{"id":360,"date":"2016-08-25T17:30:29","date_gmt":"2016-08-25T21:30:29","guid":{"rendered":"http:\/\/www.mynutriguide.com\/?p=360"},"modified":"2020-07-11T10:38:25","modified_gmt":"2020-07-11T14:38:25","slug":"collagenous-colitis-2","status":"publish","type":"post","link":"https:\/\/glutenfreeworks.com\/health\/collagenous-colitis-2\/","title":{"rendered":"Colitis,\u00a0Collagenous"},"content":{"rendered":"
\"Collagenous<\/a>

Microscopic Image Showing a Pink Collagen Band in Collagenous Colitis.<\/p><\/div>\n

What Is Collagenous Colitis?<\/h2>\n

C<\/span>ollagenous colitis is a disease of the large intestine (colon) that is characterized by microscopic inflammation of the surface mucosal lining\u00a0and an abnormally thickened collagen band of tissue that develops wthin the lining of the colon.<\/p>\n

The thicker than normal layer of collagen of at least 10 \u00b5m (reference value: 2\u20137 \u00b5m) can vary in different locations. Inflammation occurs with increased numbers of lymphocytes (white blood cells) and plasma cells and epithelial (surface cell) damage. These changes can only be seen under microscopic examination of multiple biopsied tissue samples taken during a colonoscopy procedure.<\/p>\n

Q:<\/strong> What is collagen?<\/span><\/p>\n

A:<\/strong>\u00a0<\/span>Collagen is a strong, fibrous protein found in connective tissue of the colon and many other tissues such as tendons.\u00a0The normal basement membrane in the bowel consists mainly of collagen type IV, laminin, and fibronectin. The increased collagen band observed in collagenous colitis consists basically of collagen type I and III, which are the subtypes produced by repair functions, indicating a reactive origin to some irritant or drug.1<\/a><\/p>\n

The biopsies should preferably be taken from the ascending colon, since the pathological hallmarks may be absent in the descending colon, and in the normally occurring thicker collagen layer in the rectosigmoid region.1<\/a>\u00a0Inflammation of the ileum (last segment of the small intestine next to colon) is common.2<\/a><\/p>\n

Endoscopy and radiological (x-ray) examinations are usually normal.3<\/a><\/p>\n

Autoimmune disorders are frequently seen in adult patients with collagenous colitis.4<\/a> In the study below by Koskela et al. concomittent autoimmune diseases were present in 53% of patients with collagenous colitis.5<\/a><\/p>\n

Importantly, the finding of collagenous colitis in patients with autoimmune diseases may reflect the treatment with NSAIDs (non-steroidal anti-inflammatory drugs), such as Ibuprofin and aspirin, PPIs (proton pump inhibitors), and other drugs. However, if secondary forms of collagenous colitis are not taken into consideration, underlying, treatable diseases may be overlooked, while only the gastrointestinal symptoms are treated symptomatically or with budesonide (a steroid).6<\/a><\/p>\n

Treatment with budesonide steroid is efficacious irrespective of bile acid malabsorption.7<\/a><\/p>\n

Budesonide at a mean dose of 4.5\u2005mg\/day maintained clinical remission for at least 1\u2005year in the majority of patients with collagenous colitis and preserved health-related quality of life without safety concerns. Treatment extension with low-dose budesonide beyond 1\u2005year may be beneficial given the high relapse rate after budesonide discontinuation.8<\/a><\/p>\n

See below for nutritional deficiency problems caused by steroid usage and steps to be taken for correction.<\/p>\n

What Is Collagenous Colitis In Celiac Disease and\/or Gluten Sensitivity?<\/h2>\n

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