{"id":457,"date":"2013-01-01T14:22:52","date_gmt":"2013-01-01T19:22:52","guid":{"rendered":"http:\/\/www.mynutriguide.com\/?p=457"},"modified":"2019-12-26T13:14:39","modified_gmt":"2019-12-26T18:14:39","slug":"hyperthyroidism-graves-disease-4","status":"publish","type":"post","link":"https:\/\/glutenfreeworks.com\/health\/hyperthyroidism-graves-disease-4\/","title":{"rendered":"Hyperthyroidism &#8211; Grave&#8217;s Disease\u00a0"},"content":{"rendered":"<div id=\"attachment_3348\" style=\"width: 310px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/Graves-Proptosis_and_lid_retraction_from_Graves_Disease-wikimedia.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-3348\" class=\"size-full wp-image-3348\" src=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/Graves-Proptosis_and_lid_retraction_from_Graves_Disease-wikimedia.jpg\" alt=\"Proptosis and lid retraction are features of  Grave's disease, or hyperthyroidism. Courtesy of Wikimedia.\" width=\"300\" height=\"198\" \/><\/a><p id=\"caption-attachment-3348\" class=\"wp-caption-text\">Proptosis and Lid Retraction are Features of Grave&#8217;s Disease, or Hyperthyroidism. <em><br \/><\/em><\/p><\/div>\n<h2>What Is Grave&#8217;s Disease (Hyperthyroidism)?<\/h2>\n<p style=\"text-align: justify\"><span class=\"dropcap\">G<\/span>rave&#8217;s disease, or hyperthyroidism, is an autoimmune thyroid disease characterized by diffuse nontender goiter, elevated thyroxine hormone levels (T4, T3), suppressed thyroid stimulating hormone (TSH), and presence of thyroid receptor antibodies in the blood.<\/p>\n<p style=\"text-align: justify\">The autoantibodies involved are anti-thyroid peroxidase and anti-thyroglobulin antibodies. They bind to the thyroid stimulating hormone receptors, causing thyroid stimulation. These antibodies are detected by blood tests.<\/p>\n<p><strong>Q<\/strong>: What happens to the thyroid gland in Grave&#8217;s disease?<\/p>\n<p style=\"text-align: justify\"><strong>A<\/strong>: The thyroid gland is located in the front of the neck. This butterfly shaped gland consists of a large number of closed vesicles that contain a homogenous substance called colloid, which contains the thyroglobulin. Thyroglobulin is an iodine-containing protein secreted by the thyroid gland and stored within its colloid, from which the thyroid hormones thyroxine (T4) and triiodothyroinine (T3) are derived.<a href=\"#footnote_1_457\" id=\"identifier_1_457\" class=\"footnote-link footnote-identifier-link\" title=\"Taber&rsquo;s Cyclopedic Medical Dictionary. 19th ed. F.A. Davis Company. Philadelphia, PA.\">1<\/a><\/p>\n<div id=\"attachment_12997\" style=\"width: 202px\" class=\"wp-caption alignright\"><a href=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/canstockphoto15923395.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-12997\" class=\" wp-image-12997\" src=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/canstockphoto15923395-300x225.jpg\" alt=\"Thyroxine molecule, chemical structure. Thyroid gland hormone that plays a role in energy metabolism regulation. It is a iodine containing derivative of thyrosine. Atoms are represented as spheres with conventional color coding: hydrogen (white), carbon (grey), oxygen (red), nitrogen (blue), iodine (purple).\" width=\"192\" height=\"144\" srcset=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/canstockphoto15923395-300x225.jpg 300w, https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/canstockphoto15923395.jpg 800w\" sizes=\"auto, (max-width: 192px) 100vw, 192px\" \/><\/a><p id=\"caption-attachment-12997\" class=\"wp-caption-text\">Thyroxine molecule. Atoms are represented as spheres with conventional color coding: hydrogen (white), carbon (grey), oxygen (red), nitrogen (blue), iodine (purple).<\/p><\/div>\n<p style=\"text-align: justify\">T3 is the active hormone and is made from T4. Thyroid hormones are released into the bloodstream as needed to control metabolism, brain development, breathing, heart and nervous system functions, body temperature, muscle strength, skin dryness, menstrual cycles, weight, and cholesterol levels.<\/p>\n<p style=\"text-align: justify\">Thyroid hormone production is regulated by thyroid-stimulating hormone (TSH), which is made by the pituitary gland in the brain. Normally, when thyroid hormone levels in the blood are low, the pituitary releases more TSH in response to stimulation by the nearby hypothalamus which is continually monitoring levels of thyroxin. When thyroid hormone levels are high, the pituitary decreases TSH production. So in Grave&#8217;s disease, release of TSH by the pituitary gland is suppressed by the hypothalamus because thyroid hormone is elevated. Goiter develops from growth stimulation by thyroid stimulating autoantibodies.<\/p>\n<h2>What Is Grave&#8217;s Disease In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p><!--more--><\/p>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\"><strong>Relationship between \u00a0Grave&#8217;s disease and celiac disease<\/strong>: Grave&#8217;s disease is an associated immune disorder in celiac disease.<\/li>\n<li style=\"text-align: justify\"><strong>Relationship between \u00a0Grave&#8217;s disease and antibody tests.\u00a0<\/strong>Screening of 111 consecutive patients with Grave&#8217;s hyperthyroidism revealed anti-gliadin antibodies in 14%, anti-tissue transglutaminase antibodies in 2% and IgA deficiency in 3%.