Feb;152(2-3):521-7. doi: 10.1016\/j.schres.2013.12.001.\">4<\/a><\/p>\n<\/li>\n<li style=\"text-align: justify\"><strong>Relationship between schizophrenia and inheritance.\u00a0<\/strong>The conditional test looking at the combined effect of the CLDN5 gene, involved in forming permeability barriers, and the DQB1 genetic marker associated with celiac disease demonstrated these two genes possibly work together in conferring a susceptibility to schizophrenia.<a href=\"#footnote_5_724\" id=\"identifier_5_724\" class=\"footnote-link footnote-identifier-link\" title=\"Wei J, Hemmings GP. Gene, gut and schizophrenia: the meeting point for the gene-environment interaction in developing schizophrenia. Medical Hypotheses. 2005;64(3):547-52.\">5<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Relationship between schizophrenia and\u00a0<\/strong>Hypoperfusion (low blood flow) of the left frontal brain area without structural cerebral abnormalities was demonstrated in a patient with schizophrenia, and the dysfunction disappeared after gluten free diet.<a href=\"#footnote_6_724\" id=\"identifier_6_724\" class=\"footnote-link footnote-identifier-link\" title=\"De Santis A, Addolarato G, Romito A, et al. Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet.&nbsp;Journal of Internal Medicine. Nov 1997;242(5):421-3.\">6<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Relationship between schizophrenia and wheat exomorphines.\u00a0<\/strong>Wheat gluten hydrolysates, called exomorphines, exhibit a high opioid-like activity in isolated peptides. While some peptides showed no activity, 0.5 mg of the most active peptides were equivalent to 1 nM of morphine in the binding assay and were derived from the gliadin fraction of gluten.<a href=\"#footnote_7_724\" id=\"identifier_7_724\" class=\"footnote-link footnote-identifier-link\" title=\"Huebner FR, Lieberman KW, Rubino RP, Wall JS. Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates. Peptides. Nov-Dec 1984;5(6):1139-47.\">7<\/a><\/li>\n<\/ul>\n<h2>How Prevalent Is Schizophrenia In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<ul class=\"cp_bullet black\">\n<li style=\"text-align: justify\">Gluten sensitivity is common in schizophrenia.<a href=\"#footnote_8_724\" id=\"identifier_8_724\" class=\"footnote-link footnote-identifier-link\" title=\"Potocki P, Hozyasz K. Psychiatric symptoms and coeliac disease. Psychiatria Polska. Jul-Aug 2002;36(4):567-78.\">8<\/a><\/li>\n<li style=\"text-align: justify\">Psychotic symptoms often occur in adult celiac disease.<a href=\"#footnote_9_724\" id=\"identifier_9_724\" class=\"footnote-link footnote-identifier-link\" title=\"Wei J, Hemmings GP. Gene, gut and schizophrenia: the meeting point for the gene-environment interaction in developing schizophrenia. Medical Hypotheses. 2005;64(3):547-52.\">9<\/a><\/li>\n<li style=\"text-align: justify\">A prevalence study among schizophrenia patients showed that 23.1% had moderate to high levels of IgA-AGA compared with 3.1% of the comparison group. \u00a0Moderate to high levels of tTG antibodies were present in 5.4% of schizophrenia patients vs 0.80% of the comparison group.<a href=\"#footnote_3_724\" id=\"identifier_10_724\" class=\"footnote-link footnote-identifier-link\" title=\"Cascella NG, Kryszak D, Bhatti B, Gregory P, Kelly DL, Mc Evoy JP, Fasano A, Eaton WW. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull. 2011 Jan;37(1):94-100. doi: 10.1093\/schbul\/sbp055.\">3<\/a><\/li>\n<\/ul>\n<h2>What Are The Symptoms Of Schizophrenia?<\/h2>\n<p style=\"text-align: justify\">Schizophrenia is marked by the following symptoms:<\/p>\n<ul class=\"cp_bullet red\">\n<li>Confusion.<\/li>\n<li>Delusions.<\/li>\n<li>Hallucinations.<\/li>\n<li>Disorganized speech and behavior.<\/li>\n<li>Lack of insight.<\/li>\n<li>Flat affect.<\/li>\n<li>Social withdrawal.<\/li>\n<li>Absence of volition (desire to act).<\/li>\n<\/ul>\n<h2>How Does Schizophrenia In Celiac Disease and\/or Gluten Sensitivity Develop?<\/h2>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\">Gluten exerts a primary schizophrenia-promoting effect evidenced by improvement with gluten withdrawal and exacerbation with reinstatement.<a href=\"#footnote_10_724\" id=\"identifier_11_724\" class=\"footnote-link footnote-identifier-link\" title=\"Singh MM, Kay SR. Wheat gluten as a pathogenic factor in schizophrenia. Science. Jan 30, 1976;191(4225):401-2.\">10<\/a>,<a href=\"#footnote_11_724\" id=\"identifier_12_724\" class=\"footnote-link footnote-identifier-link\" title=\"Rudin DO. The choroid plexus and system disease in mental illness. III. The exogenous peptide hypothesis of mental illness.&nbsp;Biological Psychiatry. May 1981;16(5):489-512.\">11<\/a><\/li>\n<li style=\"text-align: justify\">Schizophrenia in celiac disease results from exposure to gluten through increased intestinal permeability of the small intestine and malnutrition in celiac disease involving deficiencies of vitamin C, vitamin B12 (causing paranoia in particular),\u00a0magnesium, and EPA (omega-3 fatty acid). Beta-lactoglobulin and casein from cow&#8217;s milk are also involved in producing symptoms.