{"id":664,"date":"2016-10-03T22:08:47","date_gmt":"2016-10-04T02:08:47","guid":{"rendered":"http:\/\/www.mynutriguide.com\/?p=664"},"modified":"2020-07-11T10:38:19","modified_gmt":"2020-07-11T14:38:19","slug":"depression-3","status":"publish","type":"post","link":"https:\/\/glutenfreeworks.com\/health\/depression-3\/","title":{"rendered":"Depression"},"content":{"rendered":"<h2><a href=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/stock-photo-3443895-depression-and-sorrow1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-8579\" style=\"margin-left: 3px;margin-right: 3px\" src=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/stock-photo-3443895-depression-and-sorrow1-216x300.jpg\" alt=\"Depression and gluten\" width=\"216\" height=\"300\" srcset=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/stock-photo-3443895-depression-and-sorrow1-216x300.jpg 216w, https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/stock-photo-3443895-depression-and-sorrow1.jpg 588w\" sizes=\"auto, (max-width: 216px) 100vw, 216px\" \/><\/a>What Is Depression?<\/h2>\n<p style=\"text-align: justify\"><span class=\"dropcap\">D<\/span>epression is a mood disorder characterized by absence of cheerfulness, dejection, and loss of interest or pleasure in living, making the person dysfunctional and unable to cope with or perform tasks of daily living.<\/p>\n<p style=\"text-align: justify\">More than a feeling, this negative psychological status can range from mild to profound\u00a0and can involve other parts of the body, causing physical problems such as poor digestion, constipation, weight gain or weight loss, mentrual irregularities in females, and impotence in males.<\/p>\n<p style=\"text-align: justify\"><strong>Q<\/strong>: How is depression identified?<\/p>\n<p style=\"text-align: justify\"><strong>A<\/strong>: According to the American Psychiatric Association, depression is a psychic condition that lasts for more than a month and involves four or more of these symptoms:<\/p>\n<ul class=\"cp_bullet black\">\n<li>Abnormal appetite.<\/li>\n<li>Diminished ability to concentrate or think properly.<\/li>\n<li>Feelings of worthlessness.<\/li>\n<li>Low energy or fatigue.<\/li>\n<li>Physical inactivity or hyperactivity.<\/li>\n<li>Sleep disturbances.<\/li>\n<li>Thoughts of death.<\/li>\n<\/ul>\n<p style=\"text-align: justify\">Grief or sadness at the loss of a loved one or a similar event or remorse for sin is normal. However, depression that is prolonged usually involves imbalances of nerve chemicals called neurotransmitters. Imbalances can result from health disorders such as hormonal imbalances, low blood sugar, stress, drug side effects, or nutrient deficiencies.<\/p>\n<h2>What Is Depression In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p><!--more--><\/p>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and celiac disease<\/strong>: Depression is a pschychological feature of adult celiac disease that appears in untreated and treated celiac disease patients.<\/li>\n<\/ul>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and malabsorption<\/strong>: Malabsorption that is typical of celiac disease results in deficiency of amino acids and vitamins which implicate reduced production of brain neuro-transmitters (chemicals) producing depression.<a href=\"#footnote_1_664\" id=\"identifier_1_664\" class=\"footnote-link footnote-identifier-link\" title=\"Potocki P, Hozyasz K. Psychiatric symptoms and coeliac disease. Psychiatria Polska. Jul-Aug 2002;36(4):567-78.\">1<\/a><\/li>\n<\/ul>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and magnesium<\/strong>: &#8220;There is more than sufficient evidence to implicate inadequate dietary magnesium as the main cause of treatment-resistant depression (TRD), and that physicians should prescribe magnesium for TRD. Since inadequate brain magnesium appears to reduce serotonin levels, and since anti-depressants have been shown to have the action of raising brain magnesium, we further hypothesize that magnesium treatment will be found beneficial for nearly all depressives, not only TRD.&#8221;<a href=\"#footnote_2_664\" id=\"identifier_2_664\" class=\"footnote-link footnote-identifier-link\" title=\"Eby GA 3rd, Eby KL. Magnesium for treatment-resistant depression: a review and hypothesis. Med Hypotheses. 2010 Apr;74(4):649-60. doi: 10.1016\/j.mehy.2009.10.051.\">2<\/a><\/li>\n<\/ul>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and pyridoxine (vitamin B6)<\/strong>:\u00a0Importantly, after 3 years, following 6 months of\u00a080 mg\/day of oral pyridoxine therapy, scores for newly treated patients became normalized indicating a causal relationship between adult celiac disease and concomitant depressive symptoms and implicating metabolic effects from pyridoxine deficiency.<a href=\"#footnote_3_664\" id=\"identifier_3_664\" class=\"footnote-link footnote-identifier-link\" title=\"Hallert C, Astrom J, Walan A. Reversal of psychopathology in adult coeliac disease with the aid of pyridoxine (vitamin B6). Scandanavian Journal of Gastroenterology. Mar 1983;18(2):299-304.\">3<\/a><\/li>\n<\/ul>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and EPA (eicosapentaenoic acid).\u00a0<\/strong>A meta-analysis on the effects of omega 3 fatty acids on depression confirmed the hypothesis that EPA is the effective nutrient protective against depression rather than the omega 3 fatty acid DHA (docosahexaenoic acid).<a href=\"#footnote_4_664\" id=\"identifier_4_664\" class=\"footnote-link footnote-identifier-link\" title=\"Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014 May 7;9(5):e96905. doi: 10.1371\/journal.pone.0096905. eCollection 2014.\">4<\/a><\/li>\n<\/ul>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and fatigue<\/strong>: A study investigating fatigue and quality-of-life in 51 patients showed that fatigue is strictly correlated to depression and that the greater the fatigue the worse the quality of life scores.\u00a0Fatigue severity was also greater in patients with worse quality of life (13 vs. 2). Multiple regression analysis showed fatigue to be an independent determinant of quality of life.<a href=\"#footnote_5_664\" id=\"identifier_5_664\" class=\"footnote-link footnote-identifier-link\" title=\"Jord&aacute; FC, L&oacute;pez Vivancos J. Fatigue as a determinant of health in patients with celiac disease. J Clin Gastroenterol. 