{"id":471,"date":"2013-04-24T14:26:54","date_gmt":"2013-04-24T18:26:54","guid":{"rendered":"http:\/\/www.mynutriguide.com\/?p=471"},"modified":"2019-12-26T12:45:34","modified_gmt":"2019-12-26T17:45:34","slug":"common-variable-immunodeficiency-3","status":"publish","type":"post","link":"https:\/\/glutenfreeworks.com\/health\/common-variable-immunodeficiency-3\/","title":{"rendered":"Common Variable Immunodeficiency\u00a0"},"content":{"rendered":"
\"Depiction<\/a>

Depiction of an antibody. Courtesy NIH<\/em><\/p><\/div>\n

What Is Common Variable Immunodeficiency?<\/h2>\n

C<\/span>ommon variable immunodeficiency (CVID) is a primary antibody deficiency<\/span>\u00a0disease characterized by the onset of recurrent bacterial infections resulting from markedly decreased immunoglobulin antibody production and antibody levels.<\/p>\n

Q<\/strong>: What causes common variable immunodeficiency?<\/p>\n

A<\/strong>:\u00a0Common variable immunodeficiency is\u00a0caused by a defect in any critical stage of B cell development and is characterized by impaired production of normal amounts of antigen-specific antibodies. This is a set up for infection, autoimmune disease, and cancer.<\/p>\n

One important histologic feature is the absence or paucity of plasma cells in the biopsy that occurs in common variable immunodeficiency. The diagnosis is initially made by measuring quantitative immunoglobulins and then specific immune testing on these cell subsets in the circulation by flow cytometry.1<\/a><\/p>\n

Early diagnosis and treatment with IgG therapy (immunoglobulin G) can decrease illness and mortality.2<\/a>\u00a0<\/span><\/p>\n

Pulmonary damage is the most frequent complication and may result from recurrent infections and\/or immune dysregulation. Other complications due to the underlying immune dysregulation include lymphoproliferative disease (granulomatous disease, lymphadenopathy and hepatosplenomegaly), autoimmune disease, gastrointestinal disease such as chronic inflammation and an increased risk of cancer.3<\/a><\/span><\/p>\n

It is important to recognize that common variable immunodeficiency can occur at any age, but an early onset may be associated with an increased risk of gastric cancers and lymphoma, particularly of the intestine.3<\/a><\/p>\n

Patients with common variable immunodeficiency should be managed by an immunologist with experience in primary immunodeficiency states, given the complications of these patients.4<\/a><\/p>\n

What Is Common Variable Immunodeficiency In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n

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