<a href=\"#footnote_12_724\" id=\"identifier_13_724\" class=\"footnote-link footnote-identifier-link\" title=\"Reichelt KL, Landmark J. Specific IgA antibody increases in schizophrenia.&nbsp;Biological psychiatry. Mar 15, 1995;37(6):410-3.\">12<\/a><\/li>\n<li style=\"text-align: justify\">Gluten appears to exert an innate immune response.<a href=\"#footnote_13_724\" id=\"identifier_14_724\" class=\"footnote-link footnote-identifier-link\" title=\"Cascella NG, Santora D, Gregory P, Kelly DL, Fasano A, Eaton WW. Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients. Schizophr Bull. 2013 Jul;39(4):867-71. doi: 10.1093\/schbul\/sbs064.\">13<\/a> An innate response involves inflamation caused by gluten but does not involve the production of celiac antobodies.<\/li>\n<\/ul>\n<h2>Does Schizophrenic Symptoms Respond To Gluten-Free Diet?<\/h2>\n<p style=\"text-align: justify\">Yes. Schizophrenia improves and may resolve on gluten free diet.<a href=\"#footnote_14_724\" id=\"identifier_15_724\" class=\"footnote-link footnote-identifier-link\" title=\"Serratrice J, Disdier P, Kaladjian A, et al. Psychosis revealing a silent celiac disease in a young woman with trisomy 21.&nbsp;La Presse Medicale. Oct 12, 2002;31(33):1551-3.\">14<\/a>,<a href=\"#footnote_9_724\" id=\"identifier_16_724\" class=\"footnote-link footnote-identifier-link\" title=\"Wei J, Hemmings GP. Gene, gut and schizophrenia: the meeting point for the gene-environment interaction in developing schizophrenia. Medical Hypotheses. 2005;64(3):547-52.\">9<\/a>,<a href=\"#footnote_15_724\" id=\"identifier_17_724\" class=\"footnote-link footnote-identifier-link\" title=\"Singh MM, Kay SR. Wheat gluten as a pathogenic factor in schizophrenia. Science. Jan 30, 1976;191(4225):401-2.\">15<\/a><\/p>\n<h2>6 Steps To Improve Schizophrenia In Celiac Disease and\/or Gluten Sensitivity:<\/h2>\n<ul class=\"cp_check green\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>1<\/strong><\/span><\/span><strong><span style=\"color: #800000\">Remove the Trigger. Maintain a Strict, Nutritious Gluten Free Diet:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<b>Treatment<\/b>. This condition responds to the complete elimination of gluten, which is the required treatment that improves both schizophrenia and gut health.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Gut health is the foundation to restore ALL health. Restored health will enable you to maintain a strict gluten free diet, just as other life tasks will be easier.<\/li>\n<li>A strict gluten free diet means removing 100% of wheat, barley, rye and oats from the diet.<\/li>\n<li>Cutting out bread and other obvious sources of gluten is not good enough for recovery. Even 1\/8th teaspoon of flour or bread crumb is enough to sustain the inflammation that is damaging your small intestine, causing increased permeability (leaky gut) and allowing undigested gluten to enter your body where it can damage structures and function, and instigate immune inflammatory responses.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Correct Your Individual Nutritional Needs.<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eat foods that can replenish missing nutrients. Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<li>Take nutritional supplements as needed.\u00a0Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Recovery<\/strong>. You should begin to feel better within a week and notice more energy as inflammation subsides and the \u00a0absorbing cells that make up the surface lining of your small intestine are better able to function.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Intestinal lining cells are replaced every 5 days. The healing process is like sunburn where the damaged surface layer of skin sloughs off and is replaced with new normal cells.<\/li>\n<li>Leaky gut normally resolves in two month after starting a gluten free diet and brings about a big improvement in health. Improvement in intestinal permeability precedes morphometric recovery (cell appearance and structure) of the small intestine in celiac disease.<a href=\"#footnote_16_724\" id=\"identifier_18_724\" class=\"footnote-link footnote-identifier-link\" title=\"Cummins AG, Thompson FM, Butler RN, et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease.&nbsp;Clinical Science. Apr 2001;100(4):379-86.\">16<\/a><\/li>\n<li>The intestinal lining may take up to a year to heal.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>2<\/strong><\/span><\/span><strong><span style=\"color: #800000\">\u00a0Reduce Inflammation. Foods to Eat and Foods Not to Eat:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\">Because gluten is inflammatory, eliminate OTHER inflammatory foods from your diet to reduce an additive effect to gluten. At the same time, try to eat foods that reduce inflammation (anti-inflammatory).<\/p>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Major Inflammatory Food Types That Reduce Healing<\/strong>:<\/p>\n<ul class=\"cp_bullet red\" style=\"text-align: justify\">\n<li><strong>Damaging Foods<\/strong>. In susceptible persons, includes corn, dairy (cow), and soy. Lactose, the sugar in any animal milk disrupts intestinal permeability causing leaky gut.