In the first double blind randomized placebo-controlled study of gluten and symptoms in people without celiac disease, researchers from Australia have confirmed that gluten is a trigger of digestive symptoms and fatigue. They concede that “non-celiac gluten intolerance” may exist.
The researchers challenged and re-challenged people with IBS in whom celiac disease had been excluded whose symptoms were controlled on a gluten-free diet. These individuals were randomized to gluten-free diet with daily supplements of muffins and bread with a standard amount of gluten added or not added. Both the patients and the (more…)
Adults that have been diagnosed with Celiac Disease are being sought to participate in a study to identify factors associated with the development of Celiac Disease. The goal of the study is to find the genes that may predispose individuals to develop this autoimmune disease. Adults eligible to participate in this study must have been diagnosed with Celiac Disease through a small intestinal biopsy. Spouses may also be eligible to participate.
Participants will be asked to provide a blood sample, complete a questionnaire, and provide medical records regarding their diagnosis. There is no cost to (more…)
In the following medical research study, healthy participants were enrolled to examine the effects of vitamin D on insulin production and use in the body. This research shows that:
1) Vitamin D plays an important role in insulin sensitivity in the body, and deficiency of vitamin D hampers production of insulin hormone by beta cells in the pancreas.
2) People with vitamin D deficiency are at risk for developing type 2 diabetes mellitus. Type 2 diabetes mellitus is characterized by lack of insulin sensitivity in body tissues and inadequate production of insulin hormone in the pancreas. (more…)
In this study, researchers investigating the absorption of copper in untreated patients who had damage to their duodenum found anemia in 3 out of 10 of these patients that was due to copper deficiency. They gave all the study subjects a solution of copper to drink that was equal to a daily dose then tested their blood level. (more…)
Editor’s note: This important study demonstrated that short chain fatty acid (SCFA) levels in stool samples were abnormal in participating children with celiac disease, with and without treatment with gluten-free diet. SCFAs are healthy energy byproducts produced by microflora (beneficial organisms) in the colon during fermentation of undigested carbohydrates arriving from the small intestine. SCFAs nourish the colonocytes, cells that line the colon, to maintain normal function. They also help absorb salts and water from stool.
Editor’s note: Promising research published January 8, 2007 shows that adequate levels of vitamin D in the elderly are important to maintain cognitive function or thinking skills that include use of language, awareness, social skills, math ability, memory, reasoning, judgment, intellect, learning, and imagination. This study is called a retrospective review because the researchers did not actually examine anyone. Instead they reviewed data from records of 32 older adults who had been examined for memory (more…)
Editor’s note: In this case report of infants with severe malabsorption from celiac disease, the treating physicians found copper deficiencies based on blood studies that showed severe low copper levels and white blood cell count. Treatment required copper supplementation in addition to the gluten-free diet. Normally, in the last few months of gestation, an infant stores a large amount of copper in their liver. This storage must last about 6 months because infants must derive their nourishment from copper-poor milk. This case report shows dramatically the terrible effect of malabsorption coupled with a naturally occurring huge demand for copper that could not be satisfied through digestion. (more…)
Editors’ note:This study investigating the value and safety of Candin for clinical use in children demonstrated effectiveness and safety. Candin is a reagent or skin test for sensitivity to Candida albicans, a yeast microorganism that can cause infection. The study recommends using Candin in combination with other reagents in infants with anergy to see if they react to antigens other than Candida albicans. Anergy is described in Taber’s Cyclopedic Medical Dictionary as the impaired or absent ability to react to common antigens administered through skin testing. Antigens are markers on the surface of cells that stimulate production of antibodies. In this study, Candin was tested at the same time as a skin test for tuberculosis (purified protein derivative tuberculosis) for comparison of results. (more…)
According to the National Digestive Diseases Information Clearing House, a study published in the December 2008 issue of the Journal of Insurance Medicine reports that researchers from Columbia University and CIGNA HealthCare found that diagnosis of celiac disease substantially reduces subsequent health care costs.
The research group, led by Peter Green, M.D., a renowned authority in celiac disease from Columbia University, looked at medical records for 10.2 million CIGNA managed care members. (more…)
Scientists who last year identified a new genetic risk factor for coeliac disease, have, following continued research, discovered an additional seven gene regions implicated in causing the condition. The team, lead by David van Heel, Professor of Gastrointestinal Genetics at Barts and The London School of Medicine and Dentistry, have further demonstrated that of the nine coeliac gene regions now know, four of these are also predisposing factors for type 1 diabetes. Their research sheds light not only on the nature of coeliac disease, but on the common origins of both diseases. It is published online today (2 March 2008) in Nature Genetics. (more…)