Research

MEDICAL RESEARCH: “Copper Deficiency in Infants with Active Celiac Disease.”


Editor’s note: In this case report of infants with severe malabsorption from celiac disease, the treating physicians found copper deficiencies based on blood studies that showed severe low copper levels and white blood cell count.  Treatment required copper supplementation in addition to the gluten-free diet.  Normally, in the last few months of gestation, an infant  stores a large amount of copper in their liver.  This storage must last about 6 months because infants must derive their nourishment from copper-poor milk.  This case report shows dramatically the terrible effect of malabsorption coupled with a naturally occurring huge demand for copper that could not be satisfied through digestion. Read More »

Does the severity of celiac disease symptoms correspond with degree of villous atrophy?


Editor’s note: The study below, investigating whether the degree of villous atrophy (intestinal damage) correlates with the symptoms that are presented, found they do not. Therefore, more research is needed to find out why symptoms do not correlate with the degree of intestinal damage.

The pathologic range of villous atrophy seen on small intestinal biopsies ranges from severe (total villous atrophy and subtotal villous atrophy) to milder, partial villous atrophy. Read More »

Don’t be a Statistic. Medical Mistakes are the Third Leading Cause of Death in the United States.


13502036_10154102429271815_7497922383029815833_n[1]A recent Johns Hopkins study found medical mistakes are the third leading cause of death in the United States, killing between 200,000 and 400,000 per year.

The study does not even consider misdiagnoses, or how many people suffer injuries without dying. We frequently see people who are medicated for what doctors think are diseases, but are actually symptoms with underlying causes. This is why we created the Gluten Free Works Health Guide – to improve proper diagnosis and treatment – so you and your doctor could connect the dots between hundreds of symptoms and their causes, causes like nutrient deficiencies that doctors do not recognize.

“Medical mistakes — from surgical disasters to accidental drug overdoses — are the No. 3 cause of death in the U.S., behind cancer and heart disease, two experts argued Wednesday.

They said a careful count of all deaths from preventable medical errors shows between 200,000 and 400,000 people a year die in the U.S. from these mistakes. The only way to get the country to do something about them is to start counting them, Dr. Martin Makary and Michael Daniel of Johns Hopkins University medical school argued.

“We spend a lot of money on cancer and heart disease but we have not even recognized that medical error is the third leading cause of death in the United States,” Makary told NBC News.

“We have not as a country recognized the endemic problem of people dying from the care that they receive rather than the illness or injury for which they seek care.” Read the rest of the story at NBC News. The case report is available at the New England Journal of MedicineRead More »

New Study Finds Link between Celiac Disease and Obesity in Patients


gluten overweight weight gain[Editor’s Note: Originally published October, 11, 2012]

Lately, it seems like more and more celebrities and professional athletes are openly talking about going gluten free. Whether it’s due to a diagnosis of celiac disease or a gluten sensitivity, or simply because they want to get healthy, many of them have noted a weight loss as part of the benefits they’ve been seeing. Then why is it, that so many doctors and specialists will dismiss a diagnosis of celiac disease in a patient simply because the patient is not underweight?

In a recent article by Sonia Kupfer, MD, the belief that people with un-diagnosed celiac disease are all underweight is revealed to  Read More »

Shocking Facts About Celiac Disease


celiac awareness month

Photo credit: Celiac Disease Awareness Month

May is National Celiac Disease Awareness Month, so it seems appropriate to share some medical facts about this autoimmune disease that just might shock you.

These facts come from Dr. Tom O’Bryan who is is a nationally recognized speaker and workshop leader specializing in gluten sensitivity and celiac disease.  Dr. O’Bryan’s specialty is in teaching the many manifestations of gluten sensitivity and celiac disease as they occur inside and outside of the Read More »

Study Finds 1 in 5 Children With Celiac Disease Sustain Intestinal Damage Even on a Gluten-Free Diet


baby-sleepingIn a new medical study, researchers from MassGeneral Hospital for Children (MGHfC) and Boston Children’s Hospital (BCH) were surprised to discover that nearly one in five children with celiac disease sustained persistent intestinal damage, despite strict adherence to a gluten-free diet.1

These findings are consistent with research in adults, which showed that more than 33 percent of adult patients on a gluten-free diet have persistent intestinal damage, despite a reduction of symptoms or the results of blood tests.

Current guidelines for pediatric celiac disease patients recommend a single biopsy at diagnosis and follow-up blood testing to monitor recovery of the intestinal mucosa. It was assumed that intestinal mucosa (lining) healed in children after adopting a strict gluten-free diet and that the blood tests would accurately reflect whether healing was occurring or not. It appears this assumption was Read More »


  1. http://www.news-medical.net/news/20161130/Study-finds-1-in-5-pediatric-celiac-disease-patients-on-gluten-free-diet-sustain-persistent-intestinal-damage.aspx 

Innovate Biopharmaceuticals Completes License For Late-Stage Celiac Disease Asset From Alba Therapeutics

Alba_Logo[1]Alba Therapeutics has been working on a therapy for celiac disease the past 8 years. Alba’s therapy, Larazotide Acetate, is the first to reach phase 3 clinical trials, where it will be given to large groups of people.

When Alba first contacted us about helping to promote their phase 2 clinical trial, we investigated the therapy’s mechanism and were glad to see the drug is not absorbed into the body, but acts in the intestine to stop gluten from being absorbed. Better yet, it worked. We covered Larazote Acetate in our article, Medical Research Study to Test a Potential Celiac Disease Therapy Is Underway and Signing up Participants.

A real therapy for celiac disease is one step closer. Alba just sent us the following press release concerning their deal with Innovate Biopharmaceuticals to produce the therapy.  Read More »

Stanford University Seeks Celiac Disease Study Participants

 

StanfordSeal[1]Jennifer Iscol, of the Celiac Community Foundation of Northern California, just distributed this message regarding a celiac disease study at Stanford University.

“Volunteers are needed for a genetic study on celiac disease at Stanford University. Please consider participating. Community participation is an essential component of Stanford’s celiac disease research. The research benefits all of us and future generations.

http://www.celiaccommunity.org/stanford-celiac-genetic-study/

Announcement from Stanford:

We are conducting a study to understand the genetic basis of celiac disease.  Families with at least one parent and one child with celiac disease are encouraged to enroll together.

The study involves: Read More »

BioLineRX’s BL-7010 Treatment of Celiac Disease and Gluten Sensitivity Presented

biolinerx celiac disease therapy

BioLineRx Therapy BL – 7010 Treats Celiac Disease & Gluten Sensitivity

BioLineRx Ltd, a biopharmaceutical development company, was invited to deliver an oral presentation at the recent 2013 National Education Conference & Gluten-Free Expo, the Celiac Disease Foundation’s annual conference, in Pasadena, California.

Leah Klapper, Ph.D., General Manager, BioLine Innovations Jerusalem, presented BioLineRx’s therapy, BL-7010, for the treatment of celiac, as part of a session entitled Breaking Therapies Beyond the Gluten-Free Diet.

BL-7010 will be presented at Read More »

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