<a href=\"#footnote_17_724\" id=\"identifier_19_724\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">17<\/a><\/li>\n<li><strong>Allergenic Foods<\/strong>. Includes foods that trigger the immune sytem to produce IgE antibodies. Allergy testing is the usual way to discover these offending foods.<\/li>\n<li><strong>Shelf Stable Processed Foods.\u00a0<\/strong>Includes any that contain additives and preservatives. Look for them on the nutrition label of the box or package. Additives and preservatives also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_17_724\" id=\"identifier_20_724\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">17<\/a><\/li>\n<li><strong>Fats.<\/strong>\u00a0Limit deep fried foods, trans-fats, saturated fats (animal fat\/butter), and EXCESSIVE omega-6 fatty acid oils like corn oil. Rancid fats, sodium caprate (a medium chain fat), and sucrose monester fatty acid (a food grade surfactant) induce significant disruption of the intestinal barrier that causes leaky gut.<a href=\"#footnote_17_724\" id=\"identifier_21_724\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">17<\/a>.<\/li>\n<li><strong>Excessive Refined White Flours\u00a0<\/strong>(bran layer removed)<strong>.\u00a0<\/strong>Includes\u00a0products made from them such as cookies, bread, cakes, pies.\u00a0Bran contains the vitamins and minerals that metabolize grains and slows the otherwise rapid entry of sugar from their digestion into the bloodstream.\u00a0Also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_17_724\" id=\"identifier_22_724\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">17<\/a><\/li>\n<li><strong>Refined Sugars.\u00a0<\/strong>\u00a0Includes white sugar, corn fructose and high fructose corn syrup.<\/li>\n<li><strong>Certain Spices<\/strong>. Includes paprika and cayenne pepper which disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_17_724\" id=\"identifier_23_724\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">17<\/a><\/li>\n<li><strong>Alcohol and Caffeine<\/strong>. Disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_17_724\" id=\"identifier_24_724\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">17<\/a>\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Important Anti-Inflammatory Food Types to Promote Health<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li><strong>Fruits<\/strong>.\u00a0Contain ample amounts of vitamins, minerals and phytochemicals which are\u00a0naturally occuring components in plants that detoxify toxins, carcinogens (reducing the risk by 50%) and mutagens.<\/li>\n<li><strong>Non-Starchy Vegetables.<\/strong>\u00a0Support intestinal integrity and provide ample amounts of vitamins, minerals and phytochemicals. Includes green leafy vegetables such as lettuce and kale, also onion, broccoli, garlic, and others.<\/li>\n<li><strong>High Quality Complex Carbohydrates<\/strong>. Provide vitamins, minerals, and fiber while boosting serotonin levels to help you relax and feel calm. Includes whole grains, legumes, and root vegetables such as carrots, parsnips, sweet potatoes, turnips, red beets, and others.<\/li>\n<li><strong>Antioxidants<\/strong>. Protect the body from inflammatory oxidant molecules that continually occur and\u00a0help us handle stress and reduce irritability. Includes vitamin C-containing foods such as lemon, grapefruit, apricot, Brussels sprouts and strawberries, and others. Also, includes vitamin E-containing foods such as\u00a0nuts, seeds, avocado, olive oil, and others. Cocoa is good, too.<\/li>\n<li><strong>Omega-3 Fatty Acids<\/strong>. Balance opposing omega-6 fatty acids and bad fats. Fish sources includes tuna, salmon, cod, and others. Plants sources include flax, chia seeds, canola oil, and others.<\/li>\n<li><strong>Probiotics.\u00a0<\/strong>Supply normal microbes needed for colon health and health of the body such as these fermented foods: yogurt, kefir, and unpasteurized apple cider vinegar.<\/li>\n<li><strong>Prebiotics\/ High Fiber Foods<\/strong>. \u00a0Food with fiber keeps our population of colonic microbes healthy.<\/li>\n<li><strong>Protective Herbs and Spices<\/strong>. \u00a0See below #6 below for examples.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">3<\/span>\u00a0Information Sheet You Can Take to Your Doctor or Other Health Professional:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\">Click here.<\/p>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><span style=\"color: #800000\"><strong><em><span class=\"dropcap\">4<\/span>\u00a0Manage Your Medications\u00a0Safely<\/em>:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">Certain medications deplete one or more of these nutrients that promote schizophrenia in susceptible persons: vitamin C, vitamin B12 (causing paranoia in particular), magnesium, and EPA (omega-3 fatty acid). Ask your doctor or pharmacist about this possible adverse effect if you are taking any of the drugs listed below.\u00a0<strong>Do not stop prescribed medications without supervision.<\/strong><\/p>\n<p style=\"text-align: justify\">This is not a complete listing.<\/p>\n<p style=\"text-align: justify\"><strong>ANTACIDS \/ ULCER MEDICATIONS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Pepcid\u00ae, Tagamet\u00ae, Zantac\u00ae deplete \u00a0Vitamin B12, Magnesium.