2010 Jul;44(6):423-7. doi: 10.1097\/MCG.0b013e3181c41d12.\">5<\/a><\/li>\n<\/ul>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and stress.\u00a0<\/strong>Psychological stress is produced in celiac disease both by the effects of gluten and by insufficiency of many nutrients. Such stress activates multiple physiological processes aimed at maintaining balance within the body. However, these physiological processes also have the capacity to influence the composition of microbial communities in the digestive tract, and research now indicates that exposure to stressful stimuli leads to gut dysbiosis.<a href=\"#footnote_6_664\" id=\"identifier_6_664\" class=\"footnote-link footnote-identifier-link\" title=\"Galley JD, Bailey MT. Impact of stressor exposure on the interplay between commensal microbiota and host inflammation.&nbsp;Gut Microbes. 2014 May 1;5(3):390-396. Epub 2014 Apr 1.\">6<\/a> Importantly, dysbiosis in turn causes brain fog (impaired thinking and memory), headache, and fatigue which adds to depression.<\/li>\n<\/ul>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and response to gluten after diagnosis.\u00a0<\/strong>Fully gluten free diet adherent patients are more likely to have symptomatic responses to dietary gluten (SRDG) less than 1hr than patients who are partial\/none adherent as are those patients at risk of both anxiety and depression. That is, anxiety and depression enhance the speed of symptom onset, and inadvertent exposure to dietary gluten in the fully gluten free diet adherent group is more likely to result in a severe SRDG in comparison to symptoms arising prior to consistent gluten free diet adherence.<a href=\"#footnote_7_664\" id=\"identifier_7_664\" class=\"footnote-link footnote-identifier-link\" title=\"Barratt SM, Leeds JS, Sanders DS. Factors influencing the type, timing and severity of symptomatic responses to dietary gluten in patients with biopsy-proven coeliac disease. J Gastrointestin Liver Dis. 2013 Dec;22(4):391-6.\">7<\/a><\/li>\n<\/ul>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between depression and gluten free diet<\/strong>: The role of a gluten free diet on psychological disorders is poorly known. Depression that is initially present as a consequence of celiac disease symptoms and malabsorption\/malnutrition, \u00a0may be sustained after treatment with gluten restriction by reduced quality of life related in part to decreased sense of well-being, and in part to dietary restrictions, leading to social difficulties.<a href=\"#footnote_8_664\" id=\"identifier_8_664\" class=\"footnote-link footnote-identifier-link\" title=\"Addolorato G, Capristo E, Ghittoni G, et al. Anxiety but not depression decreases in coeliac patients after one-year gluten-free diet: a longitudinal study. Scandanavian Journal of Gastroenterology. May 2001;36(5):502-6.\">8<\/a><\/li>\n<\/ul>\n<h2>How Prevalent Is Depression In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p style=\"text-align: justify\">Depression is typical in adults at diagnosis of celiac disease.<a href=\"#footnote_3_664\" id=\"identifier_9_664\" class=\"footnote-link footnote-identifier-link\" title=\"Hallert C, Astrom J, Walan A. Reversal of psychopathology in adult coeliac disease with the aid of pyridoxine (vitamin B6). Scandanavian Journal of Gastroenterology. Mar 1983;18(2):299-304.\">3<\/a><\/p>\n<p style=\"text-align: justify\">In a postal survey of 224 biopsy-proven patients with celiac disease, prevalence of depression numbered 33 (14%) while anxiety &amp; depression numbered 72 (32%).<a href=\"#footnote_7_664\" id=\"identifier_10_664\" class=\"footnote-link footnote-identifier-link\" title=\"Barratt SM, Leeds JS, Sanders DS. Factors influencing the type, timing and severity of symptomatic responses to dietary gluten in patients with biopsy-proven coeliac disease. J Gastrointestin Liver Dis. 2013 Dec;22(4):391-6.\">7<\/a><\/p>\n<h2>What Are The Symptoms Of Depression In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p style=\"text-align: justify\">Depression is marked by these general symptoms and others specifically caused by nutritional deficiencies:<\/p>\n<ul class=\"cp_bullet red\">\n<li>Fatigue or lack of energy.<\/li>\n<li>Headache.<\/li>\n<li>Inability to think normally.<\/li>\n<li>Insomnia or excessive sleep.<\/li>\n<li>Irritability.<\/li>\n<li>Persistent feelings of guilt\/ self-criticism.<\/li>\n<li><span style=\"text-align: justify;line-height: 1.5em\">Physical inactivity or hyperactivity.<\/span><\/li>\n<li><span style=\"text-align: justify;line-height: 1.5em\">Poor concentration.<\/span><\/li>\n<li><span style=\"text-align: justify;line-height: 1.5em\">Recurring thoughts of suicide\/ death are possible.<\/span><\/li>\n<li><span style=\"text-align: justify;line-height: 1.5em\">Sense of worthlessness.<\/span><\/li>\n<\/ul>\n<h2>How Does Depression In Celiac Disease and\/or Gluten Sensitivity Develop?<\/h2>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\">Depression results from unclear etiology involving malabsorption, immunological disregulation,<a href=\"#footnote_9_664\" id=\"identifier_11_664\" class=\"footnote-link footnote-identifier-link\" title=\"Potocki P, Hozyasz K. Psychiatric symptoms and coeliac disease. Psychiatria Polska. Jul-Aug 2002;36(4):567-78.\">9<\/a> and cerebral blood flow alterations in celiac disease.<\/li>\n<\/ul>\n<ul class=\"cp_bullet red\">\n<li style=\"text-align: justify\">Nutritional deficiencies known to be involved in depression include EPA omega-3 fatty acid, magnesium, potassium, niacin (vitamin B3), vitamin B12, pyridoxine (vitamin B6), vitamin C, zinc, and amino acids. Tryptophan is an amino acid needed for making serotonin and tyrosine is needed for making adrenaline and the neurotransmitters dopamine and norepinephrine.<\/li>\n<li style=\"text-align: justify\">Serotonin theory. This theory is incomplete but suggests that L-tryptophan and serotonin may be involved in the pathophysiologic link between gluten mediated immune responses and depression. Serotonin is a brain chemical that influences mood for the bettter. One study found that a majority of adolescents with celiac disease displayed depressive and behavioral symptoms before the diagnosis of celiac disease and had low free tryptophan levels (used to make serotonin). A gluten free diet was found to improve depressive symptoms and behavioral problems and increase free L-tryptophan levels. After 1 year on a gluten free diet, patients with celiac disease experienced a significant increase in major serotonin and dopamine metabolite concentrations.