<a href=\"#footnote_2_457\" id=\"identifier_2_457\" class=\"footnote-link footnote-identifier-link\" title=\"Ch&rsquo;ng CL, Biswas M, Jones MK, Kingham JG. Prospective screening for celiac disease in patients with Grave&rsquo;s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies.&nbsp;Clinical Endocrinology. Mar. 2005; 62:303-6.\">2<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Relationship between \u00a0Grave&#8217;s disease and genetics.\u00a0<\/strong>The association between celiac disease and other immune disorders may be due to the sharing of a common genetic background, such as HLA antigens. However, in a very large study, involving 909 patients with celiac disease, Ventura and his associates found that the development of immune disorders in celiac disease was clearly related to the duration of exposure to gluten.<a href=\"#footnote_3_457\" id=\"identifier_3_457\" class=\"footnote-link footnote-identifier-link\" title=\"La Villa G, Pantaleo P, Tarquini R, Cirami L, Perfetto F, Mancuso F, Laffi G. Multiple immune disorders in unrecognized celiac disease: a case report. World J Gastroenterol. 2003;9(6):1377-1380.\">3<\/a><\/li>\n<li style=\"text-align: justify\"><strong>Relationship between \u00a0Grave&#8217;s disease and autoimmune disease.\u00a0<\/strong>A large cross-sectional study investigating the prevalence of autoimmune co-morbidity in patients with autoimmune thyroid disease with and without thyroid-associated orbitopathy (TAO) found that in patients with TAO, celiac disease is the most prevalent co-morbid autoimmune condition and rates are increased compared to Grave\u2019s disease patients without TAO.<a href=\"#footnote_4_457\" id=\"identifier_4_457\" class=\"footnote-link footnote-identifier-link\" title=\"Ponto K, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T, Pitz S, Pfeiffer N, Kahaly G. Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. Clin Exp Immunol. 2014 Jun 5. doi: 10.1111\/cei.12395.\">4<\/a><\/li>\n<\/ul>\n<h2 style=\"text-align: justify\">How Prevalent Is Grave&#8217;s Disease In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<p style=\"text-align: justify\">Prevalence of celiac disease in patients with Grave&#8217;s disease is 4.5% compared with 0.9% in matched healthy controls.<a href=\"#footnote_5_457\" id=\"identifier_5_457\" class=\"footnote-link footnote-identifier-link\" title=\"Ch&rsquo;ng CL, Biswas M, Jones MK, Kingham JG. Prospective screening for celiac disease in patients with Grave&rsquo;s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies. Clinical Endocrinology. Mar. 2005; 62:303-6.\">5<\/a><\/p>\n<h2>What Are The Symptoms Of Grave&#8217;s Disease?<\/h2>\n<div id=\"attachment_3347\" style=\"width: 220px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/Graves-goiter-Struma_001-wikimedia.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-3347\" class=\" wp-image-3347 \" style=\"margin-left: 5px;margin-right: 5px\" src=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/Graves-goiter-Struma_001-wikimedia-300x224.jpg\" alt=\"Goiter in Grave's disease. Courtesy Wikimedia.\" width=\"210\" height=\"157\" srcset=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/Graves-goiter-Struma_001-wikimedia-300x224.jpg 300w, https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/Graves-goiter-Struma_001-wikimedia.jpg 800w\" sizes=\"auto, (max-width: 210px) 100vw, 210px\" \/><\/a><p id=\"caption-attachment-3347\" class=\"wp-caption-text\">Goiter in Grave&#8217;s Disease.<\/p><\/div>\n<p style=\"text-align: justify\">Grave&#8217;s disease is marked by these symptoms:<\/p>\n<ul class=\"cp_bullet red\">\n<ul>\n<ul>\n<li>Diffuse nontender goiter.<\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Proptosis (bulging of the eyes).\u00a0<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Pretibial myxedema (firm swelling of lower leg tissue) in most patients.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Rapid pulse.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Staring\u00a0<\/span><span style=\"text-align: justify\">due to inflammation of eye muscles (myositis).<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Increased blood pressure.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Palpitations.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Nervousness.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Depression.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Anxiety.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Heat intolerance.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Weight loss.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Proximal muscle weakness (thighs and upper arms).<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Brisk tendon reflexes.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Cardiac abnormalities.<\/span><\/li>\n<li><span style=\"text-align: justify;font-size: 14px;line-height: 1.5em\">Oligomenorrhea in females.<\/span><\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<h2>How Does Grave&#8217;s Disease Develop In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<ul class=\"cp_check red\">\n<li style=\"text-align: justify\">\n<div id=\"attachment_13002\" style=\"width: 187px\" class=\"wp-caption alignright\"><a href=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/canstockphoto18489185.