<\/li>\n<li>Magnesium and Aluminum Antacid preparations (Gaviscon\u00ae, Maalox\u00ae, Mylanta\u00ae) deplete\u00a0Vitamin B12, Magnesium.<\/li>\n<li>Prevacid\u00ae, Prilosec\u00ae\u00a0deplete Vitamin B12.<\/li>\n<li>Alka Seltzer\u00ae, Baking Soda deplete Magnesium.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTI-DEPRESSANTS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Adapin\u00ae, Aventyl\u00ae, Elavil\u00ae, Pamelor\u00ae, and others\u00a0deplete Vitamin B12.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTIBIOTICS\u00a0<\/strong>disrupt intestinal permeability which complicates celiac disease.<\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Gentomycin, Neomycin, Streptomycin, Cephalosporins, Penicillins\u00a0deplete\u00a0B Vitamins, Vitamin C.<\/li>\n<li>\u00a0Tetracyclines deplete Magnesium, Vitamin B6, Riboflavin.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTI-INFLAMMATORIES<\/strong>\u00a0disrupt intestinal permeability which complicates celiac disease.<\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Corticosteroids (Prednisone, Medrol\u00ae, Aristocort\u00ae, Decadron) deplete Magnesium, Vitamin C, Vitamin B6, Vitamin B12, Folic Acid.<\/li>\n<li>NSAIDS (Motrin\u00ae, Aleve\u00ae, Advil\u00ae, Anaprox\u00ae, Dolobid\u00ae, Feldene\u00ae, Naprosyn\u00ae and others) deplete\u00a0Folic acid.<\/li>\n<li>Aspirin and Salicylates deplete Folic acid, Vitamin C, Pantothenate (vitamin B5).<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTICONVULSANTS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Phenobarbital and Barbituates; and Dilantin\u00ae, Tegretol\u00ae, Mysoline\u00ae, Depakane\/Depacon\u00ae deplete Folic Acid, Biotin, Vitamin B12, Vitamin B1.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTIVIRAL AGENTS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Zidovudine (Retrovir\u00ae, AZT and other related drugs) deplete Vitamin B12.<\/li>\n<li>Foscanet depletes Magnesium.<strong>\u00a0<\/strong><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>CARDIOVASCULAR DRUGS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Antihypertensives (Catapres\u00ae, Aldomet) deplete \u00a0Vitamin B6, Vitamin B1.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>CHOLESTEROL DRUGS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Colestid\u00ae and Questran\u00ae deplete Vitamin B12, Folic Acid.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>DIABETIC DRUGS\u00a0<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Metformin\u00ae depletes\u00a0Folic acid, Vitamin B12.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>DIURETICS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Thiazide Diuretics (Hydrochlorothiazide, Enduron\u00ae, Diuril\u00ae, Lozol\u00ae, Zaroxolyn\u00ae, Hygroton\u00ae and others) deplete Magnesium.<\/li>\n<li>Loop Diuretics (Lasix\u00ae, Bumex\u00ae, Edecrin\u00ae) deplete Magnesium, Vitamin B1, Vitamin B6, Vitamin C.<\/li>\n<li>Potassium Sparing Diuretics (Midamor\u00ae, Aldactone\u00ae, Dyrenium\u00ae and others) deplete Folic Acid.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>FEMALE HORMONES<\/strong>\u00a0disrupt intestinal permeability which complicate celiac disease.<\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Oral Contraceptives (Norinyl\u00ae, Ortho-Novum\u00ae, Triphasil\u00ae, and others) deplete Vitamin B2, Vitamin B3, Vitamin B6, Vitamin B12, Vitamin C, Folic Acid, Magnesium.<\/li>\n<li>Oral Estrogen\/Hormone Replacement (Evista\u00ae, Prempro\u00ae, Premarin\u00ae, Estratab\u00ae and others) deplete\u00a0Vitamin B2, Vitamin B6, Vitamin B12, Vitamin C, Folic Acid, Magnesium.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>MAJOR TRANQUILIZERS<\/strong>\u00a0<strong>\u00a0<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Thorazine\u00ae, Mellaril\u00ae, Prolixin\u00ae, Serentil\u00ae and others\u00a0deplete\u00a0Coenzyme Q10, Vitamin B12.<\/li>\n<\/ul>\n<p style=\"text-align: justify\">\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">5<\/span>Nutritional Supplements To Help Correct Deficiencies:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">The type and quantity of nutritional supplements that may be needed depend on which nutrients are deficient.<\/p>\n<ul class=\"cp_bullet orange\" style=\"text-align: justify\">\n<li>Multivitamin\/mineral combination once a day is useful to improve overall nutrient levels. This is a safe dose, but always check with your doctor to avoid interactions with medications.<\/li>\n<li>Vitamin C in a natural form such as Ester-C.<\/li>\n<li>Vitamin B12 as prescribed following blood test for status.<\/li>\n<li>Chelated magnesium\u00a0\u00a0as prescribed but do not take at same time as calcium because they compete for absorption.<\/li>\n<li>Fish oil supplements to obtain EPA (omega-3 fatty acid).<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Storage Note<\/strong>:\u00a0<em>Store container tightly sealed, away from heat, moisture and direct light to avoid loss of potency. That is, in a safe kitchen cabinet &#8211; not in the bathroom or on the kitchen table. Fish oil goes in the refrigerator<\/em>.