<a href=\"#footnote_10_664\" id=\"identifier_12_664\" class=\"footnote-link footnote-identifier-link\" title=\"Jessica R. Jackson, William W. Eaton, Nicola G. Cascella, Alessio Fasano, and Deanna L. Kelly Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity. Psychiatr Q. Mar 2012; 83(1): 91&ndash;102. doi:&nbsp; 10.1007\/s11126-011-9186-y\">10<\/a><\/li>\n<li style=\"text-align: justify\">Brain blood flow. Untreated celiac disease patients demonstrated evidence of regional cerebral blood flow alteration. In a study of untreated patients with celiac disease, 73% had at least one hypoperfused brain area vs. 7% of patients on a gluten free diet and none of controls.<a href=\"#footnote_11_664\" id=\"identifier_13_664\" class=\"footnote-link footnote-identifier-link\" title=\"Addolorato G, Di Giuda D, De Rossi G, et al. Regional cerebral hypoperfusion in patients with celiac disease.&nbsp;American Journal of Medicine. Mar 1, 2004;116(5):312-7.\">11<\/a><\/li>\n<\/ul>\n<h2>Does Depression Respond To Gluten-Free Diet?<\/h2>\n<p style=\"text-align: justify\">Yes. Improvement can be obtained on gluten free diet containing adequate nutrition. May require nutritional supplementation especially if depression is due to any or all of these nutrients: vitamin B6 (pyridoxine)<a href=\"#footnote_12_664\" id=\"identifier_14_664\" class=\"footnote-link footnote-identifier-link\" title=\"Hallert C, Astrom J, Walan A. Reversal of psychopathology in adult coeliac disease with the aid of pyridoxine (vitamin B6).&nbsp;Scandanavian Journal of Gastroenterology. Mar 1983;18(2):299-304.\">12<\/a>, magnesium,<a href=\"#footnote_13_664\" id=\"identifier_15_664\" class=\"footnote-link footnote-identifier-link\" title=\"Eby GA 3rd, Eby KL. Magnesium for treatment-resistant depression: a review and hypothesis. Med Hypotheses. 2010 Apr;74(4):649-60. doi: 10.1016\/j.mehy.2009.10.051.\">13<\/a>, and the omega-3 fatty acid EPA.<a href=\"#footnote_4_664\" id=\"identifier_16_664\" class=\"footnote-link footnote-identifier-link\" title=\"Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014 May 7;9(5):e96905. doi: 10.1371\/journal.pone.0096905. eCollection 2014.\">4<\/a><\/p>\n<h2>6 Steps To Improve Depression In Celiac Disease and\/or Gluten Sensitivity:<\/h2>\n<ul class=\"cp_check green\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>1<\/strong><\/span><\/span><strong><span style=\"color: #800000\">Remove the Trigger. Maintain a Strict, Nutritious Gluten Free Diet:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<b>Treatment<\/b>. This condition responds to the complete elimination of gluten, which is the required treatment that improves both depression and gut health.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Gut health is the foundation to restore ALL health. Restored health will enable you to maintain a strict gluten free diet, just as other life tasks will be easier.<\/li>\n<li>A strict gluten free diet means removing 100% of wheat, barley, rye and oats from the diet.<\/li>\n<li>Cutting out bread and other obvious sources of gluten is not good enough for recovery. Even 1\/8th teaspoon of flour or bread crumb is enough to sustain the inflammation that is damaging your small intestine, causing increased permeability (leaky gut) and allowing undigested gluten to enter your body where it can damage structures and function, and instigate immune inflammatory responses.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Correct Your Individual Nutritional Needs.<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eat foods that can replenish missing nutrients. Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<li>Take nutritional supplements as needed.\u00a0Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Recovery<\/strong>. You should begin to feel better within a week and notice more energy as inflammation subsides and the \u00a0absorbing cells that make up the surface lining of your small intestine are better able to function.<\/p>\n<ul class=\"cp_bullet green\">\n<li style=\"text-align: justify\">Intestinal lining cells are replaced every 5 days. The healing process is like sunburn where the damaged surface layer of skin sloughs off and is replaced with new normal cells.<\/li>\n<li style=\"text-align: justify\">Leaky gut normally resolves in two month after starting a gluten free diet and brings about a big improvement in health. Improvement in intestinal permeability precedes morphometric recovery (cell appearance and structure) of the small intestine in celiac disease.<a href=\"#footnote_14_664\" id=\"identifier_17_664\" class=\"footnote-link footnote-identifier-link\" title=\"Cummins AG, Thompson FM, Butler RN, et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease.&nbsp;Clinical Science. Apr 2001;100(4):379-86.\">14<\/a><\/li>\n<li style=\"text-align: justify\">The intestinal lining may take up to a year to heal.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>2<\/strong><\/span><\/span><strong><span style=\"color: #800000\">\u00a0Reduce Inflammation. Foods to Eat and Foods Not to Eat:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p>Because gluten is inflammatory, eliminate OTHER inflammatory foods from your diet to reduce an additive effect to gluten. At the same time, try to eat foods that reduce inflammation (anti-inflammatory).<\/p>\n<div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Major Inflammatory Food Types That Reduce Healing<\/strong>:<\/p>\n<ul class=\"cp_bullet red\">\n<li style=\"text-align: justify\"><strong>Damaging Foods<\/strong>. In susceptible persons, includes corn, dairy (cow), and soy. Lactose, the sugar in any animal milk disrupts intestinal permeability causing leaky gut.<a href=\"#footnote_15_664\" id=\"identifier_18_664\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">15<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Allergenic Foods<\/strong>. Includes foods that trigger the immune sytem to produce IgE antibodies. Allergy testing is the usual way to discover these offending foods.<\/li>\n<li style=\"text-align: justify\"><strong>Shelf Stable Processed Foods.