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-13002\" class=\" wp-image-13002\" src=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/canstockphoto18489185-300x225.jpg\" alt=\"Chemical structure of a triiodothyronine (T3) molecule, thyroid hormone that affects growth and development, metabolism, body temperature, and heart rate.\" width=\"177\" height=\"133\" srcset=\"https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/canstockphoto18489185-300x225.jpg 300w, https:\/\/glutenfreeworks.com\/health\/wp-content\/uploads\/sites\/10\/canstockphoto18489185.jpg 800w\" sizes=\"auto, (max-width: 177px) 100vw, 177px\" \/><\/a><p id=\"caption-attachment-13002\" class=\"wp-caption-text\">Chemical structure of a T3 molecule.<\/p><\/div>\n<p>Grave&#8217;s disease results from autoimmune attack on the thyroid gland,<a href=\"#footnote_6_457\" id=\"identifier_6_457\" class=\"footnote-link footnote-identifier-link\" title=\"Ch&rsquo;ng CL, Biswas M, Jones MK, Kingham JG. Prospective screening for celiac disease in patients with Grave&rsquo;s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies. Clinical Endocrinology. Mar. 2005; 62:303-6.\">6<\/a>causing\u00a0diffuse nontender goiter, elevated thyroxine hormone levels (T4, T3), suppressed thyroid stimulating hormone (TSH), and presence of thyroid receptor antibodies in the blood.<\/li>\n<\/ul>\n<h2>Does Grave&#8217;s Disease Respond To Gluten-Free Diet?<\/h2>\n<p>Yes. Gluten free diet treatment of thyroid and celiac disease is successful.<\/p>\n<h2>6 Steps To Improve\u00a0Grave&#8217;s Disease\u00a0In Celiac Disease and\/or Gluten Sensitivity:<\/h2>\n<ul class=\"cp_check green\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>1<\/strong><\/span><\/span><strong><span style=\"color: #800000\">Remove the Trigger. Maintain a Strict, Nutritious Gluten Free Diet:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<b>Treatment<\/b>. This condition responds to the complete elimination of gluten, which is the required treatment that improves both Grave&#8217;s disease\u00a0and gut health.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Gut health is the foundation to restore ALL health. Restored health will enable you to maintain a strict gluten free diet, just as other life tasks will be easier.<\/li>\n<li>A strict gluten free diet means removing 100% of wheat, barley, rye and oats from the diet.<\/li>\n<li>Cutting out bread and other obvious sources of gluten is not good enough for recovery. Even 1\/8th teaspoon of flour or bread crumb is enough to sustain the inflammation that is damaging your small intestine, causing increased permeability (leaky gut) and allowing undigested gluten to enter your body where it can damage structures and function, and instigate immune inflammatory responses.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Correct Your Individual Nutritional Needs.<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eat foods that can replenish missing nutrients. Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<li>Take nutritional supplements as needed.\u00a0Find them under\u00a0NUTRIENT DEFICIENCIES.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Recovery<\/strong>. You should begin to feel better within a week and notice more energy as inflammation subsides and the \u00a0absorbing cells that make up the surface lining of your small intestine are better able to function.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Intestinal lining cells are replaced every 5 days. The healing process is like sunburn where the damaged surface layer of skin sloughs off and is replaced with new normal cells.<\/li>\n<li>Leaky gut normally resolves in two month after starting a gluten free diet and brings about a big improvement in health. Improvement in intestinal permeability precedes morphometric recovery (cell appearance and structure) of the small intestine in celiac disease.<a href=\"#footnote_7_457\" id=\"identifier_7_457\" class=\"footnote-link footnote-identifier-link\" title=\"Cummins AG, Thompson FM, Butler RN, et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease.&nbsp;Clinical Science. Apr 2001;100(4):379-86.\">7<\/a><\/li>\n<li>The intestinal lining may take up to a year to heal.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><span class=\"dropcap\"><strong>2<\/strong><\/span><\/span><strong><span style=\"color: #800000\">\u00a0Reduce Inflammation. Foods to Eat and Foods Not to Eat:<\/span><\/strong><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\">Because gluten is inflammatory, eliminate OTHER inflammatory foods from your diet to reduce an additive effect to gluten. At the same time, try to eat foods that reduce inflammation (anti-inflammatory).<\/p>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Major Inflammatory Food Types That Reduce Healing<\/strong>:<\/p>\n<ul class=\"cp_bullet red\" style=\"text-align: justify\">\n<li><strong>Damaging Foods<\/strong>. In susceptible persons, includes corn, dairy (cow), and soy. Lactose, the sugar in any animal milk disrupts intestinal permeability causing leaky gut.<a href=\"#footnote_8_457\" id=\"identifier_8_457\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">8<\/a><\/li>\n<li><strong>Allergenic Foods<\/strong>. Includes foods that trigger the immune sytem to produce IgE antibodies. Allergy testing is the usual way to discover these offending foods.