{"id":17661,"date":"2016-08-29T15:52:42","date_gmt":"2016-08-29T19:52:42","guid":{"rendered":"http:\/\/glutenfreeworks.com\/health\/?p=17661"},"modified":"2020-07-11T10:38:23","modified_gmt":"2020-07-11T14:38:23","slug":"celiac-disease-genetic-susceptibility-definition","status":"publish","type":"post","link":"https:\/\/glutenfreeworks.com\/health\/celiac-disease-genetic-susceptibility-definition\/","title":{"rendered":"Celiac Disease, Genetic Susceptibility: definition"},"content":{"rendered":"<p style=\"text-align: justify\">An inherited disease in which much of the genetic susceptibility maps to the HLA region on chromosome 6, as approximately 95% of celiac disease patients carry an almost identical HLA DQ2 heterodimer (DQA1*0501 DQB1*0201).<\/p>\n<p style=\"text-align: justify\">In most individuals who are negative for HLA DQ2, this disease is associated with the class II alleles DQA1*0301 and DQB1*0302, which encode a DQ8 molecule linked to DR4 haplotypes.<a href=\"#footnote_1_17661\" id=\"identifier_1_17661\" class=\"footnote-link footnote-identifier-link\" title=\"Mazzarella G. Effector and suppressor T cells in celiac disease. World J Gastroenterol. 2015 Jun 28;21(24):7349-56. doi: 10.3748\/wjg.v21.i24.7349.\">1<\/a><\/p>\n<ol class=\"footnotes\"><li id=\"footnote_1_17661\" class=\"footnote\">Mazzarella G. Effector and suppressor T cells in celiac disease. <em>World J Gastroenterol.<\/em> 2015 Jun 28;21(24):7349-56. doi: 10.3748\/wjg.v21.i24.7349.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_17661\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>An inherited disease in which much of the genetic susceptibility maps to the HLA region on chromosome 6, as approximately 95% of celiac disease patients carry an almost identical HLA DQ2 heterodimer (DQA1*0501 DQB1*0201). In most individuals who are negative for HLA DQ2, this disease is associated with the class II alleles DQA1*0301 and DQB1*0302, &#8230;<\/p>\n","protected":false},"author":29,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[774],"tags":[2095],"class_list":["post-17661","post","type-post","status-publish","format-standard","hentry","category-dictionary","tag-glossary"],"_links":{"self":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/17661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/comments?post=17661"}],"version-history":[{"count":5,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/17661\/revisions"}],"predecessor-version":[{"id":17668,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/posts\/17661\/revisions\/17668"}],"wp:attachment":[{"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/media?parent=17661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/categories?post=17661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/glutenfreeworks.com\/health\/wp-json\/wp\/v2\/tags?post=17661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}