\u00a0<\/strong>Includes any that contain additives and preservatives. Look for them on the nutrition label of the box or package. Additives and preservatives also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_15_664\" id=\"identifier_19_664\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">15<\/a>\u00a0Many cause cancer such as polysorbate 60, potassium bromate, and sodium nitrate.<\/li>\n<li style=\"text-align: justify\"><strong>Fats.<\/strong>\u00a0Limit deep fried foods, trans-fats, saturated fats (animal fat\/butter), and EXCESSIVE omega-6 fatty acid oils like corn oil. Rancid fats, sodium caprate (a medium chain fat), and sucrose monester fatty acid (a food grade surfactant) induce significant disruption of the intestinal barrier that causes leaky gut.<a href=\"#footnote_15_664\" id=\"identifier_20_664\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">15<\/a>.<\/li>\n<li style=\"text-align: justify\"><strong>Excessive Refined White Flours\u00a0<\/strong>(bran layer removed)<strong>.\u00a0<\/strong>Includes\u00a0products made from them such as cookies, bread, cakes, pies.\u00a0Bran contains the vitamins and minerals that metabolize grains and slows the otherwise rapid entry of sugar from their digestion into the bloodstream.\u00a0Also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_15_664\" id=\"identifier_21_664\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">15<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Refined Sugars.\u00a0<\/strong>\u00a0Includes white sugar, corn fructose and high fructose corn syrup.<\/li>\n<li style=\"text-align: justify\"><strong>Artificial sweeteners<\/strong>. Includes Aspartame, Sucralose, and Saccharin which are also linked to cancer and autoimmune disease.<\/li>\n<li style=\"text-align: justify\"><strong>Certain Spices<\/strong>. Includes paprika and cayenne pepper which disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_15_664\" id=\"identifier_22_664\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">15<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Alcohol and Caffeine<\/strong>. Disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_15_664\" id=\"identifier_23_664\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">15<\/a>\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Important Anti-Inflammatory Food Types to Promote Health<\/strong>:<\/p>\n<ul class=\"cp_bullet green\">\n<li style=\"text-align: justify\"><strong>Fruits<\/strong>.\u00a0Contain ample amounts of vitamins, minerals and phytochemicals which are\u00a0naturally occuring components in plants that detoxify toxins, carcinogens (reducing the risk by 50%) and mutagens.<\/li>\n<li style=\"text-align: justify\"><strong>Non-Starchy Vegetables.<\/strong>\u00a0Support intestinal integrity and provide ample amounts of vitamins, minerals and phytochemicals. Includes lettuce, kale, onion, broccoli, garlic, and others.<\/li>\n<li style=\"text-align: justify\"><strong>High Quality Complex Carbohydrates<\/strong>. Provide vitamins, minerals, and fiber while boosting serotonin levels to help you relax and feel calm. Includes whole grains, legumes, and root vegetables such as carrots, parsnips, sweet potatoes, turnips, red beets, and others.<\/li>\n<li style=\"text-align: justify\"><strong>Antioxidants<\/strong>. Protect the body from inflammatory oxidant molecules that continually occur and\u00a0help us handle stress and reduce irritability. Includes vitamin C-containing foods such as lemon, grapefruit, apricot, Brussels sprouts and strawberries, and others. Also, includes vitamin E-containing foods such as\u00a0nuts, seeds, avocado, olive oil, and others. Cocoa is good, too.<\/li>\n<li style=\"text-align: justify\"><strong>Omega-3 Fatty Acids<\/strong>. Balance opposing omega-6 fatty acids and bad fats. Fish sources includes tuna, salmon, cod, and others. Plants sources include flax, chia seeds, canola oil, and others.<\/li>\n<li style=\"text-align: justify\"><strong>Probiotics.\u00a0<\/strong>Supply normal microbes needed for colon health and health of the body such as these fermented foods: yogurt, kefir, and unpasteurized apple cider vinegar.<\/li>\n<li style=\"text-align: justify\"><strong>Prebiotics\/ High Fiber Foods<\/strong>. \u00a0Food with fiber keeps our population of colonic microbes healthy.<\/li>\n<li style=\"text-align: justify\"><strong>Protective Herbs and Spices<\/strong>. \u00a0See below #6 below for examples.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">3<\/span>\u00a0Information Sheet You Can Take to Your Doctor or Other Health Professional:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p>Click here.<\/p>\n<p>&nbsp;<\/p>\n<ul class=\"cp_check green\">\n<li><span style=\"color: #800000\"><strong><em><span class=\"dropcap\">4<\/span>\u00a0Manage Your Medications\u00a0Safely<\/em>:<\/strong><\/span><\/li>\n<\/ul>\n<div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">Certain prescription drugs used for depression cause nutritional deficiencies. Other drugs deplete these nutrients that cause depression: magnesium, potassium, niacin (vitamin B3), vitamin B12, pyridoxine (vitamin B6), vitamin C, zinc, and amino acids. Ask your doctor or pharmacist about this possible adverse effect if you are prescribed these drugs. <strong>Do not stop without supervision &#8211; this is mandatory<\/strong>):<\/p>\n<ul class=\"cp_bullet blue\">\n<li><strong>ANTI-DEPRESSANTS<\/strong>\n<ul>\n<li><em><em>Adapin\u00ae, Aventyl\u00ae, Elavil\u00ae, Pamelor\u00ae, and others <\/em><\/em>deplete these nutrients: Coenzyme Q10, Vitamin B12, Riboflavin.<em><em><br \/>\n<\/em><\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Caution<em>:\u00a0<\/em><\/strong><em>If you are taking anti-depression drugs, before trying herbals, such St. John\u2019s wort, discuss with a\u00a0licensed health care professional because they can have an additive effect if taken at the same time.<a href=\"#footnote_16_664\" id=\"identifier_24_664\" class=\"footnote-link footnote-identifier-link\" title=\"http:\/\/www.pharmacistelink.com\/naturalmedicine\/pdfs\/P4880x1204DrugChart.pdf\">16<\/a><\/em><\/p>\n<p><strong>ANTACIDS \/ ULCER MEDICATIONS<\/strong><\/p>\n<ul class=\"cp_bullet blue\">\n<li style=\"text-align: justify\">Pepcid\u00ae, Tagamet\u00ae, Zantac\u00ae deplete Vitamin B12, Zinc, Magnesium, Potassium.<\/li>\n<li style=\"text-align: justify\">Magnesium and Aluminum Antacid preparations (Gaviscon\u00ae, Maalox\u00ae, Mylanta\u00ae) deplete\u00a0Vitamin B12, Zinc, Magnesium, Potassium.