\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><span style=\"color: #800000\"><em><strong><span class=\"dropcap\">6<\/span>Manage Natural Remedies:\u00a0<\/strong><\/em><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Hydration<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eight glasses of water are recommended per day unless there is a contraindication such as kidney or heart disease. The Institute of Medicine recommends approximately 2.7 liters (91 ounces) of total water, from all beverages and foods, each day for women and 3.7 liters (125 ounces) daily of total water for men.<\/li>\n<li>If you are thirsty, drink water. Add fresh, squeezed lemon to water. Lemon is anti-inflammatory, alkalizing and provides vitamin C.<\/li>\n<li>Hydration Test: Urine should be pale yellow. Fingertips should be plump, without pruning but this may not be reliable when fingers are swollen with edema. Lips should be plump, without puckering. The feeling of thirst can be unreliable.<\/li>\n<li>What is wrong with soda, coffee, tea, and alcohol? These drinks are dehydrating, increase acid, and deplete nutrients.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Carminatives.\u00a0<\/strong>The following \u00a0anti-inflammatory\u00a0plant sources called carminitives help heal the digestive tract. They also tone the digestive muscles which improves peristalsis, thus aiding in the expulsion of gas from the stomach and intestine to relieve digestive colic and gastric discomfort.<\/p>\n<p style=\"text-align: justify\"><strong>Carminative Food Remedies<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Raspberry.<\/li>\n<li>Carrot is also a cleansing digestive tonic.<\/li>\n<li>Grape is also bile stimulating and a cleansing remedy for sluggish digestion and laxative.<\/li>\n<li>Redbeets also stimulate and improve digestion and are easily digested.<\/li>\n<li>Cabbage also stimulates and improves digestion and is also a liver decongestant.<\/li>\n<li>Lettuce also stimulates and improves digestion and is also an alterative, meaning it improves the function of organs involved with the digestion and excretion of waste products to bring about a gradual change.<\/li>\n<li>Potatoes are antispasmodic (due to atropine like properties) and a liver remedy.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Herb Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Sage is also a digestive, astringent, bile stimulant and energy tonic that heals the mucosa. \u00a0Drink as tea or use in cooking.<\/li>\n<li>Chamomile, lemon balm, and fennel, (as a tea) also help relieve nervous tension.<\/li>\n<li>Parsley also relieves indigestion.<\/li>\n<li>Rosemary as a tea and in cooking also is a nervous system tonic for stress and fatigue, bile stimulant, and can relieve headaches and indigestion.<\/li>\n<li>Thyme is also soothing remedy useful for stimulating digestion of rich, fatty foods.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Spice Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Cloves are also antispasmodic.<\/li>\n<li>Nutmeg is also useful for indigestion.<\/li>\n<li>Ginger.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Exercise Helps<\/strong>:<\/p>\n<p style=\"text-align: justify\">Exercise improves circulation and rids the body of toxins.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Walking is aerobic exercise that reconditions the whole body to improve stamina.\u00a0Read more about<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">\u00a0Exercise and Fitness<\/a>.<\/li>\n<li>Weight training builds muscle.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<li>Stretching improves flexibilty.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Note<\/strong>: Exercise is important, but the amount and type of exercise undertaken depends on your health. Your first priority is to heal. \n\t\t\t<\/div><\/div>\n<h2 style=\"text-align: justify\">What Do Medical Research Studies Tell About Schizophrenia In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<h4><strong>RESEARCH STUDY SUMMARIES<\/strong><\/h4>\n<p style=\"text-align: justify\"><strong>&#8220;Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia.&#8221;<\/strong> This study investigating the relationship between gluten sensitivity and schizophrenia shows that identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.<\/p>\n<p style=\"text-align: justify\">100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels in schizophrenia (2.9\u00b17.7 vs. 1.3\u00b11.3, p=0.046, controlled for age).<\/p>\n<p style=\"text-align: justify\">Additionally, examination of symptoms within the schizophrenia group found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11\u00b11.36 vs. 6.39\u00b12.99, p=0.020), no robust clinical profile (set of symptoms) differentiates between positive and negative antibody groups.<a href=\"#footnote_18_724\" id=\"identifier_25_724\" class=\"footnote-link footnote-identifier-link\" title=\"Jackson J, Eaton W, Cascella N, Fasano A, Santora D, Sullivan K, Feldman S, Raley H, McMahon RP, Carpenter WT Jr, Demyanovich H, Kelly DL. Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia. Schizophr Res. 2014 Oct 10. pii: S0920-9964(14)00511-8. doi: 10.1016\/j.schres.2014.09.023.