<\/li>\n<li><strong>Shelf Stable Processed Foods.\u00a0<\/strong>Includes any that contain additives and preservatives. Look for them on the nutrition label of the box or package. Additives and preservatives also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_8_457\" id=\"identifier_9_457\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">8<\/a><\/li>\n<li><strong>Fats.<\/strong>\u00a0Limit deep fried foods, trans-fats, saturated fats (animal fat\/butter), and EXCESSIVE omega-6 fatty acid oils like corn oil. Rancid fats, sodium caprate (a medium chain fat), and sucrose monester fatty acid (a food grade surfactant) induce significant disruption of the intestinal barrier that causes leaky gut.<a href=\"#footnote_8_457\" id=\"identifier_10_457\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">8<\/a>.<\/li>\n<li><strong>Excessive Refined White Flours\u00a0<\/strong>(bran layer removed)<strong>.\u00a0<\/strong>Includes\u00a0products made from them such as cookies, bread, cakes, pies.\u00a0Bran contains the vitamins and minerals that metabolize grains and slows the otherwise rapid entry of sugar from their digestion into the bloodstream.\u00a0Also disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_8_457\" id=\"identifier_11_457\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">8<\/a><\/li>\n<li><strong>Refined Sugars.\u00a0<\/strong>\u00a0Includes white sugar, corn fructose and high fructose corn syrup.<\/li>\n<li><strong>Certain Spices<\/strong>. Includes paprika and cayenne pepper which disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_8_457\" id=\"identifier_12_457\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">8<\/a><\/li>\n<li><strong>Alcohol and Caffeine<\/strong>. Disrupt intestinal permeability causing leaky gut.<a href=\"#footnote_8_457\" id=\"identifier_13_457\" class=\"footnote-link footnote-identifier-link\" title=\"Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.&nbsp;Journal of Gastroenterology and Hepatology. 2003;18:479-91.\">8<\/a>\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Here Are Important Anti-Inflammatory Food Types to Promote Health<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li><strong>Fruits<\/strong>.\u00a0Contain ample amounts of vitamins, minerals and phytochemicals which are\u00a0naturally occuring components in plants that detoxify toxins, carcinogens (reducing the risk by 50%) and mutagens.<\/li>\n<li><strong>Non-Starchy Vegetables.<\/strong>\u00a0Support intestinal integrity and provide ample amounts of vitamins, minerals and phytochemicals. Includes green leafy vegetables such as lettuce and kale, also onion, broccoli, garlic, and others.<\/li>\n<li><strong>High Quality Complex Carbohydrates<\/strong>. Provide vitamins, minerals, and fiber while boosting serotonin levels to help you relax and feel calm. Includes whole grains, legumes, and root vegetables such as carrots, parsnips, sweet potatoes, turnips, red beets, and others.<\/li>\n<li><strong>Antioxidants<\/strong>. Protect the body from inflammatory oxidant molecules that continually occur and\u00a0help us handle stress and reduce irritability. Includes vitamin C-containing foods such as lemon, grapefruit, apricot, Brussels sprouts and strawberries, and others. Also, includes vitamin E-containing foods such as\u00a0nuts, seeds, avocado, olive oil, and others. Cocoa is good, too.<\/li>\n<li><strong>Omega-3 Fatty Acids<\/strong>. Balance opposing omega-6 fatty acids and bad fats. Fish sources includes tuna, salmon, cod, and others. Plants sources include flax, chia seeds, canola oil, and others.<\/li>\n<li><strong>Probiotics.\u00a0<\/strong>Supply normal microbes needed for colon health and health of the body such as these fermented foods: yogurt, kefir, and unpasteurized apple cider vinegar.<\/li>\n<li><strong>Prebiotics\/ High Fiber Foods<\/strong>. \u00a0Food with fiber keeps our population of colonic microbes healthy.<\/li>\n<li><strong>Protective Herbs and Spices<\/strong>. \u00a0See below #6 below for examples.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">3<\/span>\u00a0Information Sheet You Can Take to Your Doctor or Other Health Professional:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\">Click here.<\/p>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><span style=\"color: #800000\"><strong><em><span class=\"dropcap\">4<\/span>\u00a0Manage Your Medications\u00a0Safely<\/em>:<\/strong><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">The anti-thyroid drugs commonly used, Methimazol and propylthiouracyl, that inhibit production of thyroid hormone also interact with a variety of other medication. \u00a0Ask your doctor or pharmacist about this possible adverse effect if you are taking any of the drugs listed below.\u00a0<strong>Do not stop prescribed medications without supervision.<\/strong><\/p>\n<p style=\"text-align: justify\">This is not a complete listing.<\/p>\n<ul class=\"cp_bullet blue\" style=\"text-align: justify\">\n<li>Aminophylline.<\/li>\n<li>Oxtriphylline.<\/li>\n<li>Theophylline (hyperthyroid patients have exhibited increased metabolic clearance of aminophylline and theophylline, which returned to normal as the patients became euthyroid; decreased dose of aminophylline, oxtriphylline, or theophylline may be necessary as patients become euthyroid.<\/li>\n<li>Amiodarone.<\/li>\n<li>Iodinated glycerol.<\/li>\n<li>Iodine.