<\/li>\n<li style=\"text-align: justify\">Prevacid\u00ae, Prilosec\u00ae\u00a0deplete Vitamin B12.<\/li>\n<li style=\"text-align: justify\">Alka Seltzer\u00ae, Baking Soda deplete Magnesium, Proteins, Potassium.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTIBIOTICS\u00a0<\/strong>disrupt intestinal permeability which complicates celiac disease.<\/p>\n<ul class=\"cp_bullet blue\">\n<li style=\"text-align: justify\">Gentomycin, Neomycin, Streptomycin, Cephalosporins, Penicillins\u00a0deplete\u00a0B Vitamins, Vitamin C.<\/li>\n<li style=\"text-align: justify\">\u00a0Tetracyclines deplete Magnesium,Vitamin B6, Zinc.<\/li>\n<li style=\"text-align: justify\">Cipro depletes Zinc.<\/li>\n<\/ul>\n<p><strong>ANTI-INFLAMMATORIES<\/strong>\u00a0disrupt intestinal permeability which complicates celiac disease.<\/p>\n<ul class=\"cp_bullet blue\">\n<li style=\"text-align: justify\">Corticosteroids (Prednisone, Medrol\u00ae, Aristocort\u00ae, Decadron) deplete Magnesium, Zinc, Vitamin C, Vitamin B6, Vitamin B12.<\/li>\n<li style=\"text-align: justify\">Aspirin and Salicylates deplete Vitamin C.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTICONVULSANTS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Phenobarbital and Barbituates; and Dilantin\u00ae, Tegretol\u00ae, Mysoline\u00ae, Depakane\/Depacon\u00ae deplete Carnitine, Vitamin B12, Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>ANTIVIRAL AGENTS<\/strong><\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Zidovudine (Retrovir\u00ae, AZT and other related drugs) deplete Carnitine, Zinc, Vitamin B12.<\/li>\n<li>Foscanet depletesMagnesium, Potassium.<strong>\u00a0<\/strong><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>CARDIOVASCULAR DRUGS<\/strong><\/p>\n<ul class=\"cp_bullet blue\">\n<li style=\"text-align: justify\">Antihypertensives (Catapres\u00ae, Aldomet) deplete Vitamin B6, Zinc.<\/li>\n<li style=\"text-align: justify\">ACE Inhibitors\u00a0<em>(Capoten<em>\u00ae<\/em>, Vasotec\u00ae, Monopril\u00ae and others) deplete Zinc.<\/em><\/li>\n<\/ul>\n<p><strong>CHOLESTEROL DRUGS<\/strong><\/p>\n<ul class=\"cp_bullet blue\">\n<li>Colestid\u00ae and Questran\u00ae deplete Vitamin B12.<\/li>\n<\/ul>\n<p><strong>DIABETIC DRUGS\u00a0<\/strong><\/p>\n<ul class=\"cp_bullet blue\">\n<li>Metformin\u00ae depletes Vitamin B12.<\/li>\n<\/ul>\n<p><strong>DIURETICS<\/strong><\/p>\n<ul class=\"cp_bullet blue\">\n<li style=\"text-align: justify\">Thiazide Diuretics (Hydrochlorothiazide, Enduron\u00ae, Diuril\u00ae, Lozol\u00ae, Zaroxolyn\u00ae, Hygroton\u00ae and others) deplete Potassium, Magnesium, Zinc.<\/li>\n<li style=\"text-align: justify\">Loop Diuretics (Lasix\u00ae, Bumex\u00ae, Edecrin\u00ae) depletes Magnesium, Vitamin B6, Vitamin C, Potassium, Zinc.<\/li>\n<li style=\"text-align: justify\">Potassium Sparing Diuretics (Midamor\u00ae, Aldactone\u00ae, Dyrenium\u00ae and others) deplete Zinc.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>FEMALE HORMONES<\/strong>\u00a0disrupt intestinal permeability which complicate celiac disease.<\/p>\n<ul class=\"cp_bullet blue\">\n<li style=\"text-align: justify\">Oral Contraceptives (Norinyl\u00ae, Ortho-Novum\u00ae, Triphasil\u00ae, and others) deplete Vitamin B3, Vitamin B6, Vitamin B12, Vitamin C, Magnesium.\u00a0Correlation analysis shows significant association between some trace elements and the duration of contraception and body mass index of the study participants.<a href=\"#footnote_17_664\" id=\"identifier_25_664\" class=\"footnote-link footnote-identifier-link\" title=\"Akinloye O1, Adebayo TO, Oguntibeju OO, Oparinde DP, Ogunyemi EO. Effects of contraceptives on serum trace elements, calcium and phosphorus levels. West Indian Med J. 2011 Jun;60(3):308-15.\">17<\/a><\/li>\n<li style=\"text-align: justify\">Oral Estrogen\/Hormone Replacement (Evista\u00ae, Prempro\u00ae, Premarin\u00ae, Estratab\u00ae and others) deplete Vitamin B6, Vitamin B12, Vitamin C, Magnesium, Zinc.<\/li>\n<\/ul>\n<p><strong>MAJOR TRANQUILIZERS<\/strong>\u00a0<strong>\u00a0<\/strong><\/p>\n<ul class=\"cp_bullet blue\">\n<li>Thorazine\u00ae, Mellaril\u00ae, Prolixin\u00ae, Serentil\u00ae and others\u00a0deplete\u00a0Coenzyme Q10, Vitamin B12.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">5<\/span>Nutritional Supplements To Help Correct Deficiencies:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">The type and quantity of nutritional supplements that may be needed depend on which nutrients are deficient.<\/p>\n<ul class=\"cp_bullet orange\">\n<li style=\"text-align: justify\">Multivitamin\/mineral combination once a day is useful to improve overall nutrient levels. This is a safe dose, but always check with your doctor to avoid interactions with medications.<\/li>\n<li style=\"text-align: justify\">100% of the B vitamins, or as prescribed by a doctor. About\u00a0B Vitamin Complex supplements: \u00a0some labeling can be confusing, for example, &#8220;B 100&#8221; does not mean 100%. If the ingredient list shows\u00a0\u00a0an excessive amount like\u00a03000% or more, look for another brand because this excessive amount will cause the loss of mineral in the urine.<\/li>\n<li style=\"text-align: justify\">Chelated Magnesium as prescribed.<\/li>\n<li style=\"text-align: justify\">Potassium as prescribed following bloodwork first.<\/li>\n<\/ul>\n<p><strong>Storage Note<\/strong>:\u00a0<em>Store container tightly sealed, away from heat, moisture and direct light to avoid loss of potency. That is, in a safe kitchen cabinet &#8211; not in the bathroom or on the kitchen table<\/em>.\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\">\n<li><span style=\"color: #800000\"><em><strong><span class=\"dropcap\">6<\/span>Manage Natural Remedies:\u00a0<\/strong><\/em><\/span><\/li>\n<\/ul>\n<div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Hydration<\/strong>:<\/p>\n<ul class=\"cp_bullet green\">\n<li style=\"text-align: justify\">Eight glasses of water are recommended per day unless there is a contraindication such as kidney or heart disease. The Institute of Medicine recommends approximately 2.7 liters (91 ounces) of total water, from all beverages and foods, each day for women and 3.7 liters (125 ounces) daily of total water for men.<\/li>\n<li style=\"text-align: justify\">If you are thirsty, drink water. Add fresh, squeezed lemon to water. Lemon is anti-inflammatory, alkalizing and provides vitamin C.