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Brain Blood Flow Abnormalities 

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blood perfusion gluten celiac diseaseWhat Are Brain Blood Flow Abnormalities?

Brain blood flow abnormalities, or cerebral perfusion abnormalities, such as spasm of blood vessels causing inadequate blood flow to the brain, are characterized by impaired brain function and thinking.

Q: What is cerebral perfusion?

A: Cerebral perfusion is the flow of blood in the brain. Blood supply to the brain comes from 4 major vessels: 2 carotid arteries and 2 vertebral arteries.

Cerebral perfusion abnormalities can be diagnosed using perfusion computed tomography (CT). CT scan is a technique that allows rapid qualitative and quantitative evaluation of cerebral perfusion by generating maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). The technique is based on the central volume principle (CBF = CBV/MTT) and requires the use of commercially available software employing complex deconvolution algorithms to produce the perfusion maps.

Perfusion CT has been found to be useful for noninvasive diagnosis of cerebral ischemia (diminished blood flow) and infarction (no blood flow) and for evaluation of vasospasm (intermittent blood flow through vessels).1

What Are Brain Blood Flow Abnormalities In Celiac Disease and/or Gluten Sensitivity?


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  1. Hoeffner E, Case I, Jain R, et al. Cerebral Perfusion CT: Technique and Clinical Applications. June 2004 Radiology, 231, 632-644. []