<\/li>\n<li>Potassium iodide (iodide or iodine excess may decrease response to antithyroid agents, requiring an increase in dosage or longer duration of therapy with antithyroid agents; amiodarone contains 37% iodine by weight, and therefore its use significantly increases iodine intake; iodine deficiency may increase response to antithyroid agents, requiring a decrease in dosage or shorter duration of therapy with antithyroid agents.<\/li>\n<li>Anticoagulants, coumarin- or indandione-derivative (as thyroid and metabolic status of patient decreases toward normal, response to oral anticoagulants may decrease; however, if thioamide-induced hypoprothrombinemia occurs, anticoagulant effect may be enhanced; adjustment of oral anticoagulant dosage on the basis of prothrombin time is recommended.<\/li>\n<li>Beta-adrenergic blocking agents (hyperthyroidism causes an increased clearance of beta blockers with a high extraction ratio; dose reduction may be necessary when patient becomes euthyroid. )<\/li>\n<li>Digitalis glycosides (serum concentrations of digoxin and digitoxin have been reported to increase as the thyroid and metabolic status of patients taking antithyroid agents decreased; reduction in dosage of any digitalis glycoside may be necessary as patients become euthyroid)<\/li>\n<li>Sodium iodide I (antithyroid agents may decrease thyroidal uptake of I; a rebound increase in uptake may occur up to 5 days after sudden withdrawal of the antithyroid agent).<a href=\"#footnote_9_457\" id=\"identifier_14_457\" class=\"footnote-link footnote-identifier-link\" title=\"www.drugs.com\/mmx\/methimazole.html\">9<\/a><\/li>\n<\/ul>\n<p style=\"text-align: justify\">\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><em><span style=\"color: #800000\"><strong><span class=\"dropcap\">5<\/span>Nutritional Supplements To Help Correct Deficiencies:<\/strong><\/span><\/em><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t\n<p style=\"text-align: justify\">The type and quantity of nutritional supplements that may be needed depend on which nutrients are deficient.<\/p>\n<ul class=\"cp_bullet orange\" style=\"text-align: justify\">\n<li>Multivitamin\/mineral combination that provides 100% once a day is useful to improve overall nutrient levels. This is a safe dose, but always check with your doctor to avoid interactions with medications.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Storage Note<\/strong>:\u00a0<em>Store container tightly sealed, away from heat, moisture and direct light to avoid loss of potency. That is, in a safe kitchen cabinet &#8211; not in the bathroom or on the kitchen table<\/em>.\n\t\t\t<\/div><\/div>\n<ul class=\"cp_check green\" style=\"text-align: justify\">\n<li><span style=\"color: #800000\"><em><strong><span class=\"dropcap\">6<\/span>Manage Natural Remedies:\u00a0<\/strong><\/em><\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Hydration<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Eight glasses of water are recommended per day unless there is a contraindication such as kidney or heart disease. The Institute of Medicine recommends approximately 2.7 liters (91 ounces) of total water, from all beverages and foods, each day for women and 3.7 liters (125 ounces) daily of total water for men.<\/li>\n<li>If you are thirsty, drink water. Add fresh, squeezed lemon to water. Lemon is anti-inflammatory, alkalizing and provides vitamin C.<\/li>\n<li>Hydration Test: Urine should be pale yellow. Fingertips should be plump, without pruning but this may not be reliable when fingers are swollen with edema. Lips should be plump, without puckering. The feeling of thirst can be unreliable.<\/li>\n<li>What is wrong with soda, coffee, tea, and alcohol? These drinks are dehydrating, increase acid, and deplete nutrients.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Carminatives.\u00a0<\/strong>The following \u00a0anti-inflammatory\u00a0plant sources called carminitives help heal the digestive tract. They also tone the digestive muscles which improves peristalsis, thus aiding in the expulsion of gas from the stomach and intestine to relieve digestive colic and gastric discomfort.<\/p>\n<p style=\"text-align: justify\"><strong>Carminative Food Remedies<\/strong>:<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Raspberry.<\/li>\n<li>Carrot is also a cleansing digestive tonic.<\/li>\n<li>Grape is also bile stimulating and a cleansing remedy for sluggish digestion and laxative.<\/li>\n<li>Redbeets also stimulate and improve digestion and are easily digested.<\/li>\n<li>Cabbage also stimulates and improves digestion and is also a liver decongestant.<\/li>\n<li>Lettuce also stimulates and improves digestion and is also an alterative, meaning it improves the function of organs involved with the digestion and excretion of waste products to bring about a gradual change.<\/li>\n<li>Potatoes are antispasmodic (due to atropine like properties) and a liver remedy.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Herb Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Sage is also a digestive, astringent, bile stimulant and energy tonic that heals the mucosa. \u00a0Drink as tea or use in cooking.<\/li>\n<li>Chamomile, lemon balm, and fennel, (as a tea) also help relieve nervous tension.<\/li>\n<li>Parsley also relieves indigestion.