<\/li>\n<li style=\"text-align: justify\">Hydration Test: Urine should be pale yellow. Fingertips should be plump, without pruning but this may not be reliable when fingers are swollen with edema. Lips should be plump, without puckering. The feeling of thirst can be unreliable.<\/li>\n<li style=\"text-align: justify\">What is wrong with soda, coffee, tea, and alcohol? These drinks are dehydrating, increase acid, and deplete nutrients.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Carminatives.\u00a0<\/strong>The following \u00a0anti-inflammatory\u00a0plant sources called carminitives help heal the digestive tract. They also tone the digestive muscles which improves peristalsis, thus aiding in the expulsion of gas from the stomach and intestine to relieve digestive colic and gastric discomfort which are often part of chronic anxiety.<\/p>\n<p style=\"text-align: justify\"><strong>Carminative Food Remedies<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Raspberry.<\/li>\n<li>Carrot is also a cleansing digestive tonic.<\/li>\n<li>Grape is also bile stimulating and a cleansing remedy for sluggish digestion and laxative.<\/li>\n<li>Redbeets also stimulate and improve digestion and are easily digested.<\/li>\n<li>Cabbage also stimulates and improves digestion and is also a liver decongestant.<\/li>\n<li>Lettuce also stimulates and improves digestion and is also an alterative, meaning it improves the function of organs involved with the digestion and excretion of waste products to bring about a gradual change.<\/li>\n<li>Potatoes are antispasmodic (due to atropine like properties) and a liver remedy.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Herb Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\">\n<li style=\"text-align: justify\">Sage is also a digestive, astringent, bile stimulant and energy tonic that heals the mucosa. \u00a0Drink as tea or use in cooking.<\/li>\n<li>Chamomile, lemon balm, and fennel, (as a tea) also help relieve nervous tension.<\/li>\n<li>Parsley also relieves indigestion.<\/li>\n<li>Rosemary as a tea and in cooking also is a nervous system tonic for stress and fatigue, bile stimulant, and can relieve headaches and indigestion.<\/li>\n<li>Thyme is also soothing remedy useful for stimulating digestion of rich, fatty foods.<\/li>\n<\/ul>\n<p><strong>Carminative Spice Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\">\n<li>Cloves are also antispasmodic.<\/li>\n<li>Nutmeg is also useful for indigestion.<\/li>\n<li>Ginger.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Exercise Helps<\/strong>:<\/p>\n<p>Exercise stimulates the brain to produce anti-depressive chemicals and get rid of stress hormones.<\/p>\n<ul class=\"cp_bullet green\">\n<li>Walking is aerobic exercise that reconditions the whole body to improve stamina.\u00a0Read more about<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">\u00a0Exercise and Fitness<\/a>.<\/li>\n<li>Weight training builds muscle.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<li>Stretching improves flexibilty.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<\/ul>\n<p><strong>Note<\/strong>: Exercise is important, but the amount and type of exercise undertaken depends on your health. Your first priority is to heal. \n\t\t\t<\/div><\/div>\n<h2>What Do Medical Research Studies Tell About Depression\u00a0In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<h4><span style=\"color: #000000\"><strong>RESEARCH STUDY SUMMARIES<\/strong><\/span><\/h4>\n<p style=\"text-align: justify\"><strong>&#8220;Factors influencing the type, timing and severity of symptomatic responses to dietary gluten in patients with biopsy-proven coeliac disease.&#8221;<\/strong> This study investigating the type, timing and severity of symptomatic responses (SRDG) to dietary gluten with reference to a range of\u00a0disease-related factors found that patients with consistent gluten free diet adherence experience a SRDG faster and more severe in comparison to prior gluten exposure possibly demonstrating an adept immunological response. Anxiety and depression also enhance the speed of symptom onset and co-existing visceral hypersensitivity is a risk factor for severe reactions to dietary gluten.<\/p>\n<p style=\"text-align: justify\">Method of study: Postal survey of 224 biopsy-proven patients including gluten-free diet adherence, symptom checklist, ROME II criteria and The Hospital Anxiety &amp; Depression Scale. Case-note review was also conducted.<\/p>\n<p style=\"text-align: justify\">26% of respondents were male. Full gluten free diet adherence numbered 159 (70%). Irritable bowel syndrome (IBS) numbered 50 (22%). Anxiety numbered 30 (13%); Depression numbered 33 (14%); Anxiety &amp; Depression numbered 72 (32%).\u00a0Pruritus, fatigue and bloating were a more common SRDG in the partial\/none gluten free diet adherent group. Co-existing IBS was associated with a greater prevalence of nausea and fatigue in response to gluten.<\/p>\n<p style=\"text-align: justify\">Fully gluten free diet adherent patients are more likely to have SRDG less than 1hr than partial\/none adherent as are a third of patients with co-existing IBS and those patients at risk of both anxiety and depression. Inadvertent exposure to dietary gluten in the fully gluten free diet adherent group is more likely to result in a severe SRDG in comparison to symptoms arising prior to consistent gluten free diet adherence.<a href=\"#footnote_7_664\" id=\"identifier_26_664\" class=\"footnote-link footnote-identifier-link\" title=\"Barratt SM, Leeds JS, Sanders DS. Factors influencing the type, timing and severity of symptomatic responses to dietary gluten in patients with biopsy-proven coeliac disease. J Gastrointestin Liver Dis. 2013 Dec;22(4):391-6.\">7<\/a><\/p>\n<p style=\"text-align: justify\">&#8220;<strong>Fatigue in adult coeliac disease<\/strong>.&#8221; This study evaluating the prevalence, characteristics and associations of fatigue in adult celiac disease patients found that fatigue is a common finding, which ameliorates with the gluten-free diet and is strictly correlated to depression.