\">18<\/a><\/p>\n<p style=\"text-align: justify\"><strong>&#8220;Biomarkers of gluten sensitivity in patients with non-affective psychosis: a meta-analysis.&#8221;<\/strong> This systematic literature review investigated which serum biomarkers of gluten sensitivity are elevated in patients with schizophrenia in original articles that measured biomarkers of gluten sensitivity in patients with schizophrenia and non-affective psychoses compared to a control group. Findings show that not all serum biomarkers of gluten sensitivity are elevated in patients with schizophrenia. However, the specific immune response to gluten in this population differs from that found in patients with celiac disease.<\/p>\n<p style=\"text-align: justify\">Three databases were used: Ovid MEDLINE, Psych INFO, and Embase, dating back to 1946. Forward tracking and backward tracking were undertaken on retrieved papers. A meta-analysis was performed of specific biomarkers and reported according to MOOSE guidelines.<\/p>\n<p style=\"text-align: justify\">In 12 relevant original articles 5 biomarkers of gluten sensitivity were found to be significantly elevated in patients with non-affective psychoses compared to controls: Anti-Gliadin IgG , Anti-Gliadin IgA , Anti-TTG2 IgA, Anti-Gliadin (unspecified isotype), and Anti-Wheat.<\/p>\n<p style=\"text-align: justify\">Four biomarkers for gluten sensitivity, Anti-EMA IgA, Anti-TTG2 IgG, Anti-DGP IgG, and Anti-Gluten were not found to be associated with schizophrenia.<a href=\"#footnote_4_724\" id=\"identifier_26_724\" class=\"footnote-link footnote-identifier-link\" title=\"Lachance LR, McKenzie K. Biomarkers of gluten sensitivity in patients with non-affective psychosis: a meta-analysis. Schizophr Res. 2014 Feb;152(2-3):521-7. doi: 10.1016\/j.schres.2013.12.001.\">4<\/a><\/p>\n<p style=\"text-align: justify\"><strong>&#8220;Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients.&#8221;<\/strong> This analysis focuses on transglutaminase 6 (tTG6) antibodies (show brain inflammation) in schizophrenia (SZ) and its relationships to raised tTG2 and to antigliadin antibodies to try to understand why an increased prevalence of tTG2 antibodies in gluten sensitive SZ patients compared with healthy controls was not paralleled by an increased prevalence of antiendomysial antibody which is a marker for celiac disease.<\/p>\n<p style=\"text-align: justify\">To elucidate this discrepancy, researchers examined those tTG2 positive SZ patients from a previous study for the presence of tTG6 antibody and also searched for tTG6 antibodies in their sample of antigliadin (AGA) positive and AGA and tTG2 negative SZ patients. Seventy-four tTG2 positive SZ patients were compared with 148 age and gender-matched healthy controls. Of the 74 tTG2 positive SZ patients, 16 were positive for tTG6 IgA for a prevalence of 22%. Only 4 healthy controls were positive for tTG6 IgA for a prevalence of 2.7%.<\/p>\n<p style=\"text-align: justify\">Among the AGA positive SZ patients, the prevalence of tTG6 IgA was 21.3% while 13.1% of the AGA and tTG2 negative SZ patients were positive for tTG6 IgA. The healthy controls \u00a0had a prevalence of 6%. Results indicate a higher prevalence of tTG6 antibodies in SZ that may represent a biomarker useful to identify SZ patients who would benefit from a gluten-free diet.<a href=\"#footnote_19_724\" id=\"identifier_27_724\" class=\"footnote-link footnote-identifier-link\" title=\"Cascella NG, Santora D, Gregory P, Kelly DL, Fasano A, Eaton WW. Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients. Schizophr Bull. 2013 Jul;39(4):867-71. doi: 10.1093\/schbul\/sbs064.\">19<\/a><\/p>\n<p style=\"text-align: justify\"><strong>&#8220;Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population.&#8221;<\/strong> This study investigating antibody prevalence to gliadin (AGA), transglutaminase (tTG), and endomysium (EMA) in a group of individuals with schizophrenia and a comparison group found that persons with schizophrenia have higher than expected titers of antibodies related to celiac disease and gluten sensitivity.<\/p>\n<p>AGA, tTG, and EMA antibodies were assayed in 1401 schizophrenia patients who were part of the Clinical Antipsychotic Trials of Intervention Effectiveness study and 900 controls. Psychopathology in schizophrenia patients was assessed using the Positive and Negative Symptoms Scale (PANSS). Logistic regression was used to assess the difference in the frequency of AGA, immunoglobulin A (IgA), and tTG antibodies, adjusting for age, sex, and race.<\/p>\n<p>Among schizophrenia patients, 23.1% had moderate to high levels of IgA-AGA compared with 3.1% of the comparison group. \u00a0Moderate to high levels of tTG antibodies were present in 5.4% of schizophrenia patients vs 0.80% of the comparison group. \u00a0Adjustments for sex, age, and race had trivial effects on the differences.<a href=\"#footnote_20_724\" id=\"identifier_28_724\" class=\"footnote-link footnote-identifier-link\" title=\"Cascella NG, Kryszak D, Bhatti B, Gregory P, Kelly DL, Mc Evoy JP, Fasano A, Eaton WW. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull. 2011 Jan;37(1):94-100. doi: 10.1093\/schbul\/sbp055.\">20<\/a><\/p>\n<p style=\"text-align: justify\"><strong>&#8220;Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia.&#8221;<\/strong> This study investigating increased immune sensitivity to gluten in schizophrenia found that individuals with recent-onset psychosis and with multi-episode schizophrenia who have increased antibodies to gliadin may share some immunologic features of celiac disease, but their immune response to gliadin differs from that of celiac disease.<\/p>\n<p style=\"text-align: justify\">The sample of 471 individuals included 129 with recent-onset psychosis, 191 with multi-episode schizophrenia, and 151 controls. Immunoglobulin (Ig)G and IgA antibodies to gliadin and to tissue transglutaminase, and IgG antibodies to deamidated gliadin were measured. Quantitative levels of antibodies in the psychiatric groups were compared with controls. All participants were categorized as to whether their levels of antibodies met standardized cutoffs for celiac disease. HLA DQ2 and HLA DQ8 alleles were detected by real-time polymerase chain reaction.<\/p>\n<p style=\"text-align: justify\">Individuals with recent-onset psychosis had increased levels of IgG (odds ratio [OR] 5.50; 95% confidence interval [CI] 2.65-11.42) and IgA (OR 2.75; 95% CI 1.31-5.75) antibodies to gliadin compared with control subjects. Individuals with multi-episode schizophrenia also had significantly increased levels of IgG antibodies to gliadin (OR 6.19; 95% CI 2.70-14.16).<br \/>\nIgG antibodies to deamidated gliadin and IgA antibodies to tissue transglutaminase (tTG) were not elevated in either psychiatric group, and fewer than 1% of individuals in each of the groups had levels of these antibodies predictive of celiac disease. There were no significant differences in the distribution of the HLA DQ2\/8 alleles among the groups.<a href=\"#footnote_21_724\" id=\"identifier_29_724\" class=\"footnote-link footnote-identifier-link\" title=\"Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Leister F, Yang S, Krivogorsky B, Alaedini A, Yolken R. Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia. Biol Psychiatry. 2010 Jul 1;68(1):100-4. doi: 10.1016\/j.biopsych.2010.03.021.\">21<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cSpecific IgA antibody increases in schizophrenia.\u201d<\/strong> This study demonstrated more schizophrenics than controls showed IgA antibody levels above the upper limit to gliadin from wheat and beta-lactoglobulin and casein from cow&#8217;s milk.<a href=\"#footnote_22_724\" id=\"identifier_30_724\" class=\"footnote-link footnote-identifier-link\" title=\"Reichelt KL, Landmark J. Specific IgA antibody increases in schizophrenia. Biological psychiatry. Mar 15, 1995;37(6):410-3.\">22<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cIs schizophrenia rare if grain is rare?\u201d<\/strong> This study testing the hypothesis that neuroactive peptides from gluten grains are major agents evoking schizophrenia in those with the genotypes demonstrated gluten is harmful.<a href=\"#footnote_23_724\" id=\"identifier_31_724\" class=\"footnote-link footnote-identifier-link\" title=\"Dohan FC, Harper EH, Clark MH, Rodriguez RB, Zigas V. Is schizophrenia rare if grain is rare?Biological Psychiatry. Mar 1984;19(3):385-99.\">23<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cDemonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates.\u201d<\/strong> This study determining the origin of peptides that exhibit opioid activity demonstrated a high opioid-like activity in isolated peptides from wheat gluten hydrolysates. While some peptides showed no activity, 0.5mg of the most active peptides were equivalent to 1 nM of morphine in the binding assay and were derived from the gliadin fraction of gluten.<a href=\"#footnote_7_724\" id=\"identifier_32_724\" class=\"footnote-link footnote-identifier-link\" title=\"Huebner FR, Lieberman KW, Rubino RP, Wall JS. Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates. Peptides. Nov-Dec 1984;5(6):1139-47.\">7<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cWheat gluten as a pathogenic factor in schizophrenia.\u201d<\/strong> This study demonstrated that gluten exerts a primary schizophrenia-promoting effect evidenced by improvement with gluten withdrawal and exacerbation with reinstatement.<a href=\"#footnote_15_724\" id=\"identifier_33_724\" class=\"footnote-link footnote-identifier-link\" title=\"Singh MM, Kay SR. Wheat gluten as a pathogenic factor in schizophrenia. Science. Jan 30, 1976;191(4225):401-2.\">15<\/a><\/p>\n<p style=\"text-align: justify\"><strong>CASE REPORT SUMMARIES<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>&#8220;Psychosis revealing a silent celiac disease in a young woman with trisomy 21.\u201d<\/strong>\u00a0This case report of a patient with Down&#8217;s syndrome with psychosis, describes subsequent diagnosis of Celiac Disease with spectacular and lasting improvement after 12 months on a Gluten Free Diet.<a href=\"#footnote_24_724\" id=\"identifier_34_724\" class=\"footnote-link footnote-identifier-link\" title=\"Serratrice J, Disdier P, Kaladjian A, et al. Psychosis revealing a silent celiac disease in a young woman with trisomy 21.La Presse Medicale. Oct 12, 2002;31(33):1551-3.