What Is Increased Pulmonary Permeability?
Increased pulmonary permeability is a mucosal defect in the lung characterized by alteration of the normally tight epithelial blood-air barrier in the lung apparently caused by inflammation.
Q: What is the blood-air barrier in the lung?
A: This blood-air barrier in the lung consists of the alveolar epithelium (surface cells of the alveoli), the underlying capillary endothelium (surface cells of the capillaries), their basement membranes and the interstitial space between the cell layers.
Alveoli are also called “air sacs.” The exchange of oxygen breathed into air sacs from air on inspiration and carbon dioxide breathed out from capillary blood on expiration occurs between air sacs and capillaries.
The capillary endothelium prevents proteins in blood from leaking (permeating) into the air sacs while allowing water and small molecules to pass. This is why breath has moisture in it.
Little is known about the interactions between the alveolar and the blood compartment.1
What Is Increased Pulmonary Permeability In Celiac Disease and/or Gluten Sensitivity?
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Neuhaus W, Samwer F, Kunzmann S, Muellenbach RM, Wirth M, Speer CP, Roewer N, Förster CY. Lung endothelial cells strengthen, but brain endothelial cells weaken barrier properties of a human alveolar epithelium cell culture model. Differentiation. 2012 Nov;84(4):294-304. doi: 10.1016/j.diff.2012.08.006. Epub 2012 Sep 27. ↩