<\/p>\n<p style=\"text-align: justify\">A total of 130 coeliac disease patients were consecutively recruited in both treated (59 on gluten-free diet) and untreated conditions (71 on normal diet). The control group was made up of 80 healthy controls. Celiac disease patients and healthy controls underwent laboratory tests, a set of questionnaires for studying fatigue: visual analogue scale for fatigue,chronic fatigue syndrome questionnaire, fatigue severity scale and a modified version of the Zung self-rating depression scale.<\/p>\n<p style=\"text-align: justify\">RESULTS: Celiac disease patients showed a significantly lower body mass index than controls and lower serum iron. The entire cohort of celiac disease patients reported greater modified version of the Zung self-rating depression scale score, greater visual analogue scale for fatigue score and greater chronic fatigue syndrome questionnaire score compared with healthy controls. Celiac disease patients on a gluten-free diet had a significantly higher modified version of the Zung self-rating depression scale score than celiacs on a normal diet. The prevalence of pathological modified version of the Zung self-rating depression scale score was 17% in all celiac disease patients and 0% in healthy controls. A significant correlation was found between modified version of the Zung self-rating depression scale score and fatigue scale scores in celiacs on a normal diet. Presence\/absence of gastrointestinal symptoms did not show any significant correlation with modified version of the Zung self-rating depression scale score and fatigue scale scores.<a href=\"#footnote_18_664\" id=\"identifier_27_664\" class=\"footnote-link footnote-identifier-link\" title=\"Siniscalchi M1, Iovino P, Tortora R, Forestiero S, Somma A, Capuano L, Franzese MD, Sabbatini F, Ciacci C. Fatigue in adult coeliac disease. Aliment Pharmacol Ther. 2005 Sep 1;22(5):489-94.\">18<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cRegional cerebral hypoperfusion in patients with celiac disease.\u201d<\/strong> This study\u00a0evaluating cerebral perfusion in untreated Celiac Disease patients demonstrated evidence of regional cerebral blood flow alteration. 73% had at least one hypoperfused brain area vs. 7% of patients on a Gluten Free Diet and none of controls.<a href=\"#footnote_11_664\" id=\"identifier_28_664\" class=\"footnote-link footnote-identifier-link\" title=\"Addolorato G, Di Giuda D, De Rossi G, et al. Regional cerebral hypoperfusion in patients with celiac disease.&nbsp;American Journal of Medicine. Mar 1, 2004;116(5):312-7.\">11<\/a><\/p>\n<p style=\"text-align: justify\"><b>\u201cClinical and neurological abnormalities in adult celiac disease.\u201d<\/b> This study investigating the occurrence of neurological signs and symptoms in adult patients with\u00a0celiac disease\u00a0and the correlation between neurological features and diet found that neurological signs and symptoms are associated with\u00a0celiac disease\u00a0and can be ameliorated by a gluten-free diet. A total of 176 patients and 52 age-matched controls underwent a semistructural interview and a neurologic examination. The effect of gluten-free diet was evaluated by comparing the prevalence of signs and symptoms among patients adhering to a gluten-free diet and patients on an unrestricted diet.<\/p>\n<p style=\"text-align: justify\">The occurrence of headache, dysthymia (mild depression) and signs of peripheral neuropathy was significantly higher in patients with\u00a0celiac disease\u00a0than in control subjects. Adherence to a strict gluten-free diet was associated with a significant reduction of headache, dysthymia, cramps and\u00a0weakness, but did not modify the occurrence of paresthesia or hyporeflexia. Neurological signs and symptoms are associated with\u00a0celiac disease\u00a0and can be ameliorated by a gluten-free diet.<a href=\"#footnote_19_664\" id=\"identifier_29_664\" class=\"footnote-link footnote-identifier-link\" title=\"Cicarelli G, Della Rocca G, Amboni M, Ciacci C, Mazzacca G, Filla A, Barone P. Clinical and neurological abnormalities in adult celiac disease. Neurol Sci. 2003 Dec;24(5):311-7.\">19<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cAnxiety but not depression decreases in coeliac patients after one-year gluten-free diet: a longitudinal study.\u201d<\/strong> This study evaluating the real nature of depression in classic Celiac Disease patients at diagnosis and 1 year follow-up using the State and Trait Inventory test demonstrated treatment after 1 year on a Gluten Free Diet failed to reduce depression in a significant percentage of patients. Results could suggest patients need psychological support.<a href=\"#footnote_20_664\" id=\"identifier_30_664\" class=\"footnote-link footnote-identifier-link\" title=\"Addolorato G, Capristo E, Ghittoni G, et al. Anxiety but not depression decreases in coeliac patients after one-year gluten-free diet: a longitudinal study. Scandanavian Journal of Gastroenterology. May 2001;36(5):502-6.\">20<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cReversal of psychopathology in adult celiac disease with the aid of pyridoxine (vitamin B6).\u201d<\/strong> This study using the Minnesota Multiphasic Personality Inventory\u00a0(MMPI) to evaluate response to Gluten Free Diet of newly diagnosed patients demonstrated no improvement after one year despite improved intestinal mucosa. After 3 years, following 6 months of\u00a080mg\/day of oral pyridoxine therapy, scores became normalized indicating a causal relationship between adult celiac disease and concomitant depressive symptoms and implicating metabolic effects from pyridoxine deficiency.<a href=\"#footnote_3_664\" id=\"identifier_31_664\" class=\"footnote-link footnote-identifier-link\" title=\"Hallert C, Astrom J, Walan A. Reversal of psychopathology in adult coeliac disease with the aid of pyridoxine (vitamin B6). Scandanavian Journal of Gastroenterology. Mar 1983;18(2):299-304.\">3<\/a><\/p>\n<p style=\"text-align: justify\"><strong>Psychic disturbances in adult coeliac disease.\u201d<\/strong> This study evaluating personality using the Minnesota Multiphasic Personality Inventory (MMPI) demonstated high score for depression. The score correlated with daily fat excretion but was unrelated to gastrointestinal complaints. Depression is a feature of adult Celiac Disease.<a href=\"#footnote_21_664\" id=\"identifier_32_664\" class=\"footnote-link footnote-identifier-link\" title=\"Hallert C, Astrom J. Psychic disturbances in adult coeliac disease. II. Psychological findings. Scandanavian Journal of Gastroenterology. Jan 1982;17(1):21-4.