\">24<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cSchizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet.&#8221;<\/strong>\u00a0This case report of SPECT examination of a patient with &#8220;schizophrenic disorder&#8221; with undiagnosed and untreated Celiac Disease demonstrated hypoperfusion (low blood flow) of the left frontal brain area, without structural cerebral abnormalities. Dysfunction disappeared after Gluten Free Diet.<a href=\"#footnote_25_724\" id=\"identifier_35_724\" class=\"footnote-link footnote-identifier-link\" title=\"De Santis A, Addolarato G, Romito A, et al. Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet. Journal of Internal Medicine. Nov 1997;242(5):421-3.\">25<\/a><\/p>\n<ol class=\"footnotes\"><li id=\"footnote_1_724\" class=\"footnote\">Pagsberg AK, Tarp S, Glintborg D, Stenstr\u00f8m AD, Fink-Jensen A, Correll CU, Christensen R. Antipsychotic treatment for children and adolescents with schizophrenia spectrum disorders: protocol for a network meta-analysis of randomised trials. <em>BMJ Open.<\/em> 2014 Oct 10;4(10):e005708. doi: 10.1136\/bmjopen-2014-005708.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_724\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_2_724\" class=\"footnote\">Jessica R. Jackson, William W. Eaton, Nicola G. Cascella, Alessio Fasano, and Deanna L. Kelly Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity. Psychiatr Q. 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Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull. 2011 Jan;37(1):94-100. doi: 10.1093\/schbul\/sbp055.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_28_724\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_21_724\" class=\"footnote\">Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Leister F, Yang S, Krivogorsky B, Alaedini A, Yolken R. Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia. <em>Biol Psychiatry<\/em>. 2010 Jul 1;68(1):100-4. doi: 10.1016\/j.biopsych.2010.03.021.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_29_724\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_22_724\" class=\"footnote\">Reichelt KL, Landmark J. Specific IgA antibody increases in schizophrenia. <em>Biological psychiatry<\/em>. Mar 15, 1995;37(6):410-3.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_30_724\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_23_724\" class=\"footnote\">Dohan FC, Harper EH, Clark MH, Rodriguez RB, Zigas V. Is schizophrenia rare if grain is rare?<em>Biological Psychiatry<\/em>. Mar 1984;19(3):385-99.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_31_724\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_24_724\" class=\"footnote\">Serratrice J, Disdier P, Kaladjian A, et al. Psychosis revealing a silent celiac disease in a young woman with trisomy 21.<em>La Presse Medicale<\/em>. Oct 12, 2002;31(33):1551-3.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_34_724\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_25_724\" class=\"footnote\">De Santis A, Addolarato G, Romito A, et al. Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet. <em>Journal of Internal Medicine<\/em>. Nov 1997;242(5):421-3.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_35_724\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>What Is Schizophrenia? Schizophrenia is a thought disorder characterized by psychotic symptoms and inappropriate and bizarre behavior. Schizophrenia involves dysfunction in any of these areas: Cognition which are thinking skills that include intellect, language, mathematical ability, memory, perception, reasoning, judgment, learning, and imagination. Interpersonal relationships. Ability to work or attend education. Ability to take care &#8230;<\/p>\n","protected":false},"author":29,"featured_media":3373,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4,779,144,969,117,200,49,107,126],"tags":[445,101,1059,1075,1926,1076,1081,1080,286,1079,2002,1077,776,1078,1912,1961,891,1887,1905,1920],"class_list":["post-724","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-conditions-2","category-associated-disorder","category-brain","category-genetic","category-magnesium","category-mind","category-nervous-2","category-vitamin-b12","category-vitamin-c","tag-apathy","tag-associated-disorders","tag-atypical","tag-bizarre-behavior","tag-brain","tag-delusions","tag-disorganized-behavior","tag-disorganized-speech","tag-epa","tag-flat-affect","tag-genetic","tag-hallucinations","tag-health-conditions","tag-lack-of-insight","tag-magnesium","tag-mind","tag-schizophrenic-symptoms","tag-nervous-2","tag-vitamin-b12","tag-vitamin-c"],"_links":{"self":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/comments?post=724"}],"version-history":[{"count":35,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/724\/revisions"}],"predecessor-version":[{"id":18805,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/724\/revisions\/18805"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media\/3373"}],"wp:attachment":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media?parent=724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/categories?post=724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/tags?post=724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}