<\/li>\n<li>Rosemary as a tea and in cooking also is a nervous system tonic for stress and fatigue, bile stimulant, and can relieve headaches and indigestion.<\/li>\n<li>Thyme is also soothing remedy useful for stimulating digestion of rich, fatty foods.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Carminative Spice Remedies:<\/strong><\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Cloves are also antispasmodic.<\/li>\n<li>Nutmeg is also useful for indigestion.<\/li>\n<li>Ginger.\n\t\t\t<\/div><\/div><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><div class=\"box shadow\"><div class=\"box-inner-block\"><i class=\"tieicon-boxicon\"><\/i>\n\t\t\t<strong>Exercise Helps<\/strong>:<\/p>\n<p style=\"text-align: justify\">Exercise improves circulation and rids the body of toxins.<\/p>\n<ul class=\"cp_bullet green\" style=\"text-align: justify\">\n<li>Walking is aerobic exercise that reconditions the whole body to improve stamina.\u00a0Read more about<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">\u00a0Exercise and Fitness<\/a>.<\/li>\n<li>Weight training builds muscle.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<li>Stretching improves flexibilty.\u00a0Read more about\u00a0<a href=\"https:\/\/glutenfreeworks.com\/health\/2014\/07\/08\/fitness-guide\/\">Exercise and Fitness<\/a>.<\/li>\n<\/ul>\n<p style=\"text-align: justify\"><strong>Note<\/strong>: Exercise is important, but the amount and type of exercise undertaken depends on your health. Your first priority is to heal. \n\t\t\t<\/div><\/div>\n<h2 style=\"text-align: justify\">What Do Medical Research Studies Tell About Grave&#8217;s Disease In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n<h4><span style=\"color: #000000\"><strong>RESEARCH STUDY SUMMARIES<\/strong><\/span><\/h4>\n<p style=\"text-align: justify\"><strong>&#8220;Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity<\/strong>.&#8221; This cross-sectional study investigating the prevalence of autoimmune co-morbidity in patients with autoimmune thyroid disease \u00a0with and without thyroid-associated orbitopathy (TAO) found that in patients with TAO, celiac disease is the most prevalent co-morbid autoimmune condition and rates are increased compared to Grave\u2019s disease patients without TAO.<\/p>\n<p style=\"text-align: justify\">Of 1,310 patients with autoimmune thyroid disease \u00a0(777 or 59% with Graves&#8217; disease and 533 or 41% with Hashimoto&#8217;s thyroiditis) followed at a specialized joint thyroid-eye outpatient clinic, 176 (13.4%) had an adult type of the autoimmune polyglandular syndrome, 129 (9.8%) type 1 diabetes, 111 (8.5%) celiac disease, 60 (4.6%) type A autoimmune gastritis, 57 (4.4%) vitiligo and 25 (1.9%) had Addison&#8217;s disease. Celiac disease and autoimmune gastritis were positively associated with Grave\u2019s disease, whereas type 1 diabetes, Addison&#8217;s disease, autoimmune primary hypogonadism, alopecia areata, rheumatoid arthritis, and Sj\u00f6gren&#8217;s syndrome were &#8220;protective&#8221; for Grave\u2019s disease and thus linked to Hashimoto&#8217;s thyroiditis. Of 610 (46.6%) autoimmune thyroid disease\u00a0patients with TAO, 584 (95.7%) and 26 (4.3%) had Grave\u2019s disease and Hashimoto&#8217;s thyroiditis, respectively.<\/p>\n<p style=\"text-align: justify\">TAO was most prevalent in Grave\u2019s disease patients with celiac disease (94%).<a href=\"#footnote_10_457\" id=\"identifier_15_457\" class=\"footnote-link footnote-identifier-link\" title=\"Ponto K, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T, Pitz S, Pfeiffer N, Kahaly G. Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. Clin Exp Immunol. 2014 Jun 5. doi: 10.1111\/cei.12395.\">10<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cProspective screening for celiac disease in patients with Grave\u2019s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies.\u201d<\/strong> This study investigating the prevalence of celiac disease in patients with Grave&#8217;s disease and evaluating the role of screening for celiac disease prospectively demonstrated that routine screening for celiac disease should be considered. Screening of 111 consecutive patients with Grave&#8217;s hyperthyroidsm revealed anti-gliadin antibodies in 14%, anti-tissue transglutaminase antibodies in 2% and IgA deficiency in 3%.<a href=\"#footnote_11_457\" id=\"identifier_16_457\" class=\"footnote-link footnote-identifier-link\" title=\"Ch&rsquo;ng CL, Biswas M, Jones MK, Kingham JG. Prospective screening for celiac disease in patients with Grave&rsquo;s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies. Clinical Endocrinology. Mar. 2005; 62:303-6.\">11<\/a><\/p>\n<h4 style=\"text-align: justify\"><span style=\"color: #000000\"><strong>CASE REPORT SUMMARIES<\/strong><\/span><\/h4>\n<p style=\"text-align: justify\"><strong>&#8220;Graves&#8217; disease and celiac disease: screening and treatment dilemmas.&#8221;<\/strong> This case report describes the course of a 37-year-old woman with Graves&#8217; disease who presented with thyrotoxicosis that was not responsive to medical management. The screening for celiac autoimmunity was positive. After initiation of a gluten-free diet the patient&#8217;s thyrotoxicosis responded to medical management. She was given radioiodine therapy and is currently hypothyroid on a stable dose of thyroxine.