\">21<\/a><\/p>\n<h4 style=\"text-align: justify\"><span style=\"color: #000000\"><strong>CASE REPORT SUMMARIES<\/strong><\/span><\/h4>\n<p style=\"text-align: justify\"><strong>&#8220;Neuropsychiatric symptoms and celiac disease.&#8221;<\/strong> This case report describes diagnosis of celiac disease in a patient suffering from chronic, treatment-resistant symptoms of depression and anxiety. The diagnosis of celiac disease and introduction of an elimination diet caused a significant improvement in mental state and everyday functioning in the presenting patient.<\/p>\n<p style=\"text-align: justify\">The reporting physicians state, &#8220;The presence of persistent anxiety and depressive symptoms, with a poor reaction to pharmacological treatment, indicates a need to identify somatic reasons for the underlying condition. It is important to remember that celiac disease can occur at any age, not only in childhood. The presence of this somatic cause of persistent depressive and anxiety symptoms should be considered in the diagnostic process in adults.<a href=\"#footnote_22_664\" id=\"identifier_33_664\" class=\"footnote-link footnote-identifier-link\" title=\"Urban-Kowalczyk M, OEmigielski J, Gmitrowicz A. Neuropsychiatric symptoms and celiac disease. Neuropsychiatr Dis Treat. 2014 Oct 14;10:1961-4. doi: 10.2147\/NDT.S69039. eCollection 2014.\">22<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cPsychosis revealing a silent celiac disease in a young woman with trisomy 21.\u201d<\/strong> Thus case report describes depression related to Celiac Disease in a patient, age 41, with Down&#8217;s syndrome who showed spectacular and lasting improvement of both psychotic and depressive symptoms obtained after 12 months on a Gluten Free Diet.<a href=\"#footnote_23_664\" id=\"identifier_34_664\" class=\"footnote-link footnote-identifier-link\" title=\"Serratrice J, Disdier P, Kaladjian A, et al. Psychosis revealing a silent celiac disease in a young woman with trisomy 21.La Presse Medicale. Oct 12, 2002;31(33):1551-3.\">23<\/a><\/p>\n<p style=\"text-align: justify\">\n<ol class=\"footnotes\"><li id=\"footnote_1_664\" class=\"footnote\">Potocki P, Hozyasz K. Psychiatric symptoms and coeliac disease. <em>Psychiatria Polska<\/em>. Jul-Aug 2002;36(4):567-78. <span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_664\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_2_664\" class=\"footnote\">Eby GA 3rd, Eby KL. Magnesium for treatment-resistant depression: a review and hypothesis. Med Hypotheses. 2010 Apr;74(4):649-60. doi: 10.1016\/j.mehy.2009.10.051.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_2_664\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_3_664\" class=\"footnote\">Hallert C, Astrom J, Walan A. Reversal of psychopathology in adult coeliac disease with the aid of pyridoxine (vitamin B6). <em>Scandanavian Journal of Gastroenterology<\/em>. Mar 1983;18(2):299-304.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_3_664\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_9_664\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_31_664\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_4_664\" class=\"footnote\">Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F. 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Jan 1982;17(1):21-4.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_32_664\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_22_664\" class=\"footnote\">Urban-Kowalczyk M, OEmigielski J, Gmitrowicz A. Neuropsychiatric symptoms and celiac disease. <em>Neuropsychiatr Dis Treat<\/em>. 2014 Oct 14;10:1961-4. doi: 10.2147\/NDT.S69039. eCollection 2014.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_33_664\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_23_664\" class=\"footnote\">Serratrice J, Disdier P, Kaladjian A, et al. Psychosis revealing a silent celiac disease in a young woman with trisomy 21.<em>La Presse Medicale<\/em>. Oct 12, 2002;31(33):1551-3.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_34_664\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>What Is Depression? Depression is a mood disorder characterized by absence of cheerfulness, dejection, and loss of interest or pleasure in living, making the person dysfunctional and unable to cope with or perform tasks of daily living. More than a feeling, this negative psychological status can range from mild to profound\u00a0and can involve other parts &#8230;<\/p>\n","protected":false},"author":29,"featured_media":8579,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4,139,144,105,117,1682,200,112,782,49,199,203,127,107,122,126,109],"tags":[1059,1926,470,1672,202,1085,327,1084,1083,1904,452,776,382,384,1912,1961,1674,1086,1909,1673,1082,1056,1887,1962,1905,1920,1907],"class_list":["post-664","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-conditions-2","category-b-vitamins","category-brain","category-folic-acid","category-magnesium","category-malabsorption-disorders","category-mind","category-protein","category-atypical-symptom","category-nervous-2","category-tryptophan","category-tyrosine","category-thiamin","category-vitamin-b12","category-pyridoxine","category-vitamin-c","category-zinc","tag-atypical","tag-brain","tag-depression","tag-epa-eicosapentaenoic-acid","tag-especially-tryptophan","tag-excessive-sleep","tag-fatigue","tag-feelings-of-guilt","tag-feelings-of-worthlessness","tag-folic-acid","tag-headache","tag-health-conditions","tag-insomnia","tag-irritability","tag-magnesium","tag-mind","tag-niacin-vitamin-b3","tag-poor-concentration","tag-protein","tag-pyridoxine-vitamin-b6","tag-suicidal-thoughts","tag-symptoms-2","tag-nervous-2","tag-tyrosine","tag-vitamin-b12","tag-vitamin-c","tag-zinc"],"_links":{"self":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/comments?post=664"}],"version-history":[{"count":58,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/664\/revisions"}],"predecessor-version":[{"id":8582,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/664\/revisions\/8582"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media\/8579"}],"wp:attachment":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media?parent=664"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/categories?post=664"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/tags?post=664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}