<a href=\"#footnote_12_457\" id=\"identifier_17_457\" class=\"footnote-link footnote-identifier-link\" title=\"Joshi AS1, Varthakavi PK, Bhagwat NM, Thiruvengadam NR. Graves&rsquo; disease and coeliac disease: screening and treatment dilemmas. BMJ Case Rep. 2014 Oct 23;2014. pii: bcr2013201386. doi: 10.1136\/bcr-2013-201386.\">12<\/a><\/p>\n<p style=\"text-align: justify\"><strong>\u201cCeliac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves Disease.\u201d<\/strong> This case report describes celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9-month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves disease.<a href=\"#footnote_13_457\" id=\"identifier_18_457\" class=\"footnote-link footnote-identifier-link\" title=\"Hwang IK, Kim SH, Lee U, Chin SO, Rhee SY, Oh S, Woo JT, Kim SW, Kim YS, Chon S. Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves Disease. Endocrinol Metab (Seoul). 2014 Jul 18.\">13<\/a><\/p>\n<p style=\"text-align: justify\"><strong>&#8220;Treatment-refractory hypothyroidism.&#8221;<\/strong> This case report describes diagnosing celiac disease in a 49-year-old man who was referred to an endocrine clinic because of rising thyroid-stimulating hormone (TSH) levels despite increasing doses of levothyroxine. The patient had a history of Grave\u2019s disease, which had been successfully treated with radioiodine ablation 15 years earlier. Over the past several years, his serum TSH levels had risen to 31.5 (normal 0.4\u20134.5) mU\/L, and the dose of levothyroxine he was prescribed had been increased to 225 \u03bcg per day, or 2.7 (usual recommended dose 1.6) \u03bcg\/kg daily. The patient\u2019s weight was 82 kg, and he did not report any change to his weight. The patient reported feeling well, and his physical exam was unremarkable. His level of free thyroxine was 15.8 (normal 10\u201325) pmol\/L. The patient reported taking his antihypertensive medication (diltiazem) regularly as prescribed, and he was not taking any over-the-counter medications or herbal supplements.<\/p>\n<p style=\"text-align: justify\">The patient\u2019s adherence to the drugs he had been prescribed was confirmed, and to exclude impaired bioavailability of the medication,a medically supervised test for the absorption of levothyroxine was performed. The results of the test showed that only 30% of the medication administered was absorbed. Tests were performed to rule out levothyroxine maldigestion related to gastric hypochlorhydria.\u00a0Laboratory investigations included a biochemistry panel and tests for serum levels of parathyroid hormone, 25-hydroxyvitamin D, ferritin, vitamin B12 and gastrin, all of which showed normal results. A blood test to determine the presence of Helicobacter pylori infection was negative, and the patient\u2019s parietal cell antibody titers were normal. Given these results, it was unlikely that the patient\u2019s treatment-refractory hypothyroidism was related to hypochlorhydria.<\/p>\n<p style=\"text-align: justify\">In the investigation of intestinal malabsorption, the screening serum test for gluten enteropathy was abnormal; the level of immunoglobulin A antibodies against transglutaminase was 75.4 (negative &lt; 9.0, borderline 9\u201316, positive &gt; 16.0) units\/mL. A subsequent endoscopic biopsy of the patient\u2019s bowel was consistent with a diagnosis of celiac disease. The patient was directed to follow a low-gluten diet. The patient\u2019s histological abnormalities resolved, and his serum level of TSH normalized with his usual dose of thyroxine (225 \u03bcg daily).<br \/>\nBecause of the patient\u2019s previous Grave\u2019s disease, an autoimmune polyglandular syndrome was investigated. Subsequent tests showed elevated antiadrenal and 21-hydroxylase antibodies, suggesting autoimmune adrenalitis. A short intravenous adrenocorticotropic hormone (ACTH) stimulation test was consistent with diminished adrenal cortisol reserve.<a href=\"#footnote_14_457\" id=\"identifier_19_457\" class=\"footnote-link footnote-identifier-link\" title=\"Ramadhan A, Tamilia M. Treatment-refractory hypothyroidism. CMAJ. 2012 Feb 7;184(2):205-9. doi: 10.1503\/cmaj.110994.\">14<\/a><\/p>\n<ol class=\"footnotes\"><li id=\"footnote_1_457\" class=\"footnote\">Taber&#8217;s Cyclopedic Medical Dictionary. 19th ed. F.A. Davis Company. Philadelphia, PA.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_2_457\" class=\"footnote\">Ch\u2019ng CL, Biswas M, Jones MK, Kingham JG. Prospective screening for celiac disease in patients with Grave\u2019s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies.\u00a0<em>Clinical Endocrinology<\/em>. Mar. 2005; 62:303-6.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_2_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_3_457\" class=\"footnote\">La Villa G, Pantaleo P, Tarquini R, Cirami L, Perfetto F, Mancuso F, Laffi G. Multiple immune disorders in unrecognized celiac disease: a case report.<em> World J Gastroenterol<\/em>. 2003;9(6):1377-1380.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_3_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_4_457\" class=\"footnote\">Ponto K, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T, Pitz S, Pfeiffer N, Kahaly G. Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. <em>Clin Exp Immunol.<\/em> 2014 Jun 5. doi: 10.1111\/cei.12395.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_4_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_5_457\" class=\"footnote\">Ch\u2019ng CL, Biswas M, Jones MK, Kingham JG. Prospective screening for celiac disease in patients with Grave\u2019s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies. <em>Clinical Endocrinology<\/em>. Mar. 2005; 62:303-6.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_5_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_6_457\" class=\"footnote\">Ch\u2019ng CL, Biswas M, Jones MK, Kingham JG. Prospective screening for celiac disease in patients with Grave\u2019s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies. Clinical Endocrinology. Mar. 2005; 62:303-6.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_6_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_7_457\" class=\"footnote\">Cummins AG, Thompson FM, Butler RN, et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease.\u00a0<em>Clinical Science<\/em>. Apr 2001;100(4):379-86.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_7_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_8_457\" class=\"footnote\">Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease.\u00a0<em>Journal of Gastroenterology and Hepatology<\/em>. 2003;18:479-91.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_8_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_9_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_10_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_11_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_12_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_13_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_9_457\" class=\"footnote\">www.drugs.com\/mmx\/methimazole.html<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_14_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_10_457\" class=\"footnote\">Ponto K, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T, Pitz S, Pfeiffer N, Kahaly G. Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. <em>Clin Exp Immunol<\/em>. 2014 Jun 5. doi: 10.1111\/cei.12395.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_15_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_11_457\" class=\"footnote\">Ch\u2019ng CL, Biswas M, Jones MK, Kingham JG. Prospective screening for celiac disease in patients with Grave\u2019s hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies. <em>Clinical Endocrinolog<\/em>y. Mar. 2005; 62:303-6.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_16_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_12_457\" class=\"footnote\">Joshi AS1, Varthakavi PK, Bhagwat NM, Thiruvengadam NR. Graves&#8217; disease and coeliac disease: screening and treatment dilemmas. <em>BMJ Case Rep.<\/em> 2014 Oct 23;2014. pii: bcr2013201386. doi: 10.1136\/bcr-2013-201386.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_17_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_13_457\" class=\"footnote\">Hwang IK, Kim SH, Lee U, Chin SO, Rhee SY, Oh S, Woo JT, Kim SW, Kim YS, Chon S. Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves Disease. <em>Endocrinol Metab (Seoul)<\/em>. 2014 Jul 18.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_18_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_14_457\" class=\"footnote\">Ramadhan A, Tamilia M. Treatment-refractory hypothyroidism. <em>CMAJ<\/em>. 2012 Feb 7;184(2):205-9. doi: 10.1503\/cmaj.110994.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_19_457\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>What Is Grave&#8217;s Disease (Hyperthyroidism)? Grave&#8217;s disease, or hyperthyroidism, is an autoimmune thyroid disease characterized by diffuse nontender goiter, elevated thyroxine hormone levels (T4, T3), suppressed thyroid stimulating hormone (TSH), and presence of thyroid receptor antibodies in the blood. The autoantibodies involved are anti-thyroid peroxidase and anti-thyroglobulin antibodies. They bind to the thyroid stimulating hormone &#8230;<\/p>\n","protected":false},"author":29,"featured_media":3348,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4,130,779,175,66,172],"tags":[386,101,1162,470,1156,776,314,1164,1157,1160,1163,455,1155,1161,1159,1158,1896,1945,1153,1154,434],"class_list":["post-457","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-conditions-2","category-adipose","category-associated-disorder","category-body-composition","category-glandular-2","category-thyroid","tag-anxiety","tag-associated-disorders","tag-brisk-tendon-reflexes","tag-depression","tag-drooping-eyelids","tag-health-conditions","tag-hyperthyroidism-graves-disease","tag-increased-blood-pressure","tag-myxedema","tag-nervousness","tag-oligomenorrhea","tag-palpitations","tag-proptosis","tag-proximal-muscle-weakness","tag-rapid-pulse","tag-staring","tag-glandular-2","tag-thyroid","tag-thyroxine-hormone","tag-tsh","tag-weight-loss"],"_links":{"self":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/comments?post=457"}],"version-history":[{"count":26,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/457\/revisions"}],"predecessor-version":[{"id":18888,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/457\/revisions\/18888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media\/3348"}],"wp:attachment":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media?parent=457"